LMO4 and DYNC1H1

Data Source:
BioGRID (biochemical)

		LMO4	DYNC1H1
Description		LIM domain only 4	dynein cytoplasmic 1 heavy chain 1
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GO Annotations	Cellular Component	Transcription Regulator Complex Cell Leading Edge RNA Polymerase II Transcription Regulator Complex	Extracellular Region Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Cytoplasmic Microtubule Cell Cortex Membrane Dynein Complex Azurophil Granule Lumen Extracellular Exosome Axon Cytoplasm
	Molecular Function	Protein Binding Transcription Factor Binding Metal Ion Binding	RNA Binding Protein Binding ATP Binding ATP-dependent Microtubule Motor Activity, Minus-end-directed Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding
	Biological Process	Neural Tube Closure Ventricular Septum Development Ventral Spinal Cord Interneuron Differentiation Spinal Cord Motor Neuron Differentiation Spinal Cord Association Neuron Differentiation Regulation Of Cell Migration Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Kinase Activity Regulation Of Cell Fate Specification Positive Regulation Of Transcription By RNA Polymerase II Thymus Development Regulation Of Cell Activation	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Microtubule-based Movement Mitotic Spindle Organization Nuclear Migration Retrograde Axonal Transport Regulation Of G2/M Transition Of Mitotic Cell Cycle Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cytoplasmic Microtubule Organization Positive Regulation Of Intracellular Transport P-body Assembly Stress Granule Assembly Neutrophil Degranulation Establishment Of Spindle Localization Cell Division Regulation Of Mitotic Spindle Organization Minus-end-directed Vesicle Transport Along Microtubule Regulation Of Metaphase Plate Congression Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Spindle Assembly
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases			Distal hereditary motor neuropathies (dHMN)
GWAS		Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Breast cancer ( 27354352) Eosinophil counts ( 29403010) Gait rhythm ( 26219847) Glaucoma (primary open-angle) ( 29891935) Photic sneeze reflex ( 27182965) Prostate-specific antigen levels ( 28139693) Response to TNF antagonist treatment ( 18615156) Resting heart rate ( 27798624) White blood cell count (basophil) ( 29403010) White blood cell types ( 21738478)	Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143)
Interacting Genes		130 interacting genes: AARD ABI2 ADAMTSL4 AMOT AMOTL2 ARNT2 BANP BBS2 BCAS2 BIRC7 BRCA1 C12orf40 CALCOCO2 CCDC102B CCDC120 CEP170P1 COG6 CRNN CRYBB2 CSNK2B CTBP2 CYSRT1 DDB1 DEAF1 DES ECM1 ERCC6L EXOSC8 FAM228A FHL3 GABPB1 GADD45A GOLGA2 GOLGA6L9 GRHL2 GSK3B HELT HGS HSF2BP ID3 IKZF1 IKZF3 ITSN1 KANK2 KATNBL1 KIAA1958 KIF3B KPNA1 KRT15 KRT31 KRT33B KRT34 KRT38 KRT39 KRT40 KRT74 KRT75 KRT76 KRTAP11-1 KRTAP3-1 KYNU L3MBTL3 LASP1 LDB1 LDB2 LMO2 LZTS1 MCCD1 MERTK METTL27 MID2 MTA1 MTUS2 MYOD1 MYOZ3 N4BP3 NFKBID NFYC NHLH1 NME4 NONO NRF1 PDE4DIP PELO PER2 PITPNB PLK1 PPARG PPP1R32 QRICH1 RBAK RBBP8 RBPMS RCN1 RNF8 ROPN1 RPS6KA6 RSPH6A SEC24D SLC15A2 SMAD4 SMAD9 STAT5B SUOX TCF21 TCF4 TEX14 TFIP11 TINAGL1 TLE5 TNFSF11 TP53BP2 TRAF5 TRIM27 TRIM54 TSEN15 TTLL7 UBQLN2 VMAC VPS52 WASHC1 ZBTB43 ZMYND12 ZNF135 ZNF202 ZNF213 ZNF397 ZNF410 ZNF467 ZNF675	19 interacting genes: BRCA1 COX20 DISC1 DUX4 DYNLL1 EGFR KATNA1 KATNB1 LINC01554 MTNR1B NDEL1 PRKCD RHBDD2 SMAD2 SUMO2 TENT5A TNIK YWHAG YWHAQ
Entrez ID		8543	1778
HPRD ID		09122	02524
Ensembl ID		ENSG00000143013	ENSG00000197102
Uniprot IDs		P61968	Q14204
PDB IDs		2L4Z	2BOR 2BOT 5NUG 5OWO 6F1T 6F1U 6F1V 6F1Y 6F38 6F3A
Enriched GO Terms of Interacting Partners?
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