Search Results for: PALS2

Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
Novel ADGRA1 adhesion G protein-coupled receptor A1
Novel ARF5 ADP ribosylation factor 5
  • COPI-mediated anterograde transport
  • COPI-dependent Golgi-to-ER retrograde traffic
Novel MKRN2 makorin ring finger protein 2
Novel OSBPL3 oxysterol binding protein like 3
  • Synthesis of bile acids and bile salts
Novel PTF1A pancreas associated transcription factor 1a
  • Regulation of gene expression in early pancreatic precursor cells
  • Permanent neonatal diabetes mellitus (PNDM)
Novel TACR3 tachykinin receptor 3
  • Tachykinin receptors bind tachykinins
  • G alpha (q) signalling events
  • Osanetant
  • Talnetant
  • Pavinetant
  • Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)
AATF apoptosis antagonizing transcription factor
  • NRAGE signals death through JNK
ABCA1 ATP binding cassette subfamily A member 1
  • PPARA activates gene expression
  • Defective ABCA1 causes TGD
  • HDL assembly
  • NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
  • ATP
  • Glyburide
  • Probucol
  • Tangier disease
  • Hypoalphalipoproteinemia
ARHGAP18 Rho GTPase activating protein 18
  • Rho GTPase cycle
DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
  • ATF4 activates genes in response to endoplasmic reticulum stress
  • mRNA decay by 3' to 5' exoribonuclease
  • Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
  • Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
  • KSRP (KHSRP) binds and destabilizes mRNA
  • Major pathway of rRNA processing in the nucleolus and cytosol
DNM2 dynamin 2
  • Toll Like Receptor 4 (TLR4) Cascade
  • Retrograde neurotrophin signalling
  • Gap junction degradation
  • Formation of annular gap junctions
  • NOSTRIN mediated eNOS trafficking
  • MHC class II antigen presentation
  • Lysosome Vesicle Biogenesis
  • Golgi Associated Vesicle Biogenesis
  • Recycling pathway of L1
  • Clathrin-mediated endocytosis
  • NGF-stimulated transcription
  • Centronuclear myopathy
  • Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
DYNLRB1 dynein light chain roadblock-type 1
  • Intraflagellar transport
EIF3G eukaryotic translation initiation factor 3 subunit G
  • L13a-mediated translational silencing of Ceruloplasmin expression
  • Translation initiation complex formation
  • Formation of a pool of free 40S subunits
  • Formation of the ternary complex, and subsequently, the 43S complex
  • Ribosomal scanning and start codon recognition
  • GTP hydrolysis and joining of the 60S ribosomal subunit
EXOSC10 exosome component 10
  • Major pathway of rRNA processing in the nucleolus and cytosol
EXOSC2 exosome component 2
  • ATF4 activates genes in response to endoplasmic reticulum stress
  • mRNA decay by 3' to 5' exoribonuclease
  • Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
  • Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
  • KSRP (KHSRP) binds and destabilizes mRNA
  • Major pathway of rRNA processing in the nucleolus and cytosol
EXOSC4 exosome component 4
  • ATF4 activates genes in response to endoplasmic reticulum stress
  • mRNA decay by 3' to 5' exoribonuclease
  • Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
  • Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
  • KSRP (KHSRP) binds and destabilizes mRNA
  • Major pathway of rRNA processing in the nucleolus and cytosol
EXOSC5 exosome component 5
  • ATF4 activates genes in response to endoplasmic reticulum stress
  • mRNA decay by 3' to 5' exoribonuclease
  • Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
  • Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
  • KSRP (KHSRP) binds and destabilizes mRNA
  • Major pathway of rRNA processing in the nucleolus and cytosol
EXOSC6 exosome component 6
  • ATF4 activates genes in response to endoplasmic reticulum stress
  • mRNA decay by 3' to 5' exoribonuclease
  • Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
  • Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
  • KSRP (KHSRP) binds and destabilizes mRNA
  • Major pathway of rRNA processing in the nucleolus and cytosol
EXOSC7 exosome component 7
  • ATF4 activates genes in response to endoplasmic reticulum stress
  • mRNA decay by 3' to 5' exoribonuclease
  • Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
  • Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
  • KSRP (KHSRP) binds and destabilizes mRNA
  • Major pathway of rRNA processing in the nucleolus and cytosol
EXOSC8 exosome component 8
  • ATF4 activates genes in response to endoplasmic reticulum stress
  • mRNA decay by 3' to 5' exoribonuclease
  • Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
  • Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
  • KSRP (KHSRP) binds and destabilizes mRNA
  • Major pathway of rRNA processing in the nucleolus and cytosol

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