ACTA1 and ITGA2 |
actin alpha 1, skeletal muscle |
integrin subunit alpha 2 |
- Striated Muscle Contraction
|
- Integrin cell surface interactions
- Integrin cell surface interactions
- Laminin interactions
- Laminin interactions
- Syndecan interactions
- ECM proteoglycans
- CHL1 interactions
- Platelet Adhesion to exposed collagen
- MET activates PTK2 signaling
|
- Latrunculin A
- Sucrose
- Ulapualide A
- Kabiramide C
- Jaspisamide A
- Tmr
- 4-Methyl-Histidine
- Phosphoaminophosphonic Acid-Adenylate Ester
- Aplyronine A
- Reidispongiolide A
- Reidispongiolide C
- Sphinxolide B
- LATRUNCULIN B
|
|
- Congenital fiber type disproportion (CFTD)
- Cap myopathy
- Nemaline myopathy
|
|
ACTA1 and TTN |
actin alpha 1, skeletal muscle |
titin |
- Striated Muscle Contraction
|
- Platelet degranulation
- Striated Muscle Contraction
|
- Latrunculin A
- Sucrose
- Ulapualide A
- Kabiramide C
- Jaspisamide A
- Tmr
- 4-Methyl-Histidine
- Phosphoaminophosphonic Acid-Adenylate Ester
- Aplyronine A
- Reidispongiolide A
- Reidispongiolide C
- Sphinxolide B
- LATRUNCULIN B
|
|
- Congenital fiber type disproportion (CFTD)
- Cap myopathy
- Nemaline myopathy
|
- Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)
- Hypertrophic cardiomyopathy (HCM)
- Dilated cardiomyopathy (DCM)
|
ACTA1 and PARVA |
actin alpha 1, skeletal muscle |
parvin alpha |
- Striated Muscle Contraction
|
- Localization of the PINCH-ILK-PARVIN complex to focal adhesions
- Cell-extracellular matrix interactions
- Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
|
- Latrunculin A
- Sucrose
- Ulapualide A
- Kabiramide C
- Jaspisamide A
- Tmr
- 4-Methyl-Histidine
- Phosphoaminophosphonic Acid-Adenylate Ester
- Aplyronine A
- Reidispongiolide A
- Reidispongiolide C
- Sphinxolide B
- LATRUNCULIN B
|
|
- Congenital fiber type disproportion (CFTD)
- Cap myopathy
- Nemaline myopathy
|
|
ACTA1 and DHX9 |
actin alpha 1, skeletal muscle |
DExH-box helicase 9 |
- Striated Muscle Contraction
|
- RIP-mediated NFkB activation via ZBP1
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- mRNA Splicing - Major Pathway
|
- Latrunculin A
- Sucrose
- Ulapualide A
- Kabiramide C
- Jaspisamide A
- Tmr
- 4-Methyl-Histidine
- Phosphoaminophosphonic Acid-Adenylate Ester
- Aplyronine A
- Reidispongiolide A
- Reidispongiolide C
- Sphinxolide B
- LATRUNCULIN B
|
|
- Congenital fiber type disproportion (CFTD)
- Cap myopathy
- Nemaline myopathy
|
|
ACTA1 and EGFR |
actin alpha 1, skeletal muscle |
epidermal growth factor receptor |
- Striated Muscle Contraction
|
- Signaling by ERBB2
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- Signaling by ERBB4
- SHC1 events in ERBB2 signaling
- SHC1 events in ERBB2 signaling
- PLCG1 events in ERBB2 signaling
- PIP3 activates AKT signaling
- Signaling by EGFR
- GRB2 events in EGFR signaling
- GAB1 signalosome
- SHC1 events in EGFR signaling
- EGFR downregulation
- GRB2 events in ERBB2 signaling
- PI3K events in ERBB2 signaling
- EGFR interacts with phospholipase C-gamma
- EGFR Transactivation by Gastrin
- Constitutive Signaling by Aberrant PI3K in Cancer
- Signal transduction by L1
- Constitutive Signaling by EGFRvIII
- Inhibition of Signaling by Overexpressed EGFR
- RAF/MAP kinase cascade
- ERBB2 Regulates Cell Motility
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
- ERBB2 Activates PTK6 Signaling
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- PTK6 promotes HIF1A stabilization
- Downregulation of ERBB2 signaling
- TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
- Extra-nuclear estrogen signaling
- NOTCH3 Activation and Transmission of Signal to the Nucleus
- HCMV Early Events
- Estrogen-dependent nuclear events downstream of ESR-membrane signaling
- Signaling by ERBB2 KD Mutants
- Signaling by ERBB2 ECD mutants
- Signaling by ERBB2 TMD/JMD mutants
|
- Latrunculin A
- Sucrose
- Ulapualide A
- Kabiramide C
- Jaspisamide A
- Tmr
- 4-Methyl-Histidine
- Phosphoaminophosphonic Acid-Adenylate Ester
- Aplyronine A
- Reidispongiolide A
- Reidispongiolide C
- Sphinxolide B
- LATRUNCULIN B
|
- Cetuximab
- Trastuzumab
- Lidocaine
- Gefitinib
- Erlotinib
- Lapatinib
- Panitumumab
- Alvocidib
- IGN311
- Matuzumab
- Vandetanib
- Rindopepimut
- Canertinib
- Pelitinib
- Varlitinib
- S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE
- N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE
- Afatinib
- Osimertinib
- Necitumumab
- Depatuxizumab mafodotin
- Icotinib
- Neratinib
- Zalutumumab
- Brigatinib
- Olmutinib
|
- Congenital fiber type disproportion (CFTD)
- Cap myopathy
- Nemaline myopathy
|
- Choriocarcinoma
- Gastric cancer
- Bladder cancer
- Oral cancer
- Glioma
- Laryngeal cancer
- Cervical cancer
- Esophageal cancer
|
ACTA1 and UBC |
actin alpha 1, skeletal muscle |
ubiquitin C |
- Striated Muscle Contraction
|
- Translesion synthesis by REV1
- Recognition of DNA damage by PCNA-containing replication complex
- Translesion Synthesis by POLH
- Activation of NF-kappaB in B cells
- ISG15 antiviral mechanism
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- ER-Phagosome pathway
- Downregulation of ERBB4 signaling
- Spry regulation of FGF signaling
- Downregulation of ERBB2:ERBB3 signaling
- Budding and maturation of HIV virion
- NOD1/2 Signaling Pathway
- TICAM1, RIP1-mediated IKK complex recruitment
- DDX58/IFIH1-mediated induction of interferon-alpha/beta
- APC/C:Cdc20 mediated degradation of Cyclin B
- Autodegradation of Cdh1 by Cdh1:APC/C
- SCF-beta-TrCP mediated degradation of Emi1
- APC/C:Cdc20 mediated degradation of Securin
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A
- Membrane binding and targetting of GAG proteins
- Assembly Of The HIV Virion
- APC-Cdc20 mediated degradation of Nek2A
- Vpu mediated degradation of CD4
- Vif-mediated degradation of APOBEC3G
- EGFR downregulation
- SCF(Skp2)-mediated degradation of p27/p21
- Degradation of beta-catenin by the destruction complex
- TCF dependent signaling in response to WNT
- Downstream TCR signaling
- NRIF signals cell death from the nucleus
- p75NTR recruits signalling complexes
- NF-kB is activated and signals survival
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- NOTCH1 Intracellular Domain Regulates Transcription
- Activated NOTCH1 Transmits Signal to the Nucleus
- Activated NOTCH1 Transmits Signal to the Nucleus
- Downregulation of TGF-beta receptor signaling
- Downregulation of TGF-beta receptor signaling
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Separation of Sister Chromatids
- Oxidative Stress Induced Senescence
- Senescence-Associated Secretory Phenotype (SASP)
- Oncogene Induced Senescence
- Regulation of PLK1 Activity at G2/M Transition
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Stimuli-sensing channels
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- FCERI mediated NF-kB activation
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- Regulation of innate immune responses to cytosolic DNA
- Glycogen synthesis
- Autodegradation of the E3 ubiquitin ligase COP1
- Deactivation of the beta-catenin transactivating complex
- Myoclonic epilepsy of Lafora
- ABC-family proteins mediated transport
- Circadian Clock
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- activated TAK1 mediates p38 MAPK activation
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- AUF1 (hnRNP D0) binds and destabilizes mRNA
- Asymmetric localization of PCP proteins
- Degradation of AXIN
- Degradation of DVL
- Regulation of FZD by ubiquitination
- Pink/Parkin Mediated Mitophagy
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Regulation of TNFR1 signaling
- TNFR1-induced NFkappaB signaling pathway
- Hedgehog ligand biogenesis
- Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
- Dectin-1 mediated noncanonical NF-kB signaling
- CLEC7A (Dectin-1) signaling
- Degradation of GLI1 by the proteasome
- Degradation of GLI2 by the proteasome
- GLI3 is processed to GLI3R by the proteasome
- Hedgehog 'on' state
- Hedgehog 'on' state
- Negative regulation of FGFR1 signaling
- Negative regulation of FGFR2 signaling
- Negative regulation of FGFR3 signaling
- Negative regulation of FGFR4 signaling
- Translesion synthesis by POLK
- Translesion synthesis by POLI
- Termination of translesion DNA synthesis
- Regulation of RAS by GAPs
- TNFR2 non-canonical NF-kB pathway
- Negative regulation of MAPK pathway
- Regulation of necroptotic cell death
- NIK - noncanonical NF-kB signaling
- Defective CFTR causes cystic fibrosis
- MAP3K8 (TPL2)-dependent MAPK1/3 activation
- HDR through Homologous Recombination (HRR)
- MAPK6/MAPK4 signaling
- UCH proteinases
- UCH proteinases
- Josephin domain DUBs
- Ub-specific processing proteases
- Ovarian tumor domain proteases
- Metalloprotease DUBs
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Processing of DNA double-strand break ends
- DNA Damage Recognition in GG-NER
- Formation of Incision Complex in GG-NER
- Gap-filling DNA repair synthesis and ligation in GG-NER
- Dual Incision in GG-NER
- Formation of TC-NER Pre-Incision Complex
- Transcription-Coupled Nucleotide Excision Repair (TC-NER)
- Dual incision in TC-NER
- Gap-filling DNA repair synthesis and ligation in TC-NER
- Fanconi Anemia Pathway
- Regulation of TP53 Activity through Phosphorylation
- Regulation of TP53 Degradation
- Regulation of TP53 Activity through Methylation
- Negative regulation of MET activity
- CDT1 association with the CDC6:ORC:origin complex
- Orc1 removal from chromatin
- CDK-mediated phosphorylation and removal of Cdc6
- Cyclin D associated events in G1
- G2/M Checkpoints
- Stabilization of p53
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- Ubiquitin-dependent degradation of Cyclin D
- PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
- The role of GTSE1 in G2/M progression after G2 checkpoint
- FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- Downregulation of ERBB2 signaling
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- E3 ubiquitin ligases ubiquitinate target proteins
- InlB-mediated entry of Listeria monocytogenes into host cell
- InlB-mediated entry of Listeria monocytogenes into host cell
- InlA-mediated entry of Listeria monocytogenes into host cells
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
- Regulation of RUNX2 expression and activity
- Regulation of RUNX2 expression and activity
- Regulation of RUNX3 expression and activity
- Regulation of PTEN localization
- Regulation of PTEN stability and activity
- Neddylation
- ER Quality Control Compartment (ERQC)
- Regulation of expression of SLITs and ROBOs
- Regulation of expression of SLITs and ROBOs
- NOTCH3 Activation and Transmission of Signal to the Nucleus
- NOTCH3 Activation and Transmission of Signal to the Nucleus
- TICAM1-dependent activation of IRF3/IRF7
- TICAM1,TRAF6-dependent induction of TAK1 complex
- Interleukin-1 signaling
- Peroxisomal protein import
- Peroxisomal protein import
- Regulation of signaling by CBL
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Iron uptake and transport
- Negative regulators of DDX58/IFIH1 signaling
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- IRAK1 recruits IKK complex
- IKK complex recruitment mediated by RIP1
- IRAK2 mediated activation of TAK1 complex
- TRAF6-mediated induction of TAK1 complex within TLR4 complex
- Negative regulation of NOTCH4 signaling
- Chaperone Mediated Autophagy
- Late endosomal microautophagy
- Prevention of phagosomal-lysosomal fusion
- Modulation by Mtb of host immune system
- Alpha-protein kinase 1 signaling pathway
- Aggrephagy
- Aggrephagy
- Pexophagy
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
- Amyloid fiber formation
- Antigen processing: Ubiquitination & Proteasome degradation
|
- Latrunculin A
- Sucrose
- Ulapualide A
- Kabiramide C
- Jaspisamide A
- Tmr
- 4-Methyl-Histidine
- Phosphoaminophosphonic Acid-Adenylate Ester
- Aplyronine A
- Reidispongiolide A
- Reidispongiolide C
- Sphinxolide B
- LATRUNCULIN B
|
|
- Congenital fiber type disproportion (CFTD)
- Cap myopathy
- Nemaline myopathy
|
|
ACTA1 and RAC1 |
actin alpha 1, skeletal muscle |
Rac family small GTPase 1 |
- Striated Muscle Contraction
|
- GPVI-mediated activation cascade
- PIP3 activates AKT signaling
- Signaling by SCF-KIT
- Translocation of SLC2A4 (GLUT4) to the plasma membrane
- Nef and signal transduction
- NRAGE signals death through JNK
- Rho GTPase cycle
- Regulation of actin dynamics for phagocytic cup formation
- Regulation of actin dynamics for phagocytic cup formation
- Constitutive Signaling by Aberrant PI3K in Cancer
- DAP12 signaling
- FCERI mediated MAPK activation
- DSCAM interactions
- CD28 dependent Vav1 pathway
- EPHB-mediated forward signaling
- Ephrin signaling
- EPH-ephrin mediated repulsion of cells
- Sema3A PAK dependent Axon repulsion
- SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
- PCP/CE pathway
- Sema4D mediated inhibition of cell attachment and migration
- DCC mediated attractive signaling
- DCC mediated attractive signaling
- Activation of RAC1
- Inactivation of CDC42 and RAC1
- VEGFA-VEGFR2 Pathway
- Signal transduction by L1
- VEGFR2 mediated vascular permeability
- RHO GTPases activate PKNs
- RHO GTPases activate CIT
- RHO GTPases activate CIT
- RHO GTPases activate KTN1
- RHO GTPases activate IQGAPs
- RHO GTPases activate PAKs
- RHO GTPases Activate WASPs and WAVEs
- RHO GTPases Activate WASPs and WAVEs
- RHO GTPases Activate Formins
- RHO GTPases Activate Formins
- RHO GTPases Activate NADPH Oxidases
- MAPK6/MAPK4 signaling
- Neutrophil degranulation
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
- PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
- MET activates RAP1 and RAC1
- NTRK2 activates RAC1
- Activated NTRK2 signals through CDK5
- Activation of RAC1 downstream of NMDARs
- FCGR3A-mediated phagocytosis
- FCGR3A-mediated phagocytosis
- WNT5:FZD7-mediated leishmania damping
- Factors involved in megakaryocyte development and platelet production
|
- Latrunculin A
- Sucrose
- Ulapualide A
- Kabiramide C
- Jaspisamide A
- Tmr
- 4-Methyl-Histidine
- Phosphoaminophosphonic Acid-Adenylate Ester
- Aplyronine A
- Reidispongiolide A
- Reidispongiolide C
- Sphinxolide B
- LATRUNCULIN B
|
- Dextromethorphan
- Azathioprine
- Guanosine-5'-Diphosphate
|
- Congenital fiber type disproportion (CFTD)
- Cap myopathy
- Nemaline myopathy
|
|
ACTA1 and CCT5 |
actin alpha 1, skeletal muscle |
chaperonin containing TCP1 subunit 5 |
- Striated Muscle Contraction
|
- Prefoldin mediated transfer of substrate to CCT/TriC
- Formation of tubulin folding intermediates by CCT/TriC
- Folding of actin by CCT/TriC
- Association of TriC/CCT with target proteins during biosynthesis
- Association of TriC/CCT with target proteins during biosynthesis
- BBSome-mediated cargo-targeting to cilium
- Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
|
- Latrunculin A
- Sucrose
- Ulapualide A
- Kabiramide C
- Jaspisamide A
- Tmr
- 4-Methyl-Histidine
- Phosphoaminophosphonic Acid-Adenylate Ester
- Aplyronine A
- Reidispongiolide A
- Reidispongiolide C
- Sphinxolide B
- LATRUNCULIN B
|
|
- Congenital fiber type disproportion (CFTD)
- Cap myopathy
- Nemaline myopathy
|
|
ACTA2 and MYOC |
actin alpha 2, smooth muscle |
myocilin |
- Smooth Muscle Contraction
- NOTCH4 Intracellular Domain Regulates Transcription
|
|
|
|
- Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
|
|
ACTA2 and GC |
actin alpha 2, smooth muscle |
GC vitamin D binding protein |
- Smooth Muscle Contraction
- NOTCH4 Intracellular Domain Regulates Transcription
|
- Vitamin D (calciferol) metabolism
|
|
|
- Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
|
|
ACTA2 and UBE3A |
actin alpha 2, smooth muscle |
ubiquitin protein ligase E3A |
- Smooth Muscle Contraction
- NOTCH4 Intracellular Domain Regulates Transcription
|
- Antigen processing: Ubiquitination & Proteasome degradation
|
|
|
- Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
|
- Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
|
ACTA2 and PRKCD |
actin alpha 2, smooth muscle |
protein kinase C delta |
- Smooth Muscle Contraction
- NOTCH4 Intracellular Domain Regulates Transcription
|
- Apoptotic cleavage of cellular proteins
- Calmodulin induced events
- Effects of PIP2 hydrolysis
- SHC1 events in ERBB2 signaling
- DAG and IP3 signaling
- Role of phospholipids in phagocytosis
- G alpha (z) signalling events
- HuR (ELAVL1) binds and stabilizes mRNA
- VEGFR2 mediated cell proliferation
- CLEC7A (Dectin-1) signaling
- RHO GTPases Activate NADPH Oxidases
- Neutrophil degranulation
- Interferon gamma signaling
|
|
- Tamoxifen
- 13-Acetylphorbol
- Ingenol Mebutate
|
- Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
|
|
ACTA2 and DNASE1 |
actin alpha 2, smooth muscle |
deoxyribonuclease 1 |
- Smooth Muscle Contraction
- NOTCH4 Intracellular Domain Regulates Transcription
|
|
|
|
- Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
|
|
ACTA2 and PCYT1B |
actin alpha 2, smooth muscle |
phosphate cytidylyltransferase 1, choline, beta |
- Smooth Muscle Contraction
- NOTCH4 Intracellular Domain Regulates Transcription
|
|
|
|
- Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
|
|
ACTA2 and SELE |
actin alpha 2, smooth muscle |
selectin E |
- Smooth Muscle Contraction
- NOTCH4 Intracellular Domain Regulates Transcription
|
- Cell surface interactions at the vascular wall
|
|
- Carvedilol
- N-acetyl-alpha-neuraminic acid
|
- Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
|
|
ACTA2 and MYL1 |
actin alpha 2, smooth muscle |
myosin light chain 1 |
- Smooth Muscle Contraction
- NOTCH4 Intracellular Domain Regulates Transcription
|
- Striated Muscle Contraction
|
|
|
- Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
|
|
ACTA2 and YBX1 |
actin alpha 2, smooth muscle |
Y-box binding protein 1 |
- Smooth Muscle Contraction
- NOTCH4 Intracellular Domain Regulates Transcription
|
- mRNA Splicing - Major Pathway
- mRNA Splicing - Minor Pathway
- Noncanonical activation of NOTCH3
|
|
|
- Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
|
|
ACTA2 and MINK1 |
actin alpha 2, smooth muscle |
misshapen like kinase 1 |
- Smooth Muscle Contraction
- NOTCH4 Intracellular Domain Regulates Transcription
|
- Oxidative Stress Induced Senescence
|
|
|
- Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
|
|
ACTA2 and SHBG |
actin alpha 2, smooth muscle |
sex hormone binding globulin |
- Smooth Muscle Contraction
- NOTCH4 Intracellular Domain Regulates Transcription
|
|
|
- Masoprocol
- Diethylstilbestrol
- Levonorgestrel
- Progesterone
- Spironolactone
- Toremifene
- Estrone
- Tamoxifen
- Clomifene
- Dienestrol
- Ethinyl Estradiol
- Hesperetin
- Zinc
- Genistein
- Naringenin
- Quercetin
- 4'-Hydroxyflavanone
- Afimoxifene
- Estriol
- Phenolphthalein
- Equol
|
- Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
|
|
ACTA2 and CCT4 |
actin alpha 2, smooth muscle |
chaperonin containing TCP1 subunit 4 |
- Smooth Muscle Contraction
- NOTCH4 Intracellular Domain Regulates Transcription
|
- Prefoldin mediated transfer of substrate to CCT/TriC
- Formation of tubulin folding intermediates by CCT/TriC
- Folding of actin by CCT/TriC
- Association of TriC/CCT with target proteins during biosynthesis
- Association of TriC/CCT with target proteins during biosynthesis
- BBSome-mediated cargo-targeting to cilium
- Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
|
|
|
- Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
|
|