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RRM2

Description ribonucleotide reductase regulatory subunit M2
Image
GO Annotations Cellular Component
  • Cytosol
  • Ribonucleoside-diphosphate Reductase Complex
Molecular Function
  • Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor
  • Protein Binding
  • Ferric Iron Binding
  • Protein Homodimerization Activity
Biological Process
  • Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
  • DNA Replication
  • Deoxyribonucleotide Biosynthetic Process
  • Nucleobase-containing Small Molecule Interconversion
  • Protein Heterotetramerization
  • Oxidation-reduction Process
  • Negative Regulation Of G0 To G1 Transition
Pathways
  • Interconversion of nucleotide di- and triphosphates
  • G1/S-Specific Transcription
  • Transcriptional Regulation by E2F6
Drugs
  • Cladribine
  • Imexon
  • Gallium nitrate
  • motexafin gadolinium
  • GTI 2040
Diseases
GWAS
  • Kidney function decline traits ( 25493955)
  • Prostate cancer ( 23535732)
Interacting Genes 8 interacting genes: CDH1 CDK1 DNM1L KAT5 PLK3 RRM1 RRM2B TP53
Entrez ID 6241
HPRD ID 01587
Ensembl ID ENSG00000171848
Uniprot IDs P31350
PDB IDs 2UW2 3OLJ 3VPM 3VPN 3VPO
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025

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