GRK3 and CXCR4 |
G protein-coupled receptor kinase 3 |
C-X-C motif chemokine receptor 4 |
- G alpha (s) signalling events
- Cargo recognition for clathrin-mediated endocytosis
|
- Binding and entry of HIV virion
- Signaling by ROBO receptors
- Chemokine receptors bind chemokines
- G alpha (i) signalling events
|
|
- Framycetin
- AMD-070
- Plerixafor
|
|
- Chemokine receptor defect, including the following disease: WHIM syndrome
|
GRK3 and CCR5 |
G protein-coupled receptor kinase 3 |
C-C motif chemokine receptor 5 (gene/pseudogene) |
- G alpha (s) signalling events
- Cargo recognition for clathrin-mediated endocytosis
|
- Binding and entry of HIV virion
- Chemokine receptors bind chemokines
- G alpha (i) signalling events
- Interleukin-10 signaling
|
|
- Maraviroc
- AMD-070
- INCB-9471
|
|
|
GRK3 and HSPB1 |
G protein-coupled receptor kinase 3 |
heat shock protein family B (small) member 1 |
- G alpha (s) signalling events
- Cargo recognition for clathrin-mediated endocytosis
|
- VEGFA-VEGFR2 Pathway
- AUF1 (hnRNP D0) binds and destabilizes mRNA
- MAPK6/MAPK4 signaling
- Extra-nuclear estrogen signaling
|
|
- Apatorsen
- Phenethyl Isothiocyanate
|
|
- Distal hereditary motor neuropathies (dHMN)
|
AP2A1 and HIP1 |
adaptor related protein complex 2 subunit alpha 1 |
huntingtin interacting protein 1 |
- Nef Mediated CD4 Down-regulation
- Retrograde neurotrophin signalling
- Retrograde neurotrophin signalling
- Nef Mediated CD8 Down-regulation
- MHC class II antigen presentation
- EPH-ephrin mediated repulsion of cells
- Trafficking of GluR2-containing AMPA receptors
- Recycling pathway of L1
- Recycling pathway of L1
- WNT5A-dependent internalization of FZD4
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- VLDLR internalisation and degradation
- LDL clearance
|
- Clathrin-mediated endocytosis
|
|
|
|
|
AP2A1 and SYT7 |
adaptor related protein complex 2 subunit alpha 1 |
synaptotagmin 7 |
- Nef Mediated CD4 Down-regulation
- Retrograde neurotrophin signalling
- Retrograde neurotrophin signalling
- Nef Mediated CD8 Down-regulation
- MHC class II antigen presentation
- EPH-ephrin mediated repulsion of cells
- Trafficking of GluR2-containing AMPA receptors
- Recycling pathway of L1
- Recycling pathway of L1
- WNT5A-dependent internalization of FZD4
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- VLDLR internalisation and degradation
- LDL clearance
|
- Neurexins and neuroligins
|
|
|
|
|
AP2A1 and SNAP29 |
adaptor related protein complex 2 subunit alpha 1 |
synaptosome associated protein 29 |
- Nef Mediated CD4 Down-regulation
- Retrograde neurotrophin signalling
- Retrograde neurotrophin signalling
- Nef Mediated CD8 Down-regulation
- MHC class II antigen presentation
- EPH-ephrin mediated repulsion of cells
- Trafficking of GluR2-containing AMPA receptors
- Recycling pathway of L1
- Recycling pathway of L1
- WNT5A-dependent internalization of FZD4
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- VLDLR internalisation and degradation
- LDL clearance
|
- Neutrophil degranulation
- Intra-Golgi traffic
|
|
|
|
- Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome; CEDNIK syndrome
|
AP2A1 and GHR |
adaptor related protein complex 2 subunit alpha 1 |
growth hormone receptor |
- Nef Mediated CD4 Down-regulation
- Retrograde neurotrophin signalling
- Retrograde neurotrophin signalling
- Nef Mediated CD8 Down-regulation
- MHC class II antigen presentation
- EPH-ephrin mediated repulsion of cells
- Trafficking of GluR2-containing AMPA receptors
- Recycling pathway of L1
- Recycling pathway of L1
- WNT5A-dependent internalization of FZD4
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- VLDLR internalisation and degradation
- LDL clearance
|
- Prolactin receptor signaling
- Growth hormone receptor signaling
- Growth hormone receptor signaling
|
|
|
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- Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
|
AP2A1 and PICALM |
adaptor related protein complex 2 subunit alpha 1 |
phosphatidylinositol binding clathrin assembly protein |
- Nef Mediated CD4 Down-regulation
- Retrograde neurotrophin signalling
- Retrograde neurotrophin signalling
- Nef Mediated CD8 Down-regulation
- MHC class II antigen presentation
- EPH-ephrin mediated repulsion of cells
- Trafficking of GluR2-containing AMPA receptors
- Recycling pathway of L1
- Recycling pathway of L1
- WNT5A-dependent internalization of FZD4
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- VLDLR internalisation and degradation
- LDL clearance
|
- Golgi Associated Vesicle Biogenesis
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
|
|
|
|
|
AP2A1 and SYNJ1 |
adaptor related protein complex 2 subunit alpha 1 |
synaptojanin 1 |
- Nef Mediated CD4 Down-regulation
- Retrograde neurotrophin signalling
- Retrograde neurotrophin signalling
- Nef Mediated CD8 Down-regulation
- MHC class II antigen presentation
- EPH-ephrin mediated repulsion of cells
- Trafficking of GluR2-containing AMPA receptors
- Recycling pathway of L1
- Recycling pathway of L1
- WNT5A-dependent internalization of FZD4
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- VLDLR internalisation and degradation
- LDL clearance
|
- Synthesis of PIPs at the plasma membrane
- Synthesis of IP2, IP, and Ins in the cytosol
- Synthesis of IP3 and IP4 in the cytosol
- Clathrin-mediated endocytosis
|
|
|
|
|
AP2A1 and TOE1 |
adaptor related protein complex 2 subunit alpha 1 |
target of EGR1, exonuclease |
- Nef Mediated CD4 Down-regulation
- Retrograde neurotrophin signalling
- Retrograde neurotrophin signalling
- Nef Mediated CD8 Down-regulation
- MHC class II antigen presentation
- EPH-ephrin mediated repulsion of cells
- Trafficking of GluR2-containing AMPA receptors
- Recycling pathway of L1
- Recycling pathway of L1
- WNT5A-dependent internalization of FZD4
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- VLDLR internalisation and degradation
- LDL clearance
|
|
|
|
|
|
AP2A1 and PIN1 |
adaptor related protein complex 2 subunit alpha 1 |
peptidylprolyl cis/trans isomerase, NIMA-interacting 1 |
- Nef Mediated CD4 Down-regulation
- Retrograde neurotrophin signalling
- Retrograde neurotrophin signalling
- Nef Mediated CD8 Down-regulation
- MHC class II antigen presentation
- EPH-ephrin mediated repulsion of cells
- Trafficking of GluR2-containing AMPA receptors
- Recycling pathway of L1
- Recycling pathway of L1
- WNT5A-dependent internalization of FZD4
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- VLDLR internalisation and degradation
- LDL clearance
|
- ISG15 antiviral mechanism
- RHO GTPases Activate NADPH Oxidases
- Regulation of TP53 Activity through Phosphorylation
- PI5P Regulates TP53 Acetylation
- Negative regulators of DDX58/IFIH1 signaling
|
|
- Beta-(2-Naphthyl)-Alanine
- 3,6,9,12,15,18-HEXAOXAICOSANE
|
|
|
AP2A1 and EHD1 |
adaptor related protein complex 2 subunit alpha 1 |
EH domain containing 1 |
- Nef Mediated CD4 Down-regulation
- Retrograde neurotrophin signalling
- Retrograde neurotrophin signalling
- Nef Mediated CD8 Down-regulation
- MHC class II antigen presentation
- EPH-ephrin mediated repulsion of cells
- Trafficking of GluR2-containing AMPA receptors
- Recycling pathway of L1
- Recycling pathway of L1
- WNT5A-dependent internalization of FZD4
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- VLDLR internalisation and degradation
- LDL clearance
|
- Factors involved in megakaryocyte development and platelet production
|
|
|
|
|
AP2A1 and EPN1 |
adaptor related protein complex 2 subunit alpha 1 |
epsin 1 |
- Nef Mediated CD4 Down-regulation
- Retrograde neurotrophin signalling
- Retrograde neurotrophin signalling
- Nef Mediated CD8 Down-regulation
- MHC class II antigen presentation
- EPH-ephrin mediated repulsion of cells
- Trafficking of GluR2-containing AMPA receptors
- Recycling pathway of L1
- Recycling pathway of L1
- WNT5A-dependent internalization of FZD4
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- VLDLR internalisation and degradation
- LDL clearance
|
- EGFR downregulation
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
|
|
- 1,4-Diethylene Dioxide
- 1D-myo-inositol 1,4,5-trisphosphate
|
|
|
AP2A1 and DEK |
adaptor related protein complex 2 subunit alpha 1 |
DEK proto-oncogene |
- Nef Mediated CD4 Down-regulation
- Retrograde neurotrophin signalling
- Retrograde neurotrophin signalling
- Nef Mediated CD8 Down-regulation
- MHC class II antigen presentation
- EPH-ephrin mediated repulsion of cells
- Trafficking of GluR2-containing AMPA receptors
- Recycling pathway of L1
- Recycling pathway of L1
- WNT5A-dependent internalization of FZD4
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- VLDLR internalisation and degradation
- LDL clearance
|
- B-WICH complex positively regulates rRNA expression
- Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
- Transcriptional regulation of granulopoiesis
- Transcriptional regulation of granulopoiesis
|
|
|
|
|
AP2A1 and DNM2 |
adaptor related protein complex 2 subunit alpha 1 |
dynamin 2 |
- Nef Mediated CD4 Down-regulation
- Retrograde neurotrophin signalling
- Retrograde neurotrophin signalling
- Nef Mediated CD8 Down-regulation
- MHC class II antigen presentation
- EPH-ephrin mediated repulsion of cells
- Trafficking of GluR2-containing AMPA receptors
- Recycling pathway of L1
- Recycling pathway of L1
- WNT5A-dependent internalization of FZD4
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- VLDLR internalisation and degradation
- LDL clearance
|
- Toll Like Receptor 4 (TLR4) Cascade
- Retrograde neurotrophin signalling
- Gap junction degradation
- Formation of annular gap junctions
- NOSTRIN mediated eNOS trafficking
- MHC class II antigen presentation
- Lysosome Vesicle Biogenesis
- Golgi Associated Vesicle Biogenesis
- Recycling pathway of L1
- Clathrin-mediated endocytosis
- NGF-stimulated transcription
|
|
|
|
- Centronuclear myopathy
- Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
|
AP2A1 and DPYSL2 |
adaptor related protein complex 2 subunit alpha 1 |
dihydropyrimidinase like 2 |
- Nef Mediated CD4 Down-regulation
- Retrograde neurotrophin signalling
- Retrograde neurotrophin signalling
- Nef Mediated CD8 Down-regulation
- MHC class II antigen presentation
- EPH-ephrin mediated repulsion of cells
- Trafficking of GluR2-containing AMPA receptors
- Recycling pathway of L1
- Recycling pathway of L1
- WNT5A-dependent internalization of FZD4
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- VLDLR internalisation and degradation
- LDL clearance
|
- CRMPs in Sema3A signaling
- Recycling pathway of L1
|
|
|
|
|
AP2A1 and BIN1 |
adaptor related protein complex 2 subunit alpha 1 |
bridging integrator 1 |
- Nef Mediated CD4 Down-regulation
- Retrograde neurotrophin signalling
- Retrograde neurotrophin signalling
- Nef Mediated CD8 Down-regulation
- MHC class II antigen presentation
- EPH-ephrin mediated repulsion of cells
- Trafficking of GluR2-containing AMPA receptors
- Recycling pathway of L1
- Recycling pathway of L1
- WNT5A-dependent internalization of FZD4
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- VLDLR internalisation and degradation
- LDL clearance
|
- Clathrin-mediated endocytosis
|
|
|
|
|
AP2A1 and SYT3 |
adaptor related protein complex 2 subunit alpha 1 |
synaptotagmin 3 |
- Nef Mediated CD4 Down-regulation
- Retrograde neurotrophin signalling
- Retrograde neurotrophin signalling
- Nef Mediated CD8 Down-regulation
- MHC class II antigen presentation
- EPH-ephrin mediated repulsion of cells
- Trafficking of GluR2-containing AMPA receptors
- Recycling pathway of L1
- Recycling pathway of L1
- WNT5A-dependent internalization of FZD4
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- VLDLR internalisation and degradation
- LDL clearance
|
|
|
|
|
|
AP2A1 and RAB11FIP2 |
adaptor related protein complex 2 subunit alpha 1 |
RAB11 family interacting protein 2 |
- Nef Mediated CD4 Down-regulation
- Retrograde neurotrophin signalling
- Retrograde neurotrophin signalling
- Nef Mediated CD8 Down-regulation
- MHC class II antigen presentation
- EPH-ephrin mediated repulsion of cells
- Trafficking of GluR2-containing AMPA receptors
- Recycling pathway of L1
- Recycling pathway of L1
- WNT5A-dependent internalization of FZD4
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- VLDLR internalisation and degradation
- LDL clearance
|
- Vasopressin regulates renal water homeostasis via Aquaporins
|
|
|
|
|
AP2A1 and SHBG |
adaptor related protein complex 2 subunit alpha 1 |
sex hormone binding globulin |
- Nef Mediated CD4 Down-regulation
- Retrograde neurotrophin signalling
- Retrograde neurotrophin signalling
- Nef Mediated CD8 Down-regulation
- MHC class II antigen presentation
- EPH-ephrin mediated repulsion of cells
- Trafficking of GluR2-containing AMPA receptors
- Recycling pathway of L1
- Recycling pathway of L1
- WNT5A-dependent internalization of FZD4
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- VLDLR internalisation and degradation
- LDL clearance
|
|
|
- Masoprocol
- Diethylstilbestrol
- Levonorgestrel
- Progesterone
- Spironolactone
- Toremifene
- Estrone
- Tamoxifen
- Clomifene
- Dienestrol
- Ethinyl Estradiol
- Hesperetin
- Zinc
- Genistein
- Naringenin
- Quercetin
- 4'-Hydroxyflavanone
- Afimoxifene
- Estriol
- Phenolphthalein
- Equol
|
|
|