CYP11B1

Description		cytochrome P450 family 11 subfamily B member 1
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane
	Molecular Function	Steroid 11-beta-monooxygenase Activity Iron Ion Binding Heme Binding Corticosterone 18-monooxygenase Activity
	Biological Process	C21-steroid Hormone Biosynthetic Process Glucocorticoid Biosynthetic Process Immune Response Cholesterol Metabolic Process Regulation Of Blood Pressure Sterol Metabolic Process Aldosterone Biosynthetic Process Cellular Response To Hormone Stimulus Cortisol Metabolic Process Cortisol Biosynthetic Process Cellular Response To Potassium Ion Glucose Homeostasis Cellular Response To Peptide Hormone Stimulus
Pathways		Glucocorticoid biosynthesis Endogenous sterols Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
Drugs		Mitotane Metyrapone Levoketoconazole Osilodrostat
Diseases		Glucocorticoid-remediable aldosteronism (GRA) Congenital adrenal hyperplasia (CAH) 46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency
GWAS		Hypertension ( 30487518) Mean arterial pressure ( 30487518) Pulse pressure ( 30487518) Systolic blood pressure ( 29403010)
Interacting Genes		1 interacting genes: CYP11B2
Entrez ID		1584
HPRD ID		01943
Ensembl ID		ENSG00000160882
Uniprot IDs		P15538 Q8TDD0
PDB IDs		6M7X
Enriched GO Terms of Interacting Partners?
Tagcloud ?