RSPO1

Description		R-spondin 1
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GO Annotations	Cellular Component	Extracellular Region Nucleus
	Molecular Function	G Protein-coupled Receptor Binding Signaling Receptor Binding Protein Binding Heparin Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Regulation Of Receptor Internalization Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Regulation of FZD by ubiquitination
Drugs
Diseases		46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
GWAS		Axial length ( 24144296) Epithelial ovarian cancer ( 25581431) Eyebrow thickness ( 26926045) Intraocular pressure ( 29785010 31959993 30054594)
Interacting Genes		2 interacting genes: LGR4 ZNRF3
Entrez ID		284654
HPRD ID		08288
Ensembl ID		ENSG00000169218
Uniprot IDs		Q2MKA7
PDB IDs		4BSO 4BSP 4BSR 4BSS 4BST 4BSU 4CDK 4KNG 4KT1 4LI2 4QXF
Enriched GO Terms of Interacting Partners?
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