EP300 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
NUP98	nucleoporin 98 and 96 precursor
NUPR1	nuclear protein 1, transcriptional regulator
OLIG2	oligodendrocyte transcription factor 2
ORC2	origin recognition complex subunit 2	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
PAK2	p21 (RAC1) activated kinase 2	Nef and signal transduction Generation of second messenger molecules Regulation of PAK-2p34 activity by PS-GAP/RHG10 Regulation of activated PAK-2p34 by proteasome mediated degradation Stimulation of the cell death response by PAK-2p34 FCERI mediated MAPK activation FCERI mediated MAPK activation CD28 dependent Vav1 pathway Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 VEGFA-VEGFR2 Pathway Smooth Muscle Contraction VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Fostamatinib
PAX5	paired box 5	RUNX1 regulates transcription of genes involved in BCR signaling		Lymphoplasmacytic lymphoma
PAX6	paired box 6	Regulation of gene expression in beta cells Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Activation of anterior HOX genes in hindbrain development during early embryogenesis		Aniridia Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP) Ocular coloboma, including: Coloboma of iris choroid and retina (COI); Coloboma of optic nerve (COLON)
PAX8	paired box 8			Thyroid cancer Congenital nongoitrous hypothyroidism (CHNG)
PAXIP1	PAX interacting protein 1	Activation of anterior HOX genes in hindbrain development during early embryogenesis Nonhomologous End-Joining (NHEJ)
PCK2	phosphoenolpyruvate carboxykinase 2, mitochondrial	Gluconeogenesis
PCNA	proliferating cell nuclear antigen	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Transcription of E2F targets under negative control by DREAM complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand SUMOylation of DNA replication proteins Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand G1/S-Specific Transcription E3 ubiquitin ligases ubiquitinate target proteins	Liothyronine Acetylsalicylic acid
PDHX	pyruvate dehydrogenase complex component X	Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
PELP1	proline, glutamate and leucine rich protein 1	Major pathway of rRNA processing in the nucleolus and cytosol PTK6 Expression
PIAS1	protein inhibitor of activated STAT 1	SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins Formation of Incision Complex in GG-NER Regulation of IFNG signaling
PIAS3	protein inhibitor of activated STAT 3	SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER
PIN1	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	ISG15 antiviral mechanism RHO GTPases Activate NADPH Oxidases Regulation of TP53 Activity through Phosphorylation PI5P Regulates TP53 Acetylation Negative regulators of DDX58/IFIH1 signaling	Beta-(2-Naphthyl)-Alanine 3,6,9,12,15,18-HEXAOXAICOSANE
PLAGL1	PLAG1 like zinc finger 1	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain		Transient neonatal diabetes mellitus (TNDM)
PLG	plasminogen	Platelet degranulation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Signaling by PDGF Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Dissolution of Fibrin Clot	Alteplase Urokinase Reteplase Anistreplase Tenecteplase Streptokinase Tranexamic acid Aminocaproic acid Bicine Desmoteplase Aprotinin Copper Gabexate	Inherited thrombophilia
PLSCR1	phospholipid scramblase 1
PLSCR2	phospholipid scramblase 2

Search Results for: EP300