HPCA and DPYD

Data Source:
BioGRID (two hybrid)

		HPCA	DPYD
Description		hippocalcin	dihydropyrimidine dehydrogenase
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extrinsic Component Of Membrane Axon Dendrite Membrane Neuronal Cell Body Membrane Dendrite Cytoplasm Perikaryon Dendritic Spine Head Glutamatergic Synapse	Cytoplasm Cytosol
	Molecular Function	Actin Binding Calcium Ion Binding Protein Binding Kinase Binding Identical Protein Binding	Uracil Binding Protein Binding Dihydropyrimidine Dehydrogenase (NADP+) Activity Protein Homodimerization Activity Metal Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Brain Development Calcium-mediated Signaling Negative Regulation Of Guanylate Cyclase Activity Activation Of Phospholipase D Activity Positive Regulation Of Adenylate Cyclase Activity Inner Ear Development Retina Development In Camera-type Eye Cellular Response To Electrical Stimulus Cellular Response To Calcium Ion Positive Regulation Of Protein Targeting To Membrane Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Regulation Of Voltage-gated Calcium Channel Activity Response To Ketamine Response To L-glutamate Cellular Response To Monosodium Glutamate Response To Aroclor 1254	Purine Nucleobase Catabolic Process Pyrimidine Nucleobase Catabolic Process Thymine Catabolic Process Uracil Catabolic Process Thymidine Catabolic Process Beta-alanine Biosynthetic Process UMP Catabolic Process DUMP Catabolic Process Pyrimidine Nucleoside Catabolic Process
Pathways			Pyrimidine catabolism
Drugs			(5S)-5-Iododihydro-2,4(1H,3H)-pyrimidinedione NADPH 6-Carboxymethyluracil Flavin adenine dinucleotide Flavin mononucleotide Uracil Eniluracil 5-Iodouracil Gimeracil Tegafur-uracil
Diseases			Dihydropyrimidine dehydrogenase deficiency
GWAS			Adult body size ( 32376654) Adverse response to drug ( 30420678) Anthropometric traits (multi-trait analysis) ( 30166351) Anxiety/tension (special factor of neuroticism) ( 30867560) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Body mass index ( 25673413 29273807) Borderline personality disorder ( 28632202) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Extremely high intelligence ( 29520040) Face memory ( 31596458) Feeling nervous ( 29500382) Gastroesophageal reflux disease ( 31527586) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Irritable mood ( 29500382) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483) Methadone dose in opioid dependence ( 28115739) Platelet count ( 21507922) Regular attendance at a pub or social club ( 29970889) Schizophrenia ( 25056061 29483656 22688191 30285260 23974872) Sleep duration ( 30531941) Sleep duration (short sleep) ( 30846698) Triglyceride levels ( 32203549 32154731) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		16 interacting genes: C1QTNF2 CKMT1A CKMT1B CREM DTX2 GATA5 IL36RN MLLT10 MYDGF NAIP NMT1 PRR35 SLC16A3 TEPSIN UQCRB VWC2	3 interacting genes: CLK1 GOPC LXN
Entrez ID		3208	1806
HPRD ID		00811	02036
Ensembl ID		ENSG00000121905	ENSG00000188641
Uniprot IDs		P84074	Q12882
PDB IDs		5G4P 5G58 5M6C
Enriched GO Terms of Interacting Partners?
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