KPNA4 and PLAA |
karyopherin alpha 4 (importin alpha 3) |
phospholipase A2-activating protein |
- ISG15 antiviral mechanism
- Interferon Signaling
- Cytokine Signaling in Immune system
- Antiviral mechanism by IFN-stimulated genes
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KRT31 and HDAC4 |
keratin 31, type I |
histone deacetylase 4 |
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- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Signaling by NOTCH
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- NOTCH1 Intracellular Domain Regulates Transcription
- Signaling by NOTCH1
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
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L1CAM and NRP1 |
L1 cell adhesion molecule |
neuropilin 1 |
- Interaction between L1 and Ankyrins
- Signal transduction by L1
- Axon guidance
- L1CAM interactions
- Recycling pathway of L1
- Basigin interactions
- Cell surface interactions at the vascular wall
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- Signal transduction by L1
- CHL1 interactions
- Axon guidance
- Semaphorin interactions
- Signaling by VEGF
- Sema3A PAK dependent Axon repulsion
- Neurophilin interactions with VEGF and VEGFR
- L1CAM interactions
- SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
- CRMPs in Sema3A signaling
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LASP1 and TCF4 |
LIM and SH3 protein 1 |
transcription factor 4 |
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- CDO in myogenesis
- Myogenesis
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LBP and BAG6 |
lipopolysaccharide binding protein |
BCL2-associated athanogene 6 |
- Toll-Like Receptors Cascades
- Toll Like Receptor 4 (TLR4) Cascade
- Transfer of LPS from LBP carrier to CD14
- Innate Immune System
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LIMK2 and PARD3 |
LIM domain kinase 2 |
par-3 family cell polarity regulator |
- EPHB-mediated forward signaling
- Axon guidance
- Semaphorin interactions
- EPH-Ephrin signaling
- Sema4D in semaphorin signaling
- Sema4D induced cell migration and growth-cone collapse
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- Loss of Function of TGFBR2 in Cancer
- Cell junction organization
- TGFBR2 MSI Frameshift Mutants in Cancer
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Tight junction interactions
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- TGFBR1 LBD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Cell-cell junction organization
- Signaling by TGF-beta Receptor Complex
- Signaling by TGF-beta Receptor Complex in Cancer
- SMAD4 MH2 Domain Mutants in Cancer
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LMNA and SYNE1 |
lamin A/C |
spectrin repeat containing, nuclear envelope 1 |
- IRE1alpha activates chaperones
- XBP1(S) activates chaperone genes
- Unfolded Protein Response (UPR)
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LMO1 and TCF4 |
LIM domain only 1 (rhombotin 1) |
transcription factor 4 |
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- CDO in myogenesis
- Myogenesis
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LNPEP and TCF4 |
leucyl/cystinyl aminopeptidase |
transcription factor 4 |
- Antigen processing: Ubiquitination & Proteasome degradation
- Translocation of GLUT4 to the plasma membrane
- Endosomal/Vacuolar pathway
- Class I MHC mediated antigen processing & presentation
- Antigen processing-Cross presentation
- Adaptive Immune System
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- CDO in myogenesis
- Myogenesis
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LOX and HIST1H2BJ |
lysyl oxidase |
histone cluster 1, H2bj |
- Collagen formation
- Crosslinking of collagen fibrils
- Elastic fibre formation
- Assembly of collagen fibrils and other multimeric structures
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- RNA Polymerase I Chain Elongation
- RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
- Mitotic Prophase
- Regulatory RNA pathways
- RNA Polymerase I Promoter Clearance
- Deposition of new CENPA-containing nucleosomes at the centromere
- Cellular Senescence
- Signaling by Wnt
- HATs acetylate histones
- M Phase
- Amyloids
- NoRC negatively regulates rRNA expression
- Packaging Of Telomere Ends
- Telomere Maintenance
- Nucleosome assembly
- RNF mutants show enhanced WNT signaling and proliferation
- XAV939 inhibits tankyrase, stabilizing AXIN
- DNA methylation
- Transcriptional regulation by small RNAs
- Meiotic recombination
- DNA Damage/Telomere Stress Induced Senescence
- Chromosome Maintenance
- Chromatin organization
- HDACs deacetylate histones
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- RNA Polymerase I Transcription
- formation of the beta-catenin:TCF transactivating complex
- Meiotic synapsis
- Epigenetic regulation of gene expression
- Senescence-Associated Secretory Phenotype (SASP)
- Negative epigenetic regulation of rRNA expression
- PRC2 methylates histones and DNA
- Cell Cycle, Mitotic
- Chromatin modifying enzymes
- Oxidative Stress Induced Senescence
- TCF dependent signaling in response to WNT
- RNA Polymerase I Promoter Opening
- SIRT1 negatively regulates rRNA Expression
- Signaling by WNT in cancer
- Condensation of Prophase Chromosomes
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LRP1 and ANKS1B |
low density lipoprotein receptor-related protein 1 |
ankyrin repeat and sterile alpha motif domain containing 1B |
- Scavenging of heme from plasma
- Visual phototransduction
- Diseases associated with visual transduction
- Retinoid metabolism and transport
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LRP1 and MMP16 |
low density lipoprotein receptor-related protein 1 |
matrix metallopeptidase 16 (membrane-inserted) |
- Scavenging of heme from plasma
- Visual phototransduction
- Diseases associated with visual transduction
- Retinoid metabolism and transport
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- Activation of Matrix Metalloproteinases
- Degradation of the extracellular matrix
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LRP2 and ANKS1B |
low density lipoprotein receptor-related protein 2 |
ankyrin repeat and sterile alpha motif domain containing 1B |
- Metabolism of lipids and lipoproteins
- Visual phototransduction
- Diseases associated with visual transduction
- Metabolism of steroid hormones and vitamin D
- Vitamin D (calciferol) metabolism
- Retinoid metabolism and transport
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- Urokinase
- Insulin Regular
- Insulin, porcine
- Gentamicin
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LTBR and TRAF3 |
lymphotoxin beta receptor (TNFR superfamily, member 3) |
TNF receptor-associated factor 3 |
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- Activated TLR4 signalling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- TRAF3-dependent IRF activation pathway
- Toll-Like Receptors Cascades
- Negative regulators of RIG-I/MDA5 signaling
- TRIF-mediated TLR3/TLR4 signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- MyD88-independent cascade
- Innate Immune System
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
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LYL1 and TCF4 |
lymphoblastic leukemia associated hematopoiesis regulator 1 |
transcription factor 4 |
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- CDO in myogenesis
- Myogenesis
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LYL1 and NFKB1 |
lymphoblastic leukemia associated hematopoiesis regulator 1 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
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- Signaling by the B Cell Receptor (BCR)
- NF-kB is activated and signals survival
- Downstream TCR signaling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Cellular Senescence
- RIP-mediated NFkB activation via ZBP1
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- Toll Like Receptor TLR1:TLR2 Cascade
- Downstream signaling events of B Cell Receptor (BCR)
- FCERI mediated NF-kB activation
- MyD88 cascade initiated on plasma membrane
- Toll Like Receptor 5 (TLR5) Cascade
- ZBP1(DAI) mediated induction of type I IFNs
- p75NTR signals via NF-kB
- Transcriptional regulation of white adipocyte differentiation
- MyD88 dependent cascade initiated on endosome
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88:Mal cascade initiated on plasma membrane
- Toll Like Receptor 9 (TLR9) Cascade
- Innate Immune System
- Regulated proteolysis of p75NTR
- Signalling by NGF
- TRIF-mediated TLR3/TLR4 signaling
- Cytosolic sensors of pathogen-associated DNA
- Senescence-Associated Secretory Phenotype (SASP)
- Cytokine Signaling in Immune system
- p75 NTR receptor-mediated signalling
- MyD88-independent cascade
- Toll Like Receptor 2 (TLR2) Cascade
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Signaling by Interleukins
- TCR signaling
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Interleukin-1 processing
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Activation of NF-kappaB in B cells
- Fc epsilon receptor (FCERI) signaling
- TRAF6 mediated NF-kB activation
- Interleukin-1 signaling
- Adaptive Immune System
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
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- Thalidomide
- Pranlukast
- Triflusal
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LYN and BANK1 |
LYN proto-oncogene, Src family tyrosine kinase |
B-cell scaffold protein with ankyrin repeats 1 |
- Signaling by the B Cell Receptor (BCR)
- Platelet Adhesion to exposed collagen
- Axon guidance
- Costimulation by the CD28 family
- FCERI mediated MAPK activation
- Signaling by SCF-KIT
- EPHB-mediated forward signaling
- EPHA-mediated growth cone collapse
- Regulation of KIT signaling
- FCERI mediated NF-kB activation
- EPH-ephrin mediated repulsion of cells
- Regulation of signaling by CBL
- EPH-Ephrin signaling
- Fcgamma receptor (FCGR) dependent phagocytosis
- FCGR activation
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- Innate Immune System
- CD28 co-stimulation
- CTLA4 inhibitory signaling
- Cytokine Signaling in Immune system
- Role of LAT2/NTAL/LAB on calcium mobilization
- Cell surface interactions at the vascular wall
- PECAM1 interactions
- Signaling by Interleukins
- Fc epsilon receptor (FCERI) signaling
- GPVI-mediated activation cascade
- FCERI mediated Ca+2 mobilization
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
- Adaptive Immune System
- Growth hormone receptor signaling
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SH2D1A and SLAMF1 |
SH2 domain containing 1A |
signaling lymphocytic activation molecule family member 1 |
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NBR1 and FEZ1 |
neighbor of BRCA1 gene 1 |
fasciculation and elongation protein zeta 1 (zygin I) |
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MAD2L1 and MAD1L1 |
MAD2 mitotic arrest deficient-like 1 (yeast) |
MAD1 mitotic arrest deficient-like 1 (yeast) |
- Amplification of signal from the kinetochores
- Mitotic Prometaphase
- Separation of Sister Chromatids
- Inactivation of APC/C via direct inhibition of the APC/C complex
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- APC/C:Cdc20 mediated degradation of mitotic proteins
- Mitotic Anaphase
- Regulation of APC/C activators between G1/S and early anaphase
- Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
- M Phase
- APC/C-mediated degradation of cell cycle proteins
- Cell Cycle, Mitotic
- Inactivation of APC/C via direct inhibition of the APC/C complex
- Mitotic Spindle Checkpoint
- Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
- Resolution of Sister Chromatid Cohesion
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- Regulation of mitotic cell cycle
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- Cell Cycle Checkpoints
- Mitotic Metaphase and Anaphase
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- Mitotic Spindle Checkpoint
- Amplification of signal from the kinetochores
- Mitotic Prometaphase
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- Cell Cycle Checkpoints
- Mitotic Anaphase
- Mitotic Metaphase and Anaphase
- Cell Cycle, Mitotic
- M Phase
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