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SIGIRR

Description single Ig and TIR domain containing
Image No pdb structure
GO Annotations Cellular Component
  • Plasma Membrane
  • Membrane
  • Integral Component Of Membrane
Molecular Function
  • Protein Binding
Biological Process
  • Negative Regulation Of Cytokine-mediated Signaling Pathway
  • Acute-phase Response
  • Signal Transduction
  • Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway
  • Negative Regulation Of DNA-binding Transcription Factor Activity
  • Negative Regulation Of Chemokine Biosynthetic Process
  • Cellular Response To Cytokine Stimulus
Pathways
  • MyD88:MAL(TIRAP) cascade initiated on plasma membrane
  • Interleukin-37 signaling
Drugs
Diseases
GWAS
Interacting Genes 9 interacting genes: APP ENO2 IL1R1 IRAK1 RPN1 TLR4 TLR5 TLR9 TRAF6
Entrez ID 59307
HPRD ID 12018
Ensembl ID ENSG00000185187
Uniprot IDs C9JFX4 Q6IA17
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?

© Madhavi K. Ganapathiraju 2012-2025

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