PPP1R16B - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
GOLGA2	golgin A2	Golgi Cisternae Pericentriolar Stack Reorganization Golgi Cisternae Pericentriolar Stack Reorganization COPII-mediated vesicle transport COPI-mediated anterograde transport Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
HAPLN2	hyaluronan and proteoglycan link protein 2
IKZF3	IKAROS family zinc finger 3
KCTD9	potassium channel tetramerization domain containing 9
MAGOH	mago homolog, exon junction complex subunit	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
MISP	mitotic spindle positioning
NEFL	neurofilament light	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
PATZ1	POZ/BTB and AT hook containing zinc finger 1
PHC2	polyhomeotic homolog 2	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
PLEKHN1	pleckstrin homology domain containing N1
PPP1CA	protein phosphatase 1 catalytic subunit alpha	Triglyceride catabolism DARPP-32 events Downregulation of TGF-beta receptor signaling Circadian Clock	2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
PPP1CB	protein phosphatase 1 catalytic subunit beta	Triglyceride catabolism Downregulation of TGF-beta receptor signaling Regulation of PLK1 Activity at G2/M Transition Circadian Clock RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs RAF activation Signaling by MRAS-complex mutants
RBPMS	RNA binding protein, mRNA processing factor
RFC5	replication factor C subunit 5	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere Activation of ATR in response to replication stress PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Activity through Phosphorylation Polymerase switching G2/M DNA damage checkpoint
SCNM1	sodium channel modifier 1
SF3B4	splicing factor 3b subunit 4	mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
SHC3	SHC adaptor protein 3	Signalling to RAS Signalling to RAS RAF/MAP kinase cascade RET signaling
TACO1	translational activator of cytochrome c oxidase I	TP53 Regulates Metabolic Genes Respiratory electron transport
TADA2A	transcriptional adaptor 2A	HATs acetylate histones
TASOR2	transcription activation suppressor family member 2

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