Alzheimer - Wiki-Pi

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APP and CLIP4	amyloid beta (A4) precursor protein	CAP-GLY domain containing linker protein family, member 4	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation
APP and GPT2	amyloid beta (A4) precursor protein	glutamic pyruvate transaminase (alanine aminotransferase) 2	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation
APP and FERMT2	amyloid beta (A4) precursor protein	fermitin family member 2	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation	Cell junction organization Cell-extracellular matrix interactions
APP and LNX1	amyloid beta (A4) precursor protein	ligand of numb-protein X 1, E3 ubiquitin protein ligase	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation
APP and MAPRE2	amyloid beta (A4) precursor protein	microtubule-associated protein, RP/EB family, member 2	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation
APP and METAP2	amyloid beta (A4) precursor protein	methionyl aminopeptidase 2	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation	Inactivation, recovery and regulation of the phototransduction cascade Visual phototransduction The phototransduction cascade Diseases associated with visual transduction	L-Methionine 3,5,6,8-Tetramethyl-N-Methyl Phenanthrolinium Fumagillin D-Methionine N\'-(2s,3r)-3-Amino-4-Cyclohexyl-2-Hydroxy-Butano-N-(4-Methylphenyl)Hydrazide (E)-(2r,3r,4s,5r)-3,4,5-Trihydroxy-2-Methoxy-8,8-Dimethyl-Non-6-Enoic Acid ((3s,6r)-6-Hydroxy-2-Oxo-Azepan-3-Yl)-Amide 2-Methyl-2-Propanol (2s,3r)-3-Amino-2-Hydroxy-5-(Ethylsulfanyl)Pentanoyl-((S)-(-)-(1-Naphthyl)Ethyl)Amide Ovalicin 5-BROMO-2-{[(4-CHLOROPHENYL)SULFONYL]AMINO}BENZOIC ACID 5-METHYL-2-[(PHENYLSULFONYL)AMINO]BENZOIC ACID 2-[(PHENYLSULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID 2-[({2-[(1Z)-3-(DIMETHYLAMINO)PROP-1-ENYL]-4-FLUOROPHENYL}SULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID N\'-((2S,3R)-3-AMINO-2-HYDROXY-5-(ISOPROPYLSULFANYL)PENTANOYL)-N-3-CHLOROBENZOYL HYDRAZIDE 3-ETHYL-6-{[(4-FLUOROPHENYL)SULFONYL]AMINO}-2-METHYLBENZOIC ACID (CHLOROACETYL)CARBAMIC ACID (3R,4S,5S,5R)-5-METHOXY-4-[(2R,3R)-2-METHYL-3-(3-METHYL-2-BUTENYL)OXIRANYL]-1-OXASPIRO[2.5]OCT-6-YL ESTER
APP and GNRH2	amyloid beta (A4) precursor protein	gonadotropin-releasing hormone 2	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation	G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Hormone ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
APP and SF3B2	amyloid beta (A4) precursor protein	splicing factor 3b, subunit 2, 145kDa	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway
APP and PSRC1	amyloid beta (A4) precursor protein	proline/serine-rich coiled-coil 1	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation
APP and GOLGA4	amyloid beta (A4) precursor protein	golgin A4	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation
APP and PRRC2B	amyloid beta (A4) precursor protein	proline-rich coiled-coil 2B	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation
APP and SPSB2	amyloid beta (A4) precursor protein	splA/ryanodine receptor domain and SOCS box containing 2	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
APP and KIF2C	amyloid beta (A4) precursor protein	kinesin family member 2C	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation	Mitotic Prometaphase Separation of Sister Chromatids Kinesins Mitotic Anaphase Factors involved in megakaryocyte development and platelet production M Phase Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion MHC class II antigen presentation Mitotic Metaphase and Anaphase Adaptive Immune System
APP and CNDP1	amyloid beta (A4) precursor protein	carnosine dipeptidase 1 (metallopeptidase M20 family)	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation
APP and GPC1	amyloid beta (A4) precursor protein	glypican 1	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Axon guidance Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Inactivation of Cdc42 and Rac Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA Activation of Rac MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Role of Abl in Robo-Slit signaling Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS Diseases associated with visual transduction MPS IV - Morquio syndrome A Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates Signaling by Robo receptor HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome
APP and ANKRD13D	amyloid beta (A4) precursor protein	ankyrin repeat domain 13 family, member D	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation
APP and MARS2	amyloid beta (A4) precursor protein	methionyl-tRNA synthetase 2, mitochondrial	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation	tRNA Aminoacylation Mitochondrial tRNA aminoacylation
APP and RSPH10B2	amyloid beta (A4) precursor protein	radial spoke head 10 homolog B2 (Chlamydomonas)	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation
APP and GPR12	amyloid beta (A4) precursor protein	G protein-coupled receptor 12	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation
APP and HTRA2	amyloid beta (A4) precursor protein	HtrA serine peptidase 2	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation

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