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BUB1

Description BUB1 mitotic checkpoint serine/threonine kinase
Image
GO Annotations Cellular Component
  • Kinetochore
  • Condensed Chromosome Kinetochore
  • Condensed Nuclear Chromosome Kinetochore
  • Condensed Nuclear Chromosome Outer Kinetochore
  • Nucleoplasm
  • Cytosol
  • Membrane
Molecular Function
  • Protein Kinase Activity
  • Protein Serine/threonine Kinase Activity
  • Protein Binding
  • ATP Binding
Biological Process
  • Protein Phosphorylation
  • Apoptotic Process
  • Regulation Of Sister Chromatid Cohesion
  • Mitotic Cell Cycle Checkpoint
  • Mitotic Spindle Assembly Checkpoint
  • Cell Proliferation
  • Viral Process
  • Cell Division
  • Meiotic Sister Chromatid Cohesion, Centromeric
  • Regulation Of Chromosome Segregation
Pathways
  • Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
  • Separation of Sister Chromatids
  • Resolution of Sister Chromatid Cohesion
  • RHO GTPases Activate Formins
  • Mitotic Prometaphase
  • EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS
Interacting Genes 18 interacting genes: AP1B1 AP2B1 AP3B1 AP4B1 APC ARIH2 BUB3 CDC20 CDK1 CRK EIF4EBP1 FBXO7 HDAC1 KNL1 PLK1 RAE1 RDH12 SVIL
Entrez ID 699
HPRD ID 03907
Ensembl ID ENSG00000169679
Uniprot IDs B4DYG2 O43683
PDB IDs 2LAH 4A1G 4QPM 4R8Q 5DMZ 6F7B
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025

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