EPGN

Description		epithelial mitogen
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Integral Component Of Plasma Membrane Clathrin-coated Vesicle Membrane
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	MAPK Cascade Activation Of MAPK Activity Angiogenesis Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Kinase B Signaling Membrane Organization
Pathways		PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs
Diseases
GWAS		Breast size ( 22747683) Immune reponse to smallpox (secreted IL-1beta) ( 22610502)
Interacting Genes		4 interacting genes: ADAM33 CXCL9 MTIF3 TIMMDC1
Entrez ID		255324
HPRD ID		10866
Ensembl ID		ENSG00000182585
Uniprot IDs		Q6UW88
PDB IDs		5WB8
Enriched GO Terms of Interacting Partners?
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