MVK and EIF4E2

Data Source:
BioGRID (affinity chromatography technology)

		MVK	EIF4E2
Description		mevalonate kinase	eukaryotic translation initiation factor 4E family member 2
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GO Annotations	Cellular Component	Peroxisome Cytosol Intracellular Membrane-bounded Organelle	P-body Cytoplasm Cytosol MRNA Cap Binding Complex Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	Magnesium Ion Binding Mevalonate Kinase Activity Protein Binding ATP Binding Identical Protein Binding	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Ubiquitin Protein Ligase Binding
	Biological Process	Cholesterol Biosynthetic Process Isoprenoid Biosynthetic Process Phosphorylation Isopentenyl Diphosphate Biosynthetic Process, Mevalonate Pathway Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Inflammatory Response	Translational Initiation Negative Regulation Of Translation Gene Silencing By RNA Positive Regulation Of MiRNA Mediated Inhibition Of Translation
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)	ISG15 antiviral mechanism
Drugs		Farnesyl thiopyrophosphate
Diseases		Mevalonate kinase deficiency; Hyperimmunoglobulinemia D; Mevalonic aciduria
GWAS		Aspartate aminotransferase levels ( 29403010) Fish- and plant-related diet ( 32066663) HDL cholesterol ( 24097068 18193043 20864672 19060906 30275531 25961943 20686565) HDL cholesterol levels ( 28334899) High density lipoprotein cholesterol levels ( 29403010) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494) Neutrophil count ( 29403010) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Red cell distribution width ( 28957414)	Height ( 25282103) Non-small cell lung cancer (survival) ( 21079520) Refractive error ( 32231278)
Interacting Genes		4 interacting genes: EWSR1 POT1 RNF141 TERF1	45 interacting genes: ADAMTSL4 AMOTL2 APP ARIH1 CARD9 CBY2 CDR2 EIF4EBP1 EIF4EBP3 EIF4ENIF1 FBXO25 GIGYF1 HOMEZ KRT13 KRT19 KRT20 KRT31 KRT40 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-12 LZTS2 MAGED1 MAPRE3 MDFI MGAT5B MIPOL1 MYOG NECAB2 NOTCH2NLA PRDM14 REL SPAG5 SPRY2 TADA2A TCF4 TLE5 TMCC2 TRIM27 TRIM54 UBXN11 USHBP1 USP54 ZBTB9
Entrez ID		4598	9470
HPRD ID		02015	05798
Ensembl ID		ENSG00000110921	ENSG00000135930
Uniprot IDs		B2RDU6 B7Z301 F5H8H2 Q03426	B8ZZ50 B8ZZL3 B9A023 O60573 Q53RG0 Q59FE1
PDB IDs		2R3V	2JGB 2JGC 5NVK 5NVL 5NVM 5NVN 5XLN
Enriched GO Terms of Interacting Partners?
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