MEF2D and HDAC4 |
myocyte enhancer factor 2D |
histone deacetylase 4 |
- Organelle biogenesis and maintenance
- CDO in myogenesis
- Myogenesis
- Transcriptional activation of mitochondrial biogenesis
- Mitochondrial biogenesis
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- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Signaling by NOTCH
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- NOTCH1 Intracellular Domain Regulates Transcription
- Signaling by NOTCH1
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
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RAB8A and BAG6 |
RAB8A, member RAS oncogene family |
BCL2-associated athanogene 6 |
- Cargo trafficking to the periciliary membrane
- Organelle biogenesis and maintenance
- Translocation of GLUT4 to the plasma membrane
- VxPx cargo-targeting to cilium
- G2/M Transition
- Assembly of the primary cilium
- Mitotic G2-G2/M phases
- Regulation of PLK1 Activity at G2/M Transition
- Anchoring of the basal body to the plasma membrane
- Cell Cycle, Mitotic
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MEN1 and TCF4 |
multiple endocrine neoplasia I |
transcription factor 4 |
- Loss of Function of TGFBR2 in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- Signaling by Wnt
- TGFBR1 LBD Mutants in Cancer
- deactivation of the beta-catenin transactivating complex
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- Generic Transcription Pathway
- RNF mutants show enhanced WNT signaling and proliferation
- XAV939 inhibits tankyrase, stabilizing AXIN
- TGFBR2 MSI Frameshift Mutants in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- formation of the beta-catenin:TCF transactivating complex
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Signaling by TGF-beta Receptor Complex
- Signaling by TGF-beta Receptor Complex in Cancer
- TCF dependent signaling in response to WNT
- Signaling by WNT in cancer
- SMAD4 MH2 Domain Mutants in Cancer
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- CDO in myogenesis
- Myogenesis
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MEN1 and NFKB1 |
multiple endocrine neoplasia I |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
- Loss of Function of TGFBR2 in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- Signaling by Wnt
- TGFBR1 LBD Mutants in Cancer
- deactivation of the beta-catenin transactivating complex
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- Generic Transcription Pathway
- RNF mutants show enhanced WNT signaling and proliferation
- XAV939 inhibits tankyrase, stabilizing AXIN
- TGFBR2 MSI Frameshift Mutants in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- formation of the beta-catenin:TCF transactivating complex
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Signaling by TGF-beta Receptor Complex
- Signaling by TGF-beta Receptor Complex in Cancer
- TCF dependent signaling in response to WNT
- Signaling by WNT in cancer
- SMAD4 MH2 Domain Mutants in Cancer
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- Signaling by the B Cell Receptor (BCR)
- NF-kB is activated and signals survival
- Downstream TCR signaling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Cellular Senescence
- RIP-mediated NFkB activation via ZBP1
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- Toll Like Receptor TLR1:TLR2 Cascade
- Downstream signaling events of B Cell Receptor (BCR)
- FCERI mediated NF-kB activation
- MyD88 cascade initiated on plasma membrane
- Toll Like Receptor 5 (TLR5) Cascade
- ZBP1(DAI) mediated induction of type I IFNs
- p75NTR signals via NF-kB
- Transcriptional regulation of white adipocyte differentiation
- MyD88 dependent cascade initiated on endosome
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88:Mal cascade initiated on plasma membrane
- Toll Like Receptor 9 (TLR9) Cascade
- Innate Immune System
- Regulated proteolysis of p75NTR
- Signalling by NGF
- TRIF-mediated TLR3/TLR4 signaling
- Cytosolic sensors of pathogen-associated DNA
- Senescence-Associated Secretory Phenotype (SASP)
- Cytokine Signaling in Immune system
- p75 NTR receptor-mediated signalling
- MyD88-independent cascade
- Toll Like Receptor 2 (TLR2) Cascade
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Signaling by Interleukins
- TCR signaling
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Interleukin-1 processing
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Activation of NF-kappaB in B cells
- Fc epsilon receptor (FCERI) signaling
- TRAF6 mediated NF-kB activation
- Interleukin-1 signaling
- Adaptive Immune System
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
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- Thalidomide
- Pranlukast
- Triflusal
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MEOX2 and NALCN |
mesenchyme homeobox 2 |
sodium leak channel, non selective |
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- Ion channel transport
- Stimuli-sensing channels
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MEOX2 and CNTNAP2 |
mesenchyme homeobox 2 |
contactin associated protein-like 2 |
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MEST and FEZ1 |
mesoderm specific transcript |
fasciculation and elongation protein zeta 1 (zygin I) |
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MEST and BAG6 |
mesoderm specific transcript |
BCL2-associated athanogene 6 |
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MFAP1 and MAD1L1 |
microfibrillar-associated protein 1 |
MAD1 mitotic arrest deficient-like 1 (yeast) |
- Molecules associated with elastic fibres
- Elastic fibre formation
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- Mitotic Spindle Checkpoint
- Amplification of signal from the kinetochores
- Mitotic Prometaphase
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- Cell Cycle Checkpoints
- Mitotic Anaphase
- Mitotic Metaphase and Anaphase
- Cell Cycle, Mitotic
- M Phase
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CIITA and HDAC4 |
class II, major histocompatibility complex, transactivator |
histone deacetylase 4 |
- Interferon gamma signaling
- Interferon Signaling
- Cytokine Signaling in Immune system
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- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Signaling by NOTCH
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- NOTCH1 Intracellular Domain Regulates Transcription
- Signaling by NOTCH1
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
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MLLT6 and TCF4 |
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 |
transcription factor 4 |
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- CDO in myogenesis
- Myogenesis
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MLLT6 and WHSC1L1 |
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 |
Wolf-Hirschhorn syndrome candidate 1-like 1 |
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- Chromatin modifying enzymes
- Chromatin organization
- PKMTs methylate histone lysines
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MMP2 and CXCL12 |
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) |
chemokine (C-X-C motif) ligand 12 |
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- EPH-ephrin mediated repulsion of cells
- Axon guidance
- Collagen degradation
- Activation of Matrix Metalloproteinases
- EPH-Ephrin signaling
- Degradation of the extracellular matrix
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- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- Class A/1 (Rhodopsin-like receptors)
- Signaling by ERBB4
- GPCR ligand binding
- Metabolic disorders of biological oxidation enzymes
- GPCR downstream signaling
- Nuclear signaling by ERBB4
- Peptide ligand-binding receptors
- Chemokine receptors bind chemokines
- G alpha (i) signalling events
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- Marimastat
- Captopril
- SC-74020
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MNAT1 and TRIM26 |
MNAT CDK-activating kinase assembly factor 1 |
tripartite motif containing 26 |
- RNA Polymerase II Promoter Escape
- Formation of HIV-1 elongation complex containing HIV-1 Tat
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
- RNA Polymerase I Chain Elongation
- RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
- Tat-mediated elongation of the HIV-1 transcript
- Cyclin E associated events during G1/S transition
- Formation of transcription-coupled NER (TC-NER) repair complex
- Dual incision reaction in TC-NER
- NoRC negatively regulates rRNA expression
- G1/S Transition
- Mitotic G1-G1/S phases
- S Phase
- Late Phase of HIV Life Cycle
- Formation of RNA Pol II elongation complex
- Global Genomic NER (GG-NER)
- RNA Polymerase II Transcription Initiation And Promoter Clearance
- Cyclin A:Cdk2-associated events at S phase entry
- Mitotic G2-G2/M phases
- Transcription of the HIV genome
- Nucleotide Excision Repair
- RNA Polymerase II Transcription
- RNA Polymerase I Transcription Initiation
- HIV Infection
- RNA Polymerase I Promoter Clearance
- Formation of the Early Elongation Complex
- G2/M Transition
- RNA Pol II CTD phosphorylation and interaction with CE
- RNA Polymerase II Pre-transcription Events
- HIV Transcription Initiation
- HIV Life Cycle
- RNA Pol II CTD phosphorylation and interaction with CE
- Cyclin A/B1 associated events during G2/M transition
- RNA Polymerase II HIV Promoter Escape
- HIV Transcription Elongation
- Dual incision reaction in GG-NER
- RNA Polymerase I Transcription
- mRNA Capping
- RNA Polymerase I Promoter Escape
- RNA Polymerase I Transcription Termination
- G1 Phase
- Epigenetic regulation of gene expression
- Negative epigenetic regulation of rRNA expression
- Cell Cycle, Mitotic
- Cyclin D associated events in G1
- Transcription-coupled NER (TC-NER)
- Formation of HIV elongation complex in the absence of HIV Tat
- Formation of the HIV-1 Early Elongation Complex
- Formation of incision complex in GG-NER
- RNA Polymerase II Transcription Initiation
- RNA Polymerase II Transcription Elongation
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- Interferon gamma signaling
- Interferon Signaling
- Cytokine Signaling in Immune system
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MNDA and WHSC1L1 |
myeloid cell nuclear differentiation antigen |
Wolf-Hirschhorn syndrome candidate 1-like 1 |
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- Chromatin modifying enzymes
- Chromatin organization
- PKMTs methylate histone lysines
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ABCC1 and TRAF3 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
TNF receptor-associated factor 3 |
- Metabolism of vitamins and cofactors
- Defective CD320 causes methylmalonic aciduria
- Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
- ABC-family proteins mediated transport
- Metabolism of lipids and lipoproteins
- Defective BTD causes biotidinase deficiency
- Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
- Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
- Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
- Arachidonic acid metabolism
- Defective AMN causes hereditary megaloblastic anemia 1
- Defects in cobalamin (B12) metabolism
- Defective GIF causes intrinsic factor deficiency
- Defective HLCS causes multiple carboxylase deficiency
- Defective MMAB causes methylmalonic aciduria type cblB
- Synthesis of Leukotrienes (LT) and Eoxins (EX)
- Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
- Defective MMAA causes methylmalonic aciduria type cblA
- Defective CUBN causes hereditary megaloblastic anemia 1
- Cobalamin (Cbl, vitamin B12) transport and metabolism
- Defective MUT causes methylmalonic aciduria mut type
- Metabolism of water-soluble vitamins and cofactors
- Defects in biotin (Btn) metabolism
- Defective TCN2 causes hereditary megaloblastic anemia
- Defects in vitamin and cofactor metabolism
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- Activated TLR4 signalling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- TRAF3-dependent IRF activation pathway
- Toll-Like Receptors Cascades
- Negative regulators of RIG-I/MDA5 signaling
- TRIF-mediated TLR3/TLR4 signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- MyD88-independent cascade
- Innate Immune System
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
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TRIM37 and TRAF3 |
tripartite motif containing 37 |
TNF receptor-associated factor 3 |
- Antigen processing: Ubiquitination & Proteasome degradation
- Class I MHC mediated antigen processing & presentation
- Adaptive Immune System
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- Activated TLR4 signalling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- TRAF3-dependent IRF activation pathway
- Toll-Like Receptors Cascades
- Negative regulators of RIG-I/MDA5 signaling
- TRIF-mediated TLR3/TLR4 signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- MyD88-independent cascade
- Innate Immune System
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
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MUSK and SYNE1 |
muscle, skeletal, receptor tyrosine kinase |
spectrin repeat containing, nuclear envelope 1 |
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MYB and SMARCA2 |
v-myb avian myeloblastosis viral oncogene homolog |
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 |
- Factors involved in megakaryocyte development and platelet production
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- Chromatin modifying enzymes
- Chromatin organization
- RMTs methylate histone arginines
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MYB and ERC2 |
v-myb avian myeloblastosis viral oncogene homolog |
ELKS/RAB6-interacting/CAST family member 2 |
- Factors involved in megakaryocyte development and platelet production
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