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SH2D1A

Description SH2 domain containing 1A
Image
GO Annotations Cellular Component
  • Cytoplasm
  • Cytosol
Molecular Function
  • SH3/SH2 Adaptor Activity
  • Protein Binding
Biological Process
  • Adaptive Immune Response
  • Humoral Immune Response
  • Cellular Defense Response
  • Cell-cell Signaling
  • Positive Regulation Of Signal Transduction
  • Innate Immune Response
  • Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
  • Regulation Of Immune Response
Pathways
  • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
  • Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS
Interacting Genes 26 interacting genes: ARHGEF6 ARHGEF7 ATF3 CCDC74A CD84 DOK1 EGFR ERBB3 FYB1 FYN GRB2 LCK LETMD1 LHX4 LY9 MAPK11 MAPK14 NCK1 NGEF OLIG1 PTK2 SLAMF1 SLAMF6 SLAMF7 TNK2 ZNHIT1
Entrez ID 4068
HPRD ID 02390
Ensembl ID ENSG00000183918
Uniprot IDs O60880
PDB IDs 1D1Z 1D4T 1D4W 1KA6 1KA7 1M27
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025

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