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AHCY

Description adenosylhomocysteinase
Image
GO Annotations Cellular Component
  • Nucleus
  • Cytosol
  • Melanosome
  • Neuron Projection
  • Extracellular Exosome
Molecular Function
  • Adenosylhomocysteinase Activity
  • Protein Binding
  • Adenyl Nucleotide Binding
  • Identical Protein Binding
  • NAD Binding
Biological Process
  • Sulfur Amino Acid Metabolic Process
  • Response To Hypoxia
  • Chronic Inflammatory Response To Antigenic Stimulus
  • One-carbon Metabolic Process
  • Response To Nutrient
  • S-adenosylhomocysteine Catabolic Process
  • Methylation
  • S-adenosylmethionine Cycle
  • Circadian Sleep/wake Cycle
Pathways
  • Methylation
  • Sulfur amino acid metabolism
  • Metabolism of ingested SeMet, Sec, MeSec into H2Se
  • Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
Drugs
  • Isopropyl Alcohol
  • (1'r,2's)-9-(2-Hydroxy-3'-Keto-Cyclopenten-1-Yl)Adenine
  • 3'-Oxo-Adenosine
  • D-Eritadenine
  • Copper
Diseases
  • Hypermethioninemia; Methionine adenosyltransferase deficiency; S-adenosylhomocysteine hydrolase deficiency
GWAS
  • Heel bone mineral density ( 30598549)
  • Height ( 28552196)
  • Vitiligo ( 27723757)
Interacting Genes 7 interacting genes: ANKRD40 APPBP2 C1orf50 POT1 PXN TERF1 YWHAQ
Entrez ID 191
HPRD ID 01621
Ensembl ID ENSG00000101444
Uniprot IDs A0A384MTQ3 P23526 Q1RMG2
PDB IDs 1A7A 1LI4 3NJ4 4PFJ 4PGF 4YVF 5W49 5W4B
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025

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