Schizophrenia - Wiki-Pi

Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide
ROR2 and DAZAP2	receptor tyrosine kinase-like orphan receptor 2	DAZ associated protein 2	WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Signaling by Wnt PCP/CE pathway beta-catenin independent WNT signaling
ROR2 and WNT5A	receptor tyrosine kinase-like orphan receptor 2	wingless-type MMTV integration site family, member 5A	WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Signaling by Wnt PCP/CE pathway beta-catenin independent WNT signaling	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling negative regulation of TCF-dependent signaling by WNT ligand antagonists Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes WNT ligand biogenesis and trafficking beta-catenin independent WNT signaling WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Ca2+ pathway TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Asymmetric localization of PCP proteins WNT5A-dependent internalization of FZD4 XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer PCP/CE pathway Class B/2 (Secretin family receptors)
ROR2 and ZMYM4	receptor tyrosine kinase-like orphan receptor 2	zinc finger, MYM-type 4	WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Signaling by Wnt PCP/CE pathway beta-catenin independent WNT signaling
ROR2 and RBPMS	receptor tyrosine kinase-like orphan receptor 2	RNA binding protein with multiple splicing	WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Signaling by Wnt PCP/CE pathway beta-catenin independent WNT signaling
ROR2 and FZD5	receptor tyrosine kinase-like orphan receptor 2	frizzled class receptor 5	WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Signaling by Wnt PCP/CE pathway beta-catenin independent WNT signaling	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes beta-catenin independent WNT signaling disassembly of the destruction complex and recruitment of AXIN to the membrane WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Ca2+ pathway TCF dependent signaling in response to WNT regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation Asymmetric localization of PCP proteins XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer PCP/CE pathway Class B/2 (Secretin family receptors)
ROR2 and MAGED1	receptor tyrosine kinase-like orphan receptor 2	melanoma antigen family D, 1	WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Signaling by Wnt PCP/CE pathway beta-catenin independent WNT signaling	Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE NRAGE signals death through JNK Programmed Cell Death p75 NTR receptor-mediated signalling Role of DCC in regulating apoptosis Extrinsic Pathway
ROR2 and C1orf94	receptor tyrosine kinase-like orphan receptor 2	chromosome 1 open reading frame 94	WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Signaling by Wnt PCP/CE pathway beta-catenin independent WNT signaling
ROR2 and MAP3K7	receptor tyrosine kinase-like orphan receptor 2	mitogen-activated protein kinase kinase kinase 7	WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Signaling by Wnt PCP/CE pathway beta-catenin independent WNT signaling	Signaling by the B Cell Receptor (BCR) Downstream TCR signaling IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation TRAF6 mediated induction of TAK1 complex Toll Like Receptor 7/8 (TLR7/8) Cascade Signaling by Wnt Toll Like Receptor TLR6:TLR2 Cascade Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Innate Immune System IRAK2 mediated activation of TAK1 complex IRAK2 mediated activation of TAK1 complex MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling Cytokine Signaling in Immune system MyD88-independent cascade beta-catenin independent WNT signaling Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Ca2+ pathway Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Activation of NF-kappaB in B cells Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex
NR4A2 and SMARCA2	nuclear receptor subfamily 4, group A, member 2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Generic Transcription Pathway Nuclear Receptor transcription pathway	Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
TBC1D25 and FEZ1	TBC1 domain family, member 25	fasciculation and elongation protein zeta 1 (zygin I)
ORC4 and TCF4	origin recognition complex, subunit 4	transcription factor 4	G2/M Checkpoints Activation of the pre-replicative complex Activation of the pre-replicative complex Orc1 removal from chromatin Assembly of the pre-replicative complex Activation of ATR in response to replication stress G1/S Transition Assembly of the ORC complex at the origin of replication Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication Synthesis of DNA DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition S Phase CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Orc1 removal from chromatin E2F-enabled inhibition of pre-replication complex formation Cell Cycle Checkpoints Association of licensing factors with the pre-replicative complex CDT1 association with the CDC6:ORC:origin complex	CDO in myogenesis Myogenesis
P4HB and FEZ1	prolyl 4-hydroxylase, beta polypeptide	fasciculation and elongation protein zeta 1 (zygin I)	Lipoprotein metabolism Hedgehog ligand biogenesis Metabolism of lipids and lipoproteins Collagen formation Chylomicron-mediated lipid transport Processing-defective Hh variants abrogate ligand secretion Detoxification of Reactive Oxygen Species Lipid digestion, mobilization, and transport Signaling by Hedgehog Collagen biosynthesis and modifying enzymes
PAFAH1B1 and TNIK	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	TRAF2 and NCK interacting kinase	Mitotic Prometaphase Organelle biogenesis and maintenance Separation of Sister Chromatids Assembly of the primary cilium G2/M Transition Mitotic Anaphase Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane M Phase Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Resolution of Sister Chromatid Cohesion Loss of Nlp from mitotic centrosomes Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Recruitment of mitotic centrosome proteins and complexes	Oxidative Stress Induced Senescence Cellular Senescence
PAFAH1B1 and DISC1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	disrupted in schizophrenia 1	Mitotic Prometaphase Organelle biogenesis and maintenance Separation of Sister Chromatids Assembly of the primary cilium G2/M Transition Mitotic Anaphase Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane M Phase Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Resolution of Sister Chromatid Cohesion Loss of Nlp from mitotic centrosomes Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Recruitment of mitotic centrosome proteins and complexes
PARK2 and TCF4	parkin RBR E3 ubiquitin protein ligase	transcription factor 4	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	CDO in myogenesis Myogenesis
PAX3 and POU3F2	paired box 3	POU class 3 homeobox 2
PCNT and DISC1	pericentrin	disrupted in schizophrenia 1	Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
CDK16 and BAG6	cyclin-dependent kinase 16	BCL2-associated athanogene 6
PDE4B and DISC1	phosphodiesterase 4B, cAMP-specific	disrupted in schizophrenia 1	Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Opioid Signalling DARPP-32 events		Adenosine monophosphate Caffeine Theophylline Dyphylline Pentoxifylline Enprofylline Ketotifen Iloprost Papaverine Theobromine Amrinone (R)-Mesopram Roflumilast Piclamilast 4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]-2-Pyrrolidinone 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Filaminast 8-Bromo-Adenosine-5\'-Monophosphate (S)-Rolipram 1-(2-Chlorophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Cis-4-Cyano-4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]Cyclohexanecarboxylic Acid (R)-Rolipram S,S-(2-Hydroxyethyl)Thiocysteine Ibudilast 1-ethyl-N-(phenylmethyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid
PDZK1 and SLC17A1	PDZ domain containing 1	solute carrier family 17 (organic anion transporter), member 1		Organic anion transporters Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport

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