EXOSC2 and MTX2

Data Source:
BioGRID (imaging technique)

		EXOSC2	MTX2
Description		exosome component 2	metaxin 2
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol	SAM Complex Nucleolus Cytoplasm Mitochondrion Mitochondrial Outer Membrane MIB Complex
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding 7S RNA Binding	Protein Binding
	Biological Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription Polyadenylation-dependent SnoRNA 3'-end Processing	Mitochondrial Transport Mitochondrion Organization Inner Mitochondrial Membrane Organization Protein Transport
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	Mitochondrial protein import Cristae formation
Drugs
Diseases
GWAS			Blond vs. brown/black hair color ( 30531825) Blood urea nitrogen levels ( 31152163) Chin dimples ( 27182965) Chronic kidney disease ( 31152163) Estimated glomerular filtration rate in non-diabetics ( 31451708) Eye morphology ( 29921221) Male-pattern baldness ( 27182965 28196072) Monobrow ( 27182965) Upper eyelid morphology ( 29921221) Urate levels ( 31578528)
Interacting Genes		18 interacting genes: DIS3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 GALNT13 KHSRP MRPL48 MTREX PALS2 PTEN RNF8 SBK3 ST6GALNAC1 UPF1 ZNF408	6 interacting genes: C1QTNF2 KASH5 MTX1 RHOH TADA2A UBQLN2
Entrez ID		23404	10651
HPRD ID		03758	09777
Ensembl ID		ENSG00000130713	ENSG00000128654
Uniprot IDs		B3KQW2 Q13868	O75431
PDB IDs		2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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