PRKAA2 and TCF4 |
protein kinase, AMP-activated, alpha 2 catalytic subunit |
transcription factor 4 |
- Organelle biogenesis and maintenance
- Integration of energy metabolism
- Metabolism of lipids and lipoproteins
- Regulation of Rheb GTPase activity by AMPK
- IRS-mediated signalling
- mTOR signalling
- Translocation of GLUT4 to the plasma membrane
- Import of palmitoyl-CoA into the mitochondrial matrix
- mTOR signalling
- IGF1R signaling cascade
- IRS-related events triggered by IGF1R
- Energy dependent regulation of mTOR by LKB1-AMPK
- PKB-mediated events
- PI3K Cascade
- Signaling by Insulin receptor
- Fatty acid, triacylglycerol, and ketone body metabolism
- Insulin receptor signalling cascade
- Regulation of AMPK activity via LKB1
- IRS-related events
- Mitochondrial biogenesis
- IRS-mediated signalling
- Activation of PPARGC1A (PGC-1alpha) by phosphorylation
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- AMPK inhibits chREBP transcriptional activation activity
- PKB-mediated events
- PI3K Cascade
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- CDO in myogenesis
- Myogenesis
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PRKAB2 and TCF4 |
protein kinase, AMP-activated, beta 2 non-catalytic subunit |
transcription factor 4 |
- Organelle biogenesis and maintenance
- Integration of energy metabolism
- Metabolism of lipids and lipoproteins
- Regulation of Rheb GTPase activity by AMPK
- IRS-mediated signalling
- mTOR signalling
- Translocation of GLUT4 to the plasma membrane
- Import of palmitoyl-CoA into the mitochondrial matrix
- mTOR signalling
- IGF1R signaling cascade
- IRS-related events triggered by IGF1R
- Energy dependent regulation of mTOR by LKB1-AMPK
- PKB-mediated events
- PI3K Cascade
- Signaling by Insulin receptor
- Fatty acid, triacylglycerol, and ketone body metabolism
- Insulin receptor signalling cascade
- Regulation of AMPK activity via LKB1
- IRS-related events
- Mitochondrial biogenesis
- IRS-mediated signalling
- Activation of PPARGC1A (PGC-1alpha) by phosphorylation
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- AMPK inhibits chREBP transcriptional activation activity
- PKB-mediated events
- PI3K Cascade
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- CDO in myogenesis
- Myogenesis
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PRKCE and MAP4K4 |
protein kinase C, epsilon |
mitogen-activated protein kinase kinase kinase kinase 4 |
- G alpha (q) signalling events
- Signaling by GPCR
- Signaling by FGFR in disease
- Phospholipase C-mediated cascade
- Signaling by EGFRvIII in Cancer
- Effects of PIP2 hydrolysis
- PLCG1 events in ERBB2 signaling
- DAG and IP3 signaling
- DAP12 signaling
- Gastrin-CREB signalling pathway via PKC and MAPK
- Downstream signaling of activated FGFR
- G alpha (z) signalling events
- Role of phospholipids in phagocytosis
- Fcgamma receptor (FCGR) dependent phagocytosis
- Innate Immune System
- Signaling by PDGF
- DAP12 interactions
- Signalling by NGF
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- EGFR interacts with phospholipase C-gamma
- G alpha (q) signalling events
- Signaling by ERBB2
- Signaling by EGFR
- GPCR downstream signaling
- Downstream signal transduction
- PLC-gamma1 signalling
- Signaling by EGFR in Cancer
- Platelet activation, signaling and aggregation
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- Oxidative Stress Induced Senescence
- Cellular Senescence
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PRKCG and PARD3 |
protein kinase C, gamma |
par-3 family cell polarity regulator |
- Signaling by GPCR
- Ca-dependent events
- CaM pathway
- Phospholipase C-mediated cascade
- Signaling by FGFR in disease
- Signaling by Wnt
- Signaling by EGFRvIII in Cancer
- PLCG1 events in ERBB2 signaling
- DAP12 signaling
- Response to elevated platelet cytosolic Ca2+
- G alpha (z) signalling events
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Signaling by PDGF
- Calmodulin induced events
- DAP12 interactions
- Opioid Signalling
- EGFR interacts with phospholipase C-gamma
- Signaling by ERBB2
- Signaling by EGFR
- GPCR downstream signaling
- Downstream signal transduction
- Calmodulin induced events
- WNT5A-dependent internalization of FZD4
- Signaling by EGFR in Cancer
- Platelet activation, signaling and aggregation
- PCP/CE pathway
- Transmission across Chemical Synapses
- Trafficking of GluR2-containing AMPA receptors
- DAG and IP3 signaling
- CaM pathway
- Downstream signaling of activated FGFR
- Disinhibition of SNARE formation
- Innate Immune System
- Signalling by NGF
- PLC beta mediated events
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- G-protein mediated events
- NGF signalling via TRKA from the plasma membrane
- Trafficking of AMPA receptors
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- beta-catenin independent WNT signaling
- PLC-gamma1 signalling
- Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
|
- Loss of Function of TGFBR2 in Cancer
- Cell junction organization
- TGFBR2 MSI Frameshift Mutants in Cancer
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Tight junction interactions
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- TGFBR1 LBD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Cell-cell junction organization
- Signaling by TGF-beta Receptor Complex
- Signaling by TGF-beta Receptor Complex in Cancer
- SMAD4 MH2 Domain Mutants in Cancer
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PRKCI and PARD3 |
protein kinase C, iota |
par-3 family cell polarity regulator |
- Cell junction organization
- Cell-cell junction organization
- Signalling by NGF
- p75NTR recruits signalling complexes
- Tight junction interactions
- p75NTR signals via NF-kB
- p75 NTR receptor-mediated signalling
|
- Loss of Function of TGFBR2 in Cancer
- Cell junction organization
- TGFBR2 MSI Frameshift Mutants in Cancer
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Tight junction interactions
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- TGFBR1 LBD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Cell-cell junction organization
- Signaling by TGF-beta Receptor Complex
- Signaling by TGF-beta Receptor Complex in Cancer
- SMAD4 MH2 Domain Mutants in Cancer
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PRKCZ and FEZ1 |
protein kinase C, zeta |
fasciculation and elongation protein zeta 1 (zygin I) |
- Loss of Function of TGFBR2 in Cancer
- TGFBR2 MSI Frameshift Mutants in Cancer
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- TGFBR1 LBD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- VEGFA-VEGFR2 Pathway
- VEGFR2 mediated cell proliferation
- Signaling by TGF-beta Receptor Complex
- Signaling by TGF-beta Receptor Complex in Cancer
- Signaling by VEGF
- GPVI-mediated activation cascade
- Platelet activation, signaling and aggregation
- SMAD4 MH2 Domain Mutants in Cancer
|
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PRKDC and CTDP1 |
protein kinase, DNA-activated, catalytic polypeptide |
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 |
- Nonhomologous End-joining (NHEJ)
- Cytosolic sensors of pathogen-associated DNA
- Processing of DNA ends prior to end rejoining
- STING mediated induction of host immune responses
- Double-Strand Break Repair
- IRF3-mediated induction of type I IFN
- Innate Immune System
|
- Formation of HIV-1 elongation complex containing HIV-1 Tat
- RNA Polymerase II Transcription
- Abortive elongation of HIV-1 transcript in the absence of Tat
- HIV Infection
- Formation of the Early Elongation Complex
- Tat-mediated elongation of the HIV-1 transcript
- Tat-mediated HIV elongation arrest and recovery
- RNA Polymerase II Pre-transcription Events
- Late Phase of HIV Life Cycle
- Pausing and recovery of Tat-mediated HIV elongation
- Formation of RNA Pol II elongation complex
- HIV elongation arrest and recovery
- HIV Life Cycle
- Pausing and recovery of HIV elongation
- Formation of HIV elongation complex in the absence of HIV Tat
- Formation of the HIV-1 Early Elongation Complex
- HIV Transcription Elongation
- Transcription of the HIV genome
- RNA Polymerase II Transcription Elongation
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MAPK1 and HDAC4 |
mitogen-activated protein kinase 1 |
histone deacetylase 4 |
- phospho-PLA2 pathway
- Ca-dependent events
- Signaling by FGFR in disease
- Cellular Senescence
- ERKs are inactivated
- CREB phosphorylation through the activation of Ras
- Signaling by EGFRvIII in Cancer
- Toll Like Receptor TLR1:TLR2 Cascade
- Toll Like Receptor 5 (TLR5) Cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- MyD88 dependent cascade initiated on endosome
- SOS-mediated signalling
- Fcgamma receptor (FCGR) dependent phagocytosis
- SHC-mediated signalling
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Regulation of actin dynamics for phagocytic cup formation
- TRIF-mediated TLR3/TLR4 signaling
- Senescence-Associated Secretory Phenotype (SASP)
- Signaling by VEGF
- Signalling to RAS
- Downstream signal transduction
- Toll Like Receptor 3 (TLR3) Cascade
- Interleukin-2 signaling
- Platelet activation, signaling and aggregation
- Frs2-mediated activation
- Transmission across Chemical Synapses
- Axon guidance
- IRS-mediated signalling
- L1CAM interactions
- Oncogene Induced Senescence
- VEGFA-VEGFR2 Pathway
- Activated TLR4 signalling
- VEGFR2 mediated cell proliferation
- GRB2 events in ERBB2 signaling
- RSK activation
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88:Mal cascade initiated on plasma membrane
- NCAM signaling for neurite out-growth
- Signalling to p38 via RIT and RIN
- RAF/MAP kinase cascade
- Innate Immune System
- Signaling by Insulin receptor
- ERKs are inactivated
- Signal transduction by L1
- Insulin receptor signalling cascade
- PLC beta mediated events
- IRS-related events
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- SHC-related events
- G-protein mediated events
- Signaling by FGFR
- Thrombin signalling through proteinase activated receptors (PARs)
- ARMS-mediated activation
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Signal attenuation
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- ERK/MAPK targets
- MAPK targets/ Nuclear events mediated by MAP kinases
- Signaling by GPCR
- Mitotic Prophase
- Golgi Cisternae Pericentriolar Stack Reorganization
- FCERI mediated MAPK activation
- Signaling by SCF-KIT
- SHC1 events in ERBB2 signaling
- DAP12 signaling
- Toll Like Receptor 9 (TLR9) Cascade
- ERK/MAPK targets
- Negative regulation of FGFR signaling
- Signaling by PDGF
- DAP12 interactions
- Opioid Signalling
- SHC-related events triggered by IGF1R
- GRB2 events in EGFR signaling
- Signaling by ERBB4
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- SHC1 events in ERBB4 signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Signaling by Leptin
- Growth hormone receptor signaling
- Signalling to ERKs
- Prolonged ERK activation events
- ERK activation
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- IGF1R signaling cascade
- Recycling pathway of L1
- M Phase
- Toll Like Receptor TLR6:TLR2 Cascade
- IRS-related events triggered by IGF1R
- Activation of the AP-1 family of transcription factors
- MyD88 cascade initiated on plasma membrane
- ERK activation
- Downstream signaling of activated FGFR
- Advanced glycosylation endproduct receptor signaling
- Post NMDA receptor activation events
- Signalling by NGF
- SOS-mediated signalling
- MAP kinase activation in TLR cascade
- SHC-mediated signalling
- Cytokine Signaling in Immune system
- Cellular response to heat stress
- Regulation of HSF1-mediated heat shock response
- NGF signalling via TRKA from the plasma membrane
- MyD88-independent cascade
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Cell Cycle, Mitotic
- ERK2 activation
- SHC1 events in EGFR signaling
- FRS2-mediated cascade
- IRS-mediated signalling
- Oxidative Stress Induced Senescence
- ERK2 activation
- Nuclear Events (kinase and transcription factor activation)
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- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Signaling by NOTCH
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- NOTCH1 Intracellular Domain Regulates Transcription
- Signaling by NOTCH1
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
|
- Isoproterenol
- Arsenic trioxide
- Olomoucine
- Phosphonothreonine
- Purvalanol
- SB220025
- N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE
- N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE
- (S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE
- (3R,5Z,8S,9S,11E)-8,9,16-TRIHYDROXY-14-METHOXY-3-METHYL-3,4,9,10-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,7(8H)-DIONE
- 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE
- (1aR,8S,13S,14S,15aR)-5,13,14-trihydroxy-3-methoxy-8-methyl-8,9,13,14,15,15a-hexahydro-6H-oxireno[k][2]benzoxacyclotetradecine-6,12(1aH)-dione
- [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID
- 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE
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MAPK3 and HDAC4 |
mitogen-activated protein kinase 3 |
histone deacetylase 4 |
- Signaling by FGFR in disease
- RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
- Cellular Senescence
- ERKs are inactivated
- Signaling by EGFRvIII in Cancer
- Toll Like Receptor TLR1:TLR2 Cascade
- Toll Like Receptor 5 (TLR5) Cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- MyD88 dependent cascade initiated on endosome
- SOS-mediated signalling
- Fcgamma receptor (FCGR) dependent phagocytosis
- SHC-mediated signalling
- Regulation of actin dynamics for phagocytic cup formation
- TRIF-mediated TLR3/TLR4 signaling
- ERK1 activation
- Senescence-Associated Secretory Phenotype (SASP)
- ERK1 activation
- Signaling by VEGF
- Downstream signal transduction
- Toll Like Receptor 3 (TLR3) Cascade
- Signalling to RAS
- Interleukin-2 signaling
- Platelet activation, signaling and aggregation
- Frs2-mediated activation
- Axon guidance
- IRS-mediated signalling
- L1CAM interactions
- Oncogene Induced Senescence
- VEGFA-VEGFR2 Pathway
- Activated TLR4 signalling
- VEGFR2 mediated cell proliferation
- GRB2 events in ERBB2 signaling
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88:Mal cascade initiated on plasma membrane
- NCAM signaling for neurite out-growth
- RAF/MAP kinase cascade
- Signalling to p38 via RIT and RIN
- Innate Immune System
- Signaling by Insulin receptor
- ERKs are inactivated
- Signal transduction by L1
- Insulin receptor signalling cascade
- ISG15 antiviral mechanism
- Interferon Signaling
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- IRS-related events
- SHC-related events
- Signaling by FGFR
- Thrombin signalling through proteinase activated receptors (PARs)
- ARMS-mediated activation
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Signal attenuation
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- ERK/MAPK targets
- MAPK targets/ Nuclear events mediated by MAP kinases
- Signaling by GPCR
- FCERI mediated MAPK activation
- SHC1 events in ERBB2 signaling
- Signaling by SCF-KIT
- DAP12 signaling
- Toll Like Receptor 9 (TLR9) Cascade
- ERK/MAPK targets
- Negative regulation of FGFR signaling
- Signaling by PDGF
- DAP12 interactions
- SHC-related events triggered by IGF1R
- GRB2 events in EGFR signaling
- Signaling by ERBB4
- Antiviral mechanism by IFN-stimulated genes
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- SHC1 events in ERBB4 signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Growth hormone receptor signaling
- Signaling by Leptin
- Signalling to ERKs
- Prolonged ERK activation events
- ERK activation
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- RNA Polymerase I Promoter Clearance
- IGF1R signaling cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- IRS-related events triggered by IGF1R
- Activation of the AP-1 family of transcription factors
- MyD88 cascade initiated on plasma membrane
- ERK activation
- Downstream signaling of activated FGFR
- Advanced glycosylation endproduct receptor signaling
- Signalling by NGF
- SOS-mediated signalling
- MAP kinase activation in TLR cascade
- RNA Polymerase I Transcription
- SHC-mediated signalling
- Cytokine Signaling in Immune system
- Cellular response to heat stress
- Regulation of HSF1-mediated heat shock response
- NGF signalling via TRKA from the plasma membrane
- MyD88-independent cascade
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- SHC1 events in EGFR signaling
- FRS2-mediated cascade
- IRS-mediated signalling
- Oxidative Stress Induced Senescence
- RNA Polymerase I Promoter Opening
- Nuclear Events (kinase and transcription factor activation)
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- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Signaling by NOTCH
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- NOTCH1 Intracellular Domain Regulates Transcription
- Signaling by NOTCH1
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
|
- Sulindac
- Arsenic trioxide
- Purvalanol
- 5-iodotubercidin
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MAPK6 and BAG6 |
mitogen-activated protein kinase 6 |
BCL2-associated athanogene 6 |
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MAP2K1 and TRAF3 |
mitogen-activated protein kinase kinase 1 |
TNF receptor-associated factor 3 |
- Signaling by GPCR
- Signaling by FGFR in disease
- MEK activation
- FCERI mediated MAPK activation
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- SHC1 events in ERBB2 signaling
- Toll Like Receptor TLR1:TLR2 Cascade
- DAP12 signaling
- Uptake and actions of bacterial toxins
- Toll Like Receptor 5 (TLR5) Cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- SOS-mediated signalling
- Uptake and function of anthrax toxins
- SHC-mediated signalling
- Signaling by PDGF
- DAP12 interactions
- TRIF-mediated TLR3/TLR4 signaling
- ERK1 activation
- SHC-related events triggered by IGF1R
- GRB2 events in EGFR signaling
- ERK1 activation
- Signaling by ERBB4
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- SHC1 events in ERBB4 signaling
- Signaling by VEGF
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Signalling to RAS
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Interleukin-1 signaling
- Interleukin-2 signaling
- Frs2-mediated activation
- Signaling by Leptin
- Signalling to ERKs
- Prolonged ERK activation events
- ERK activation
- Axon guidance
- IRS-mediated signalling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- L1CAM interactions
- IGF1R signaling cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- VEGFA-VEGFR2 Pathway
- Activated TLR4 signalling
- IRS-related events triggered by IGF1R
- MyD88 cascade initiated on plasma membrane
- VEGFR2 mediated cell proliferation
- GRB2 events in ERBB2 signaling
- ERK activation
- RAF phosphorylates MEK
- Downstream signaling of activated FGFR
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88:Mal cascade initiated on plasma membrane
- NCAM signaling for neurite out-growth
- RAF/MAP kinase cascade
- Signalling to p38 via RIT and RIN
- Signaling by Insulin receptor
- Innate Immune System
- Signalling by NGF
- Signal transduction by L1
- Insulin receptor signalling cascade
- SOS-mediated signalling
- MAP kinase activation in TLR cascade
- SHC-mediated signalling
- Cytokine Signaling in Immune system
- IRS-related events
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- SHC-related events
- MyD88-independent cascade
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- ARMS-mediated activation
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- SHC1 events in EGFR signaling
- IRS-mediated signalling
- FRS2-mediated cascade
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
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- Activated TLR4 signalling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- TRAF3-dependent IRF activation pathway
- Toll-Like Receptors Cascades
- Negative regulators of RIG-I/MDA5 signaling
- TRIF-mediated TLR3/TLR4 signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- MyD88-independent cascade
- Innate Immune System
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
|
- K-252a
- 5-Bromo-N-(2,3-Dihydroxypropoxy)-3,4-Difluoro-2-[(2-Fluoro-4-Iodophenyl)Amino]Benzamide
- Bosutinib
- (5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamide
- 2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide
- N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
- N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine
- 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE
- Trametinib
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MAP2K7 and VRK2 |
mitogen-activated protein kinase kinase 7 |
vaccinia related kinase 2 |
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Cellular Senescence
- FCERI mediated MAPK activation
- Toll Like Receptor TLR6:TLR2 Cascade
- Toll Like Receptor TLR1:TLR2 Cascade
- Activated TLR4 signalling
- Uptake and actions of bacterial toxins
- MyD88 cascade initiated on plasma membrane
- Toll Like Receptor 5 (TLR5) Cascade
- MyD88 dependent cascade initiated on endosome
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Toll Like Receptor 9 (TLR9) Cascade
- Uptake and function of anthrax toxins
- Innate Immune System
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- TRIF-mediated TLR3/TLR4 signaling
- MAP kinase activation in TLR cascade
- MyD88-independent cascade
- Toll Like Receptor 2 (TLR2) Cascade
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Oxidative Stress Induced Senescence
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Fc epsilon receptor (FCERI) signaling
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PRNP and ZFYVE28 |
prion protein |
zinc finger, FYVE domain containing 28 |
- NCAM1 interactions
- Axon guidance
- NCAM signaling for neurite out-growth
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PRNP and ADAM23 |
prion protein |
ADAM metallopeptidase domain 23 |
- NCAM1 interactions
- Axon guidance
- NCAM signaling for neurite out-growth
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PRNP and BAG6 |
prion protein |
BCL2-associated athanogene 6 |
- NCAM1 interactions
- Axon guidance
- NCAM signaling for neurite out-growth
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PROX1 and RORA |
prospero homeobox 1 |
RAR-related orphan receptor A |
|
- PPARA activates gene expression
- Fatty acid, triacylglycerol, and ketone body metabolism
- Metabolism of lipids and lipoproteins
- Generic Transcription Pathway
- Nuclear Receptor transcription pathway
- Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
- REV-ERBA represses gene expression
- BMAL1:CLOCK,NPAS2 activates circadian gene expression
- RORA activates circadian gene expression
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RELN and VLDLR |
reelin |
very low density lipoprotein receptor |
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RELN and SQSTM1 |
reelin |
sequestosome 1 |
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- Signaling by Interleukins
- Signalling by NGF
- NF-kB is activated and signals survival
- p75NTR recruits signalling complexes
- Cell death signalling via NRAGE, NRIF and NADE
- NRIF signals cell death from the nucleus
- p75NTR signals via NF-kB
- Cytokine Signaling in Immune system
- Interleukin-1 signaling
- p75 NTR receptor-mediated signalling
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RELN and PCDHA4 |
reelin |
protocadherin alpha 4 |
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RELN and PCDHA6 |
reelin |
protocadherin alpha 6 |
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