Search Results for: NEK2

Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
EDRF1 erythroid differentiation regulatory factor 1
EIF4A2 eukaryotic translation initiation factor 4A2
  • ISG15 antiviral mechanism
  • L13a-mediated translational silencing of Ceruloplasmin expression
  • Deadenylation of mRNA
  • Translation initiation complex formation
  • Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
  • Ribosomal scanning and start codon recognition
  • GTP hydrolysis and joining of the 60S ribosomal subunit
FZR1 fizzy and cell division cycle 20 related 1
  • Autodegradation of Cdh1 by Cdh1:APC/C
  • SCF-beta-TrCP mediated degradation of Emi1
  • APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
  • Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
  • Regulation of APC/C activators between G1/S and early anaphase
  • Phosphorylation of Emi1
  • Senescence-Associated Secretory Phenotype (SASP)
  • CDK-mediated phosphorylation and removal of Cdc6
  • Cyclin A:Cdk2-associated events at S phase entry
  • Transcriptional Regulation by VENTX
  • Aberrant regulation of mitotic exit in cancer due to RB1 defects
  • Antigen processing: Ubiquitination & Proteasome degradation
GIT1 GIT ArfGAP 1
  • Ephrin signaling
  • Ephrin signaling
  • Activation of RAC1 downstream of NMDARs
IFT140 intraflagellar transport 140
  • Hedgehog 'off' state
  • Intraflagellar transport
IMMT inner membrane mitochondrial protein
  • Cristae formation
MAD1L1 mitotic arrest deficient 1 like 1
  • Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
  • Separation of Sister Chromatids
  • Resolution of Sister Chromatid Cohesion
  • RHO GTPases Activate Formins
  • Mitotic Prometaphase
  • EML4 and NUDC in mitotic spindle formation
MAPK1 mitogen-activated protein kinase 1
  • phospho-PLA2 pathway
  • RAF-independent MAPK1/3 activation
  • MAPK1 (ERK2) activation
  • Spry regulation of FGF signaling
  • Golgi Cisternae Pericentriolar Stack Reorganization
  • Frs2-mediated activation
  • ERK/MAPK targets
  • ERK/MAPK targets
  • ERKs are inactivated
  • Regulation of actin dynamics for phagocytic cup formation
  • Oxidative Stress Induced Senescence
  • Senescence-Associated Secretory Phenotype (SASP)
  • Oncogene Induced Senescence
  • Oncogene Induced Senescence
  • FCERI mediated MAPK activation
  • Regulation of HSF1-mediated heat shock response
  • NCAM signaling for neurite out-growth
  • Recycling pathway of L1
  • RSK activation
  • Signal transduction by L1
  • Activation of the AP-1 family of transcription factors
  • Thrombin signalling through proteinase activated receptors (PARs)
  • Negative regulation of FGFR1 signaling
  • Negative regulation of FGFR2 signaling
  • Negative regulation of FGFR3 signaling
  • Negative regulation of FGFR4 signaling
  • RHO GTPases Activate WASPs and WAVEs
  • RHO GTPases Activate NADPH Oxidases
  • RAF/MAP kinase cascade
  • MAP2K and MAPK activation
  • Negative feedback regulation of MAPK pathway
  • Negative regulation of MAPK pathway
  • Neutrophil degranulation
  • Signaling by moderate kinase activity BRAF mutants
  • Signaling by high-kinase activity BRAF mutants
  • Signaling by BRAF and RAF fusions
  • Paradoxical activation of RAF signaling by kinase inactive BRAF
  • PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
  • Signal attenuation
  • Advanced glycosylation endproduct receptor signaling
  • Gastrin-CREB signalling pathway via PKC and MAPK
  • ESR-mediated signaling
  • RUNX2 regulates osteoblast differentiation
  • Regulation of PTEN gene transcription
  • Regulation of the apoptosome activity
  • Estrogen-stimulated signaling through PRKCZ
  • Estrogen-dependent nuclear events downstream of ESR-membrane signaling
  • Estrogen-dependent nuclear events downstream of ESR-membrane signaling
  • Suppression of apoptosis
  • Signaling downstream of RAS mutants
  • Signaling by MAP2K mutants
  • Signaling by MAPK mutants
  • Signaling by RAF1 mutants
  • FCGR3A-mediated phagocytosis
  • Growth hormone receptor signaling
  • Acetylsalicylic acid
  • Minocycline
  • Isoprenaline
  • Arsenic trioxide
  • Olomoucine
  • Phosphonothreonine
  • Purvalanol
  • SB220025
  • Seliciclib
  • Perifosine
  • N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE
  • N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE
  • (S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE
  • (3R,5Z,8S,9S,11E)-8,9,16-TRIHYDROXY-14-METHOXY-3-METHYL-3,4,9,10-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,7(8H)-DIONE
  • 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE
  • (1aR,8S,13S,14S,15aR)-5,13,14-trihydroxy-3-methoxy-8-methyl-8,9,13,14,15,15a-hexahydro-6H-oxireno[k][2]benzoxacyclotetradecine-6,12(1aH)-dione
  • [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID
  • 4-[4-(4-Fluorophenyl)-2-[4-[(R)-methylsulfinyl]phenyl]-1H-imidazol-5-yl]pyridine
  • Turpentine
  • Ulixertinib
MCC MCC regulator of WNT signaling pathway
NDC80 NDC80 kinetochore complex component
  • Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
  • Separation of Sister Chromatids
  • Resolution of Sister Chromatid Cohesion
  • RHO GTPases Activate Formins
  • Mitotic Prometaphase
  • EML4 and NUDC in mitotic spindle formation
NEK11 NIMA related kinase 11
  • Dabrafenib
  • Fostamatinib
PDE4DIP phosphodiesterase 4D interacting protein
PPP1CA protein phosphatase 1 catalytic subunit alpha
  • Triglyceride catabolism
  • DARPP-32 events
  • Downregulation of TGF-beta receptor signaling
  • Circadian Clock
  • 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
PPP1CC protein phosphatase 1 catalytic subunit gamma
  • Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
  • Triglyceride catabolism
  • Downregulation of TGF-beta receptor signaling
  • Separation of Sister Chromatids
  • Resolution of Sister Chromatid Cohesion
  • Circadian Clock
  • RHO GTPases Activate Formins
  • RAF activation
  • Mitotic Prometaphase
  • EML4 and NUDC in mitotic spindle formation
  • Signaling by MRAS-complex mutants
  • 9,10-Deepithio-9,10-Didehydroacanthifolicin
  • Calyculin A
  • Motuporin
PPP1R2 protein phosphatase 1 regulatory inhibitor subunit 2
PRKN parkin RBR E3 ubiquitin protein ligase
  • PINK1-PRKN Mediated Mitophagy
  • Josephin domain DUBs
  • Aggrephagy
  • Amyloid fiber formation
  • Antigen processing: Ubiquitination & Proteasome degradation
  • Parkinson's disease (PD)
PTPRD protein tyrosine phosphatase receptor type D
  • Receptor-type tyrosine-protein phosphatases
  • Synaptic adhesion-like molecules
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
  • Signaling by BMP
  • Downregulation of TGF-beta receptor signaling
  • TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
  • Asymmetric localization of PCP proteins
  • Hedgehog 'on' state
  • Hedgehog 'on' state
  • Regulation of RUNX2 expression and activity
  • Regulation of RUNX2 expression and activity
  • Regulation of RUNX3 expression and activity
  • Antigen processing: Ubiquitination & Proteasome degradation
SPTBN4 spectrin beta, non-erythrocytic 4
  • NCAM signaling for neurite out-growth
  • NCAM signaling for neurite out-growth
  • Interaction between L1 and Ankyrins
  • Interaction between L1 and Ankyrins
  • RAF/MAP kinase cascade
  • COPI-mediated anterograde transport
TCF25 transcription factor 25

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