IL3RA and JAK2 |
interleukin 3 receptor, alpha (low affinity) |
Janus kinase 2 |
- Signaling by GPCR
- G-protein beta:gamma signalling
- Cytokine Signaling in Immune system
- GPCR downstream signaling
- Signaling by Interleukins
- Interleukin receptor SHC signaling
- G beta:gamma signalling through PI3Kgamma
- Interleukin receptor SHC signaling
- GPVI-mediated activation cascade
- Interleukin-2 signaling
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
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- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Interferon gamma signaling
- Toll Like Receptor TLR1:TLR2 Cascade
- Toll Like Receptor 5 (TLR5) Cascade
- Interleukin receptor SHC signaling
- Gastrin-CREB signalling pathway via PKC and MAPK
- MyD88 dependent cascade initiated on endosome
- SOS-mediated signalling
- Prolactin receptor signaling
- SHC-mediated signalling
- TRIF-mediated TLR3/TLR4 signaling
- ERK1 activation
- ERK1 activation
- GPCR downstream signaling
- Signaling by VEGF
- Downstream signal transduction
- Toll Like Receptor 3 (TLR3) Cascade
- Signalling to RAS
- Interleukin-2 signaling
- Platelet activation, signaling and aggregation
- Frs2-mediated activation
- Axon guidance
- IRS-mediated signalling
- Interleukin-6 signaling
- VEGFA-VEGFR2 Pathway
- Activated TLR4 signalling
- VEGFR2 mediated cell proliferation
- GRB2 events in ERBB2 signaling
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- NCAM signaling for neurite out-growth
- RAF/MAP kinase cascade
- Signalling to p38 via RIT and RIN
- Innate Immune System
- Signaling by Insulin receptor
- Insulin receptor signalling cascade
- Interferon Signaling
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- IRS-related events
- SHC-related events
- RMTs methylate histone arginines
- Signaling by FGFR
- ARMS-mediated activation
- Toll-Like Receptors Cascades
- Nuclear signaling by ERBB4
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Interleukin receptor SHC signaling
- GPVI-mediated activation cascade
- Signaling by GPCR
- FCERI mediated MAPK activation
- SHC1 events in ERBB2 signaling
- Signaling by SCF-KIT
- DAP12 signaling
- Toll Like Receptor 9 (TLR9) Cascade
- Signaling by PDGF
- DAP12 interactions
- G-protein beta:gamma signalling
- Chromatin organization
- GRB2 events in EGFR signaling
- SHC-related events triggered by IGF1R
- Factors involved in megakaryocyte development and platelet production
- Signaling by ERBB4
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- Chromatin modifying enzymes
- SHC1 events in ERBB4 signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- Interleukin-3, 5 and GM-CSF signaling
- Growth hormone receptor signaling
- Signaling by Leptin
- Signalling to ERKs
- Prolonged ERK activation events
- ERK activation
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- IGF1R signaling cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- IRS-related events triggered by IGF1R
- MyD88 cascade initiated on plasma membrane
- ERK activation
- G beta:gamma signalling through PI3Kgamma
- Downstream signaling of activated FGFR
- Signalling by NGF
- SOS-mediated signalling
- MAP kinase activation in TLR cascade
- SHC-mediated signalling
- Cytokine Signaling in Immune system
- NGF signalling via TRKA from the plasma membrane
- MyD88-independent cascade
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- ERK2 activation
- SHC1 events in EGFR signaling
- FRS2-mediated cascade
- IRS-mediated signalling
- ERK2 activation
- Regulation of IFNG signaling
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IL3RA and SAE1 |
interleukin 3 receptor, alpha (low affinity) |
SUMO1 activating enzyme subunit 1 |
- Signaling by GPCR
- G-protein beta:gamma signalling
- Cytokine Signaling in Immune system
- GPCR downstream signaling
- Signaling by Interleukins
- Interleukin receptor SHC signaling
- G beta:gamma signalling through PI3Kgamma
- Interleukin receptor SHC signaling
- GPVI-mediated activation cascade
- Interleukin-2 signaling
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
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- Post-translational protein modification
- SUMOylation
- SUMO is conjugated to E1 (UBA2:SAE1)
- Processing and activation of SUMO
- SUMO is transferred from E1 to E2 (UBE2I, UBC9)
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IL3RA and FOXP1 |
interleukin 3 receptor, alpha (low affinity) |
forkhead box P1 |
- Signaling by GPCR
- G-protein beta:gamma signalling
- Cytokine Signaling in Immune system
- GPCR downstream signaling
- Signaling by Interleukins
- Interleukin receptor SHC signaling
- G beta:gamma signalling through PI3Kgamma
- Interleukin receptor SHC signaling
- GPVI-mediated activation cascade
- Interleukin-2 signaling
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
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IL3RA and NR0B2 |
interleukin 3 receptor, alpha (low affinity) |
nuclear receptor subfamily 0, group B, member 2 |
- Signaling by GPCR
- G-protein beta:gamma signalling
- Cytokine Signaling in Immune system
- GPCR downstream signaling
- Signaling by Interleukins
- Interleukin receptor SHC signaling
- G beta:gamma signalling through PI3Kgamma
- Interleukin receptor SHC signaling
- GPVI-mediated activation cascade
- Interleukin-2 signaling
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
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- Generic Transcription Pathway
- Nuclear Receptor transcription pathway
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IL3RA and JAK1 |
interleukin 3 receptor, alpha (low affinity) |
Janus kinase 1 |
- Signaling by GPCR
- G-protein beta:gamma signalling
- Cytokine Signaling in Immune system
- GPCR downstream signaling
- Signaling by Interleukins
- Interleukin receptor SHC signaling
- G beta:gamma signalling through PI3Kgamma
- Interleukin receptor SHC signaling
- GPVI-mediated activation cascade
- Interleukin-2 signaling
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
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- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Interferon gamma signaling
- Toll Like Receptor TLR1:TLR2 Cascade
- Toll Like Receptor 5 (TLR5) Cascade
- Interleukin receptor SHC signaling
- Gastrin-CREB signalling pathway via PKC and MAPK
- MyD88 dependent cascade initiated on endosome
- Interleukin-7 signaling
- SOS-mediated signalling
- SHC-mediated signalling
- TRIF-mediated TLR3/TLR4 signaling
- ERK1 activation
- ERK1 activation
- GPCR downstream signaling
- Signaling by VEGF
- Toll Like Receptor 3 (TLR3) Cascade
- Signalling to RAS
- Downstream signal transduction
- Interleukin-2 signaling
- Platelet activation, signaling and aggregation
- Frs2-mediated activation
- Axon guidance
- IRS-mediated signalling
- Interleukin-6 signaling
- VEGFA-VEGFR2 Pathway
- Activated TLR4 signalling
- VEGFR2 mediated cell proliferation
- GRB2 events in ERBB2 signaling
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- NCAM signaling for neurite out-growth
- RAF/MAP kinase cascade
- Signalling to p38 via RIT and RIN
- Innate Immune System
- Signaling by Insulin receptor
- Insulin receptor signalling cascade
- ISG15 antiviral mechanism
- Interferon Signaling
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- IRS-related events
- SHC-related events
- Signaling by FGFR
- ARMS-mediated activation
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Interleukin receptor SHC signaling
- GPVI-mediated activation cascade
- Signaling by GPCR
- FCERI mediated MAPK activation
- SHC1 events in ERBB2 signaling
- Signaling by SCF-KIT
- DAP12 signaling
- Toll Like Receptor 9 (TLR9) Cascade
- Signaling by PDGF
- DAP12 interactions
- Regulation of IFNA signaling
- G-protein beta:gamma signalling
- GRB2 events in EGFR signaling
- SHC-related events triggered by IGF1R
- Signaling by ERBB4
- Antiviral mechanism by IFN-stimulated genes
- Signaling by ERBB2
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by EGFR
- Signaling by Interleukins
- SHC1 events in ERBB4 signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- Interleukin-3, 5 and GM-CSF signaling
- Signaling by Leptin
- Signalling to ERKs
- Prolonged ERK activation events
- ERK activation
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- IGF1R signaling cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- IRS-related events triggered by IGF1R
- MyD88 cascade initiated on plasma membrane
- ERK activation
- G beta:gamma signalling through PI3Kgamma
- Downstream signaling of activated FGFR
- Interferon alpha/beta signaling
- Signalling by NGF
- SOS-mediated signalling
- MAP kinase activation in TLR cascade
- SHC-mediated signalling
- Cytokine Signaling in Immune system
- NGF signalling via TRKA from the plasma membrane
- MyD88-independent cascade
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- ERK2 activation
- SHC1 events in EGFR signaling
- FRS2-mediated cascade
- IRS-mediated signalling
- ERK2 activation
- Regulation of IFNG signaling
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IL3RA and PPP1CC |
interleukin 3 receptor, alpha (low affinity) |
protein phosphatase 1, catalytic subunit, gamma isozyme |
- Signaling by GPCR
- G-protein beta:gamma signalling
- Cytokine Signaling in Immune system
- GPCR downstream signaling
- Signaling by Interleukins
- Interleukin receptor SHC signaling
- G beta:gamma signalling through PI3Kgamma
- Interleukin receptor SHC signaling
- GPVI-mediated activation cascade
- Interleukin-2 signaling
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
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- Loss of Function of TGFBR2 in Cancer
- Mitotic Prometaphase
- Metabolism of lipids and lipoproteins
- Separation of Sister Chromatids
- Downregulation of TGF-beta receptor signaling
- SMAD2/3 MH2 Domain Mutants in Cancer
- TGF-beta receptor signaling activates SMADs
- Mitotic Anaphase
- TGFBR1 LBD Mutants in Cancer
- M Phase
- Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
- TGFBR2 MSI Frameshift Mutants in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- Lipid digestion, mobilization, and transport
- Cell Cycle, Mitotic
- Loss of Function of TGFBR1 in Cancer
- Signaling by TGF-beta Receptor Complex in Cancer
- Signaling by TGF-beta Receptor Complex
- Resolution of Sister Chromatid Cohesion
- Mitotic Metaphase and Anaphase
- SMAD4 MH2 Domain Mutants in Cancer
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- 9,10-Deepithio-9,10-Didehydroacanthifolicin
- Calyculin A
- (2S,5R,8S,11R,12S,15S,18S,19S,E)-8-ISOBUTYL-18-((5S,6S)-6-METHOXY-3,5-DIMETHYL-7-PHENYLHEPTYL)-1,2,5,12,15,19-HEXAMETHYL-3,6,9,13,16,20,25-HEPTAOXO-1,4,7,10,14,17,21-HEPTAAZACYCLOPENTACOS-21-ENE-11,22-DICARBOXYLIC ACID
- Motuporin
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IL3RA and SGK2 |
interleukin 3 receptor, alpha (low affinity) |
serum/glucocorticoid regulated kinase 2 |
- Signaling by GPCR
- G-protein beta:gamma signalling
- Cytokine Signaling in Immune system
- GPCR downstream signaling
- Signaling by Interleukins
- Interleukin receptor SHC signaling
- G beta:gamma signalling through PI3Kgamma
- Interleukin receptor SHC signaling
- GPVI-mediated activation cascade
- Interleukin-2 signaling
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
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- Ion channel transport
- Stimuli-sensing channels
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CXCL8 and BAG6 |
chemokine (C-X-C motif) ligand 8 |
BCL2-associated athanogene 6 |
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- Class A/1 (Rhodopsin-like receptors)
- Cellular Senescence
- ATF4 activates genes
- Senescence-Associated Secretory Phenotype (SASP)
- GPCR ligand binding
- Metabolic disorders of biological oxidation enzymes
- GPCR downstream signaling
- Peptide ligand-binding receptors
- Chemokine receptors bind chemokines
- G alpha (i) signalling events
- PERK regulates gene expression
- Unfolded Protein Response (UPR)
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IL15 and TRAF3 |
interleukin 15 |
TNF receptor-associated factor 3 |
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- Activated TLR4 signalling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- TRAF3-dependent IRF activation pathway
- Toll-Like Receptors Cascades
- Negative regulators of RIG-I/MDA5 signaling
- TRIF-mediated TLR3/TLR4 signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- MyD88-independent cascade
- Innate Immune System
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
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IL16 and KCNJ2 |
interleukin 16 |
potassium channel, inwardly rectifying subfamily J, member 2 |
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- GABA B receptor activation
- Inwardly rectifying K+ channels
- GABA receptor activation
- Activation of G protein gated Potassium channels
- Classical Kir channels
- Activation of GABAB receptors
- Potassium Channels
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- G protein gated Potassium channels
- Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
- Transmission across Chemical Synapses
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TNFRSF9 and TRAF3 |
tumor necrosis factor receptor superfamily, member 9 |
TNF receptor-associated factor 3 |
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- Activated TLR4 signalling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- TRAF3-dependent IRF activation pathway
- Toll-Like Receptors Cascades
- Negative regulators of RIG-I/MDA5 signaling
- TRIF-mediated TLR3/TLR4 signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- MyD88-independent cascade
- Innate Immune System
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
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INS and TCF4 |
insulin |
transcription factor 4 |
- Synthesis, secretion, and deacylation of Ghrelin
- Insulin receptor signalling cascade
- Integration of energy metabolism
- Regulation of insulin secretion
- IRS-related events
- SHC-related events
- Insulin receptor recycling
- Peptide hormone metabolism
- IRS activation
- Regulation of beta-cell development
- Signal attenuation
- Regulation of gene expression in beta cells
- Insulin processing
- SHC activation
- Signaling by Insulin receptor
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- CDO in myogenesis
- Myogenesis
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INSIG1 and PSMC3 |
insulin induced gene 1 |
proteasome (prosome, macropain) 26S subunit, ATPase, 3 |
- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- Metabolism of lipids and lipoproteins
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- Hedgehog 'off' state
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- T41 mutants of beta-catenin aren't phosphorylated
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- Stabilization of p53
- S33 mutants of beta-catenin aren't phosphorylated
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Mitotic G1-G1/S phases
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- DNA Replication Pre-Initiation
- S45 mutants of beta-catenin aren't phosphorylated
- APC/C:Cdc20 mediated degradation of mitotic proteins
- Regulation of APC/C activators between G1/S and early anaphase
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Autodegradation of the E3 ubiquitin ligase COP1
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Adaptive Immune System
- CDK-mediated phosphorylation and removal of Cdc6
- Hedgehog ligand biogenesis
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Separation of Sister Chromatids
- HIV Infection
- Ubiquitin-dependent degradation of Cyclin D
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Autodegradation of Cdh1 by Cdh1:APC/C
- p53-Dependent G1 DNA Damage Response
- S37 mutants of beta-catenin aren't phosphorylated
- XAV939 inhibits tankyrase, stabilizing AXIN
- p53-Independent DNA Damage Response
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Vpu mediated degradation of CD4
- Synthesis of DNA
- M/G1 Transition
- Ubiquitin-dependent degradation of Cyclin D1
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Signaling by Hedgehog
- Regulation of mitotic cell cycle
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- p53-Dependent G1/S DNA damage checkpoint
- truncated APC mutants destabilize the destruction complex
- TCF7L2 mutants don't bind CTBP
- Signaling by Wnt
- Cyclin E associated events during G1/S transition
- APC/C:Cdc20 mediated degradation of Securin
- AUF1 (hnRNP D0) destabilizes mRNA
- CDK-mediated phosphorylation and removal of Cdc6
- RNF mutants show enhanced WNT signaling and proliferation
- G1/S Transition
- truncations of AMER1 destabilize the destruction complex
- Processing-defective Hh variants abrogate ligand secretion
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Cyclin A:Cdk2-associated events at S phase entry
- SCF(Skp2)-mediated degradation of p27/p21
- Mitotic Metaphase and Anaphase
- Regulation of ornithine decarboxylase (ODC)
- Antigen processing: Ubiquitination & Proteasome degradation
- Orc1 removal from chromatin
- Mitotic Anaphase
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Metabolism of amino acids and derivatives
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- Regulation of DNA replication
- Cell Cycle, Mitotic
- beta-catenin independent WNT signaling
- Orc1 removal from chromatin
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- Cross-presentation of soluble exogenous antigens (endosomes)
- Antigen processing-Cross presentation
- CDT1 association with the CDC6:ORC:origin complex
- ER-Phagosome pathway
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INSIG1 and SREBF2 |
insulin induced gene 1 |
sterol regulatory element binding transcription factor 2 |
- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- Metabolism of lipids and lipoproteins
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- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- PPARA activates gene expression
- Fatty acid, triacylglycerol, and ketone body metabolism
- Metabolism of lipids and lipoproteins
- Transcriptional regulation of white adipocyte differentiation
- Activation of gene expression by SREBF (SREBP)
- Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
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INSIG1 and VCP |
insulin induced gene 1 |
valosin containing protein |
- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- Metabolism of lipids and lipoproteins
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- HSF1 activation
- Hedgehog ligand biogenesis
- Processing-defective Hh variants abrogate ligand secretion
- Hh ligand biogenesis disease
- Signaling by Hedgehog
- Cellular response to heat stress
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INSIG1 and PSMA7 |
insulin induced gene 1 |
proteasome (prosome, macropain) subunit, alpha type, 7 |
- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- Metabolism of lipids and lipoproteins
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- Hedgehog 'off' state
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- T41 mutants of beta-catenin aren't phosphorylated
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- Stabilization of p53
- S33 mutants of beta-catenin aren't phosphorylated
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Mitotic G1-G1/S phases
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- DNA Replication Pre-Initiation
- S45 mutants of beta-catenin aren't phosphorylated
- APC/C:Cdc20 mediated degradation of mitotic proteins
- Regulation of APC/C activators between G1/S and early anaphase
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Autodegradation of the E3 ubiquitin ligase COP1
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Adaptive Immune System
- CDK-mediated phosphorylation and removal of Cdc6
- Hedgehog ligand biogenesis
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Separation of Sister Chromatids
- HIV Infection
- Ubiquitin-dependent degradation of Cyclin D
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Autodegradation of Cdh1 by Cdh1:APC/C
- p53-Dependent G1 DNA Damage Response
- S37 mutants of beta-catenin aren't phosphorylated
- XAV939 inhibits tankyrase, stabilizing AXIN
- p53-Independent DNA Damage Response
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Vpu mediated degradation of CD4
- Synthesis of DNA
- M/G1 Transition
- Ubiquitin-dependent degradation of Cyclin D1
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Signaling by Hedgehog
- Regulation of mitotic cell cycle
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- p53-Dependent G1/S DNA damage checkpoint
- truncated APC mutants destabilize the destruction complex
- TCF7L2 mutants don't bind CTBP
- Signaling by Wnt
- Cyclin E associated events during G1/S transition
- APC/C:Cdc20 mediated degradation of Securin
- AUF1 (hnRNP D0) destabilizes mRNA
- CDK-mediated phosphorylation and removal of Cdc6
- RNF mutants show enhanced WNT signaling and proliferation
- G1/S Transition
- truncations of AMER1 destabilize the destruction complex
- Processing-defective Hh variants abrogate ligand secretion
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Cyclin A:Cdk2-associated events at S phase entry
- SCF(Skp2)-mediated degradation of p27/p21
- Mitotic Metaphase and Anaphase
- Regulation of ornithine decarboxylase (ODC)
- Antigen processing: Ubiquitination & Proteasome degradation
- Orc1 removal from chromatin
- Mitotic Anaphase
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Metabolism of amino acids and derivatives
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- Regulation of DNA replication
- Cell Cycle, Mitotic
- beta-catenin independent WNT signaling
- Orc1 removal from chromatin
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- Cross-presentation of soluble exogenous antigens (endosomes)
- Antigen processing-Cross presentation
- CDT1 association with the CDC6:ORC:origin complex
- ER-Phagosome pathway
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INSIG1 and SCAP |
insulin induced gene 1 |
SREBF chaperone |
- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- Metabolism of lipids and lipoproteins
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- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- Metabolism of lipids and lipoproteins
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EIF3E and PRRC2A |
eukaryotic translation initiation factor 3, subunit E |
proline-rich coiled-coil 2A |
- Ribosomal scanning and start codon recognition
- Translation initiation complex formation
- Formation of the ternary complex, and subsequently, the 43S complex
- GTP hydrolysis and joining of the 60S ribosomal subunit
- Translation
- Eukaryotic Translation Initiation
- Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
- Formation of a pool of free 40S subunits
- Cap-dependent Translation Initiation
- L13a-mediated translational silencing of Ceruloplasmin expression
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IRAK1 and NTRK3 |
interleukin-1 receptor-associated kinase 1 |
neurotrophic tyrosine kinase, receptor, type 3 |
- NF-kB is activated and signals survival
- p75NTR recruits signalling complexes
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- IRAK1 recruits IKK complex
- Toll Like Receptor TLR1:TLR2 Cascade
- Activated TLR4 signalling
- MyD88 cascade initiated on plasma membrane
- Toll Like Receptor 5 (TLR5) Cascade
- NOD1/2 Signaling Pathway
- p75NTR signals via NF-kB
- MyD88 dependent cascade initiated on endosome
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Toll Like Receptor 9 (TLR9) Cascade
- IRAK1 recruits IKK complex
- activated TAK1 mediates p38 MAPK activation
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- Innate Immune System
- Signalling by NGF
- MAP kinase activation in TLR cascade
- TRIF-mediated TLR3/TLR4 signaling
- Cytokine Signaling in Immune system
- p75 NTR receptor-mediated signalling
- MyD88-independent cascade
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by Interleukins
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Interleukin-1 signaling
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
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IRAK2 and STT3A |
interleukin-1 receptor-associated kinase 2 |
STT3A, subunit of the oligosaccharyltransferase complex (catalytic) |
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- Toll Like Receptor TLR1:TLR2 Cascade
- Activated TLR4 signalling
- MyD88 cascade initiated on plasma membrane
- Toll Like Receptor 5 (TLR5) Cascade
- NOD1/2 Signaling Pathway
- MyD88 dependent cascade initiated on endosome
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Toll Like Receptor 9 (TLR9) Cascade
- activated TAK1 mediates p38 MAPK activation
- Innate Immune System
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- IRAK2 mediated activation of TAK1 complex
- IRAK2 mediated activation of TAK1 complex
- TRIF-mediated TLR3/TLR4 signaling
- MAP kinase activation in TLR cascade
- Cytokine Signaling in Immune system
- MyD88-independent cascade
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by Interleukins
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Interleukin-1 signaling
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
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- Defective ALG2 causes ALG2-CDG (CDG-1i)
- Diseases of glycosylation
- Defective ALG3 causes ALG3-CDG (CDG-1d)
- Post-translational protein modification
- Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
- Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
- Defective MGAT2 causes MGAT2-CDG (CDG-2a)
- Defective ALG1 causes ALG1-CDG (CDG-1k)
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Defective RFT1 causes RFT1-CDG (CDG-1n)
- Defective ALG6 causes ALG6-CDG (CDG-1c)
- Defective MOGS causes MOGS-CDG (CDG-2b)
- Asparagine N-linked glycosylation
- Defective ALG8 causes ALG8-CDG (CDG-1h)
- Defective ALG9 causes ALG9-CDG (CDG-1l)
- Defective MAN1B1 causes MRT15
- Defective MPDU1 causes MPDU1-CDG (CDG-1f)
- Defective ALG12 causes ALG12-CDG (CDG-1g)
- Diseases associated with N-glycosylation of proteins
- Defective ALG11 causes ALG11-CDG (CDG-1p)
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