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DPAGT1

Description dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
Image
GO Annotations Cellular Component
  • Endoplasmic Reticulum Membrane
  • Membrane
  • Integral Component Of Membrane
  • Integral Component Of Endoplasmic Reticulum Membrane
  • Intracellular Membrane-bounded Organelle
Molecular Function
  • UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase Activity
  • UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase Activity
  • Phospho-N-acetylmuramoyl-pentapeptide-transferase Activity
  • Transferase Activity, Transferring Glycosyl Groups
  • Identical Protein Binding
  • Metal Ion Binding
Biological Process
  • UDP-N-acetylglucosamine Metabolic Process
  • Protein N-linked Glycosylation
  • Dolichol-linked Oligosaccharide Biosynthetic Process
  • Dolichyl Diphosphate Biosynthetic Process
  • Dolichol Metabolic Process
Pathways
  • Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
  • Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
Drugs
Diseases
  • Congenital disorders of glycosylation (CDG) type I
GWAS
  • Estimated glomerular filtration rate ( 31152163)
Interacting Genes 3 interacting genes: LSM8 MFSD3 THTPA
Entrez ID 1798
HPRD ID 01879
Ensembl ID ENSG00000172269
Uniprot IDs A0A024R3H8 Q9H3H5
PDB IDs 5LEV 5O5E 6BW5 6BW6 6FM9 6FWZ
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025

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