Virus - Wiki-CORONA

Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
ARF1 and EEF1G	ADP ribosylation factor 1	eukaryotic translation elongation factor 1 gamma	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Nef Mediated CD4 Down-regulation trans-Golgi Network Vesicle Budding MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Eukaryotic Translation Elongation	1,3-Propandiol Guanosine-3'-Monophosphate-5'-Diphosphate Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate Brefeldin A Myristic acid Glycerin
AXL and TYRO3	AXL receptor tyrosine kinase	TYRO3 protein tyrosine kinase	VEGFA-VEGFR2 Pathway
AXL and EGFR	AXL receptor tyrosine kinase	epidermal growth factor receptor	VEGFA-VEGFR2 Pathway	Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PLCG1 events in ERBB2 signaling PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma EGFR Transactivation by Gastrin Constitutive Signaling by Aberrant PI3K in Cancer Signal transduction by L1 Constitutive Signaling by EGFRvIII Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis PTK6 promotes HIF1A stabilization Downregulation of ERBB2 signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Extra-nuclear estrogen signaling NOTCH3 Activation and Transmission of Signal to the Nucleus HCMV Early Events Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants		Cetuximab Trastuzumab Lidocaine Gefitinib Erlotinib Lapatinib Panitumumab Alvocidib IGN311 Matuzumab Vandetanib Rindopepimut Canertinib Pelitinib Varlitinib S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE Afatinib Osimertinib Necitumumab Depatuxizumab mafodotin Icotinib Neratinib Zalutumumab Brigatinib Olmutinib		Choriocarcinoma Gastric cancer Bladder cancer Oral cancer Glioma Laryngeal cancer Cervical cancer Esophageal cancer
AXL and SRC	AXL receptor tyrosine kinase	SRC proto-oncogene, non-receptor tyrosine kinase	VEGFA-VEGFR2 Pathway	Signaling by ERBB2 Nuclear signaling by ERBB4 Downregulation of ERBB4 signaling PIP3 activates AKT signaling GAB1 signalosome Downstream signal transduction Constitutive Signaling by Aberrant PI3K in Cancer Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events DCC mediated attractive signaling DCC mediated attractive signaling Netrin mediated repulsion signals Regulation of commissural axon pathfinding by SLIT and ROBO RAF activation MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates PTK2 signaling InlA-mediated entry of Listeria monocytogenes into host cells Regulation of RUNX1 Expression and Activity RUNX2 regulates osteoblast differentiation Regulation of RUNX3 expression and activity Extra-nuclear estrogen signaling Activated NTRK2 signals through FYN Activated NTRK3 signals through PI3K Activated NTRK3 signals through PI3K Long-term potentiation Signaling downstream of RAS mutants		Dasatinib RU84687 RU79256 N6-Benzyl Adenosine-5'-Diphosphate RU85493 RU78262 Phosphonotyrosine Malonic acid RU83876 RU90395 RU79072 RU78783 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine PASBN RU82129 PAS219 DPI59 RU82197 Phenylphosphate RU78300 RU79073 RU82209 ISO24 RU85053 RU78299 Oxalic Acid RU78191 Citric Acid RU81843 4-[(4-METHYL-1-PIPERAZINYL)METHYL]-N-[3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]PHENYL]-BENZAMIDE Purvalanol A XL228 Bosutinib 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-phenylurea 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 1-cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 1-(1-methylethyl)-3-quinolin-6-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 2-(4-CARCOXY-5-ISOPROPYLTHIAZOLYL)BENZOPIPERIDINE N-(4-PHENYLAMINO-QUINAZOLIN-6-YL)-ACRYLAMIDE (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide Ponatinib Nintedanib
AXL and GAS6	AXL receptor tyrosine kinase	growth arrest specific 6	VEGFA-VEGFR2 Pathway	Platelet degranulation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
AXL and LCK	AXL receptor tyrosine kinase	LCK proto-oncogene, Src family tyrosine kinase	VEGFA-VEGFR2 Pathway	GPVI-mediated activation cascade PIP3 activates AKT signaling Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling Nef and signal transduction Nef Mediated CD4 Down-regulation Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules PECAM1 interactions Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling DAP12 signaling CD28 co-stimulation CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway CTLA4 inhibitory signaling PD-1 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-2 signaling		Dasatinib {4-[2-Acetylamino-2-(3-Carbamoyl-2-Cyclohexylmethoxy-6,7,8,9-Tetrahydro-5h-Benzocyclohepten-5ylcarbamoyl)-Ethyl]-2-Phosphono-Phenyl}-Phosphonic Acid Staurosporine 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine (4-{2-Acetylamino-2-[1-(3-Carbamoyl-4-Cyclohexylmethoxy-Phenyl)-Ethylcarbamoyl}-Ethyl}-2-Phosphono-Phenoxy)-Acetic Acid Phosphoaminophosphonic Acid-Adenylate Ester 3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE 2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE 5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine Ponatinib Nintedanib		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
AZU1 and CLEC4G	azurocidin 1	C-type lectin domain family 4 member G	Neutrophil degranulation	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
B2M and HLA-B	beta-2-microglobulin	major histocompatibility complex, class I, B	ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Nef mediated downregulation of MHC class I complex cell surface expression Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling DAP12 signaling Neutrophil degranulation Interferon gamma signaling Modulation by Mtb of host immune system Amyloid fiber formation Antigen Presentation: Folding, assembly and peptide loading of class I MHC	ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation Interferon gamma signaling Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Doxycycline 3-Indolebutyric Acid N-Formylmethionine Copper
B2M and CXCR4	beta-2-microglobulin	C-X-C motif chemokine receptor 4	ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Nef mediated downregulation of MHC class I complex cell surface expression Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling DAP12 signaling Neutrophil degranulation Interferon gamma signaling Modulation by Mtb of host immune system Amyloid fiber formation Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Binding and entry of HIV virion Signaling by ROBO receptors Chemokine receptors bind chemokines G alpha (i) signalling events	Doxycycline 3-Indolebutyric Acid N-Formylmethionine Copper	Framycetin AMD-070 Plerixafor		Chemokine receptor defect, including the following disease: WHIM syndrome
B2M and LILRB1	beta-2-microglobulin	leukocyte immunoglobulin like receptor B1	ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Nef mediated downregulation of MHC class I complex cell surface expression Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling DAP12 signaling Neutrophil degranulation Interferon gamma signaling Modulation by Mtb of host immune system Amyloid fiber formation Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Doxycycline 3-Indolebutyric Acid N-Formylmethionine Copper
BAD and PIM2	BCL2 associated agonist of cell death	Pim-2 proto-oncogene, serine/threonine kinase	Activation of BAD and translocation to mitochondria Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members NRAGE signals death through JNK AKT phosphorylates targets in the cytosol Constitutive Signaling by AKT1 E17K in Cancer		Navitoclax
BAD and BCL2	BCL2 associated agonist of cell death	BCL2 apoptosis regulator	Activation of BAD and translocation to mitochondria Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members NRAGE signals death through JNK AKT phosphorylates targets in the cytosol Constitutive Signaling by AKT1 E17K in Cancer	Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-4 and Interleukin-13 signaling The NLRP1 inflammasome Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling	Navitoclax	Ibuprofen Paclitaxel Docetaxel Rasagiline S-8184 Paclitaxel docosahexaenoic acid Glycine betaine Eribulin Dexibuprofen Venetoclax Obatoclax Navitoclax		Choriocarcinoma Gastric cancer Chronic lymphocytic leukemia (CLL) Small cell lung cancer Kaposi's sarcoma Nasopharyngeal cancer Cervical cancer
BAD and BCL2L1	BCL2 associated agonist of cell death	BCL2 like 1	Activation of BAD and translocation to mitochondria Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members NRAGE signals death through JNK AKT phosphorylates targets in the cytosol Constitutive Signaling by AKT1 E17K in Cancer	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-4 and Interleukin-13 signaling The NLRP1 inflammasome	Navitoclax	4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID Gossypol
BCL2 and BCL2L1	BCL2 apoptosis regulator	BCL2 like 1	Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-4 and Interleukin-13 signaling The NLRP1 inflammasome Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-4 and Interleukin-13 signaling The NLRP1 inflammasome	Ibuprofen Paclitaxel Docetaxel Rasagiline S-8184 Paclitaxel docosahexaenoic acid Glycine betaine Eribulin Dexibuprofen Venetoclax Obatoclax Navitoclax	4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID Gossypol	Choriocarcinoma Gastric cancer Chronic lymphocytic leukemia (CLL) Small cell lung cancer Kaposi's sarcoma Nasopharyngeal cancer Cervical cancer
BCL2 and BNIP3	BCL2 apoptosis regulator	BCL2 interacting protein 3	Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-4 and Interleukin-13 signaling The NLRP1 inflammasome Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling		Ibuprofen Paclitaxel Docetaxel Rasagiline S-8184 Paclitaxel docosahexaenoic acid Glycine betaine Eribulin Dexibuprofen Venetoclax Obatoclax Navitoclax		Choriocarcinoma Gastric cancer Chronic lymphocytic leukemia (CLL) Small cell lung cancer Kaposi's sarcoma Nasopharyngeal cancer Cervical cancer
BCL2 and BNIP3L	BCL2 apoptosis regulator	BCL2 interacting protein 3 like	Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-4 and Interleukin-13 signaling The NLRP1 inflammasome Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	Ibuprofen Paclitaxel Docetaxel Rasagiline S-8184 Paclitaxel docosahexaenoic acid Glycine betaine Eribulin Dexibuprofen Venetoclax Obatoclax Navitoclax		Choriocarcinoma Gastric cancer Chronic lymphocytic leukemia (CLL) Small cell lung cancer Kaposi's sarcoma Nasopharyngeal cancer Cervical cancer
BCL2 and NMT2	BCL2 apoptosis regulator	N-myristoyltransferase 2	Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-4 and Interleukin-13 signaling The NLRP1 inflammasome Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling	Membrane binding and targetting of GAG proteins Inactivation, recovery and regulation of the phototransduction cascade	Ibuprofen Paclitaxel Docetaxel Rasagiline S-8184 Paclitaxel docosahexaenoic acid Glycine betaine Eribulin Dexibuprofen Venetoclax Obatoclax Navitoclax	Myristoyl-Coa S-(2-Oxo)Pentadecylcoa 1-(CYCLOHEXYLAMINO)-3-(6-METHYL-3,4-DIHYDRO-1H-CARBAZOL-9(2H)-YL)PROPAN-2-OL (Z)-3-BENZYL-5-(2-HYDROXY-3-NITROBENZYLIDENE)-2-THIOXOTHIAZOLIDIN-4-ONE	Choriocarcinoma Gastric cancer Chronic lymphocytic leukemia (CLL) Small cell lung cancer Kaposi's sarcoma Nasopharyngeal cancer Cervical cancer
BCL2 and HSPA1A	BCL2 apoptosis regulator	heat shock protein family A (Hsp70) member 1A	Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-4 and Interleukin-13 signaling The NLRP1 inflammasome Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling	Viral RNP Complexes in the Host Cell Nucleus Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase HSF1-dependent transactivation AUF1 (hnRNP D0) binds and destabilizes mRNA Neutrophil degranulation Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase HSF1-dependent transactivation Neutrophil degranulation	Ibuprofen Paclitaxel Docetaxel Rasagiline S-8184 Paclitaxel docosahexaenoic acid Glycine betaine Eribulin Dexibuprofen Venetoclax Obatoclax Navitoclax		Choriocarcinoma Gastric cancer Chronic lymphocytic leukemia (CLL) Small cell lung cancer Kaposi's sarcoma Nasopharyngeal cancer Cervical cancer
BCL2 and PMAIP1	BCL2 apoptosis regulator	phorbol-12-myristate-13-acetate-induced protein 1	Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-4 and Interleukin-13 signaling The NLRP1 inflammasome Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling	Activation of NOXA and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	Ibuprofen Paclitaxel Docetaxel Rasagiline S-8184 Paclitaxel docosahexaenoic acid Glycine betaine Eribulin Dexibuprofen Venetoclax Obatoclax Navitoclax		Choriocarcinoma Gastric cancer Chronic lymphocytic leukemia (CLL) Small cell lung cancer Kaposi's sarcoma Nasopharyngeal cancer Cervical cancer
BCL2 and PML	BCL2 apoptosis regulator	promyelocytic leukemia	Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-4 and Interleukin-13 signaling The NLRP1 inflammasome Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling	SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Regulation of TP53 Activity through Acetylation Interferon gamma signaling Regulation of RUNX1 Expression and Activity Regulation of PTEN localization HCMV Early Events	Ibuprofen Paclitaxel Docetaxel Rasagiline S-8184 Paclitaxel docosahexaenoic acid Glycine betaine Eribulin Dexibuprofen Venetoclax Obatoclax Navitoclax	Arsenic trioxide	Choriocarcinoma Gastric cancer Chronic lymphocytic leukemia (CLL) Small cell lung cancer Kaposi's sarcoma Nasopharyngeal cancer Cervical cancer	Acute myeloid leukemia (AML)

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