| DLG1 and GRIN2A |
discs, large homolog 1 (Drosophila) |
glutamate receptor, ionotropic, N-methyl D-aspartate 2A |
- Axon guidance
- Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
- L1CAM interactions
- NrCAM interactions
- Activation of Kainate Receptors upon glutamate binding
- Activation of Ca-permeable Kainate Receptor
- Trafficking of AMPA receptors
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Ionotropic activity of Kainate Receptors
- Transmission across Chemical Synapses
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- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- CREB phosphorylation through the activation of CaMKII
- CREB phosphorylation through the activation of Ras
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Unblocking of NMDA receptor, glutamate binding and activation
- Ras activation uopn Ca2+ infux through NMDA receptor
- Post NMDA receptor activation events
- Transmission across Chemical Synapses
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- L-Glutamic Acid
- Glycine
- Meperidine
- Felbamate
- Memantine
- Halothane
- Tenocyclidine
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| DLG2 and KCNJ2 |
discs, large homolog 2 (Drosophila) |
potassium channel, inwardly rectifying subfamily J, member 2 |
|
- GABA B receptor activation
- Inwardly rectifying K+ channels
- GABA receptor activation
- Activation of G protein gated Potassium channels
- Classical Kir channels
- Activation of GABAB receptors
- Potassium Channels
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- G protein gated Potassium channels
- Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
- Transmission across Chemical Synapses
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| DLG2 and GRIN2A |
discs, large homolog 2 (Drosophila) |
glutamate receptor, ionotropic, N-methyl D-aspartate 2A |
|
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- CREB phosphorylation through the activation of CaMKII
- CREB phosphorylation through the activation of Ras
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Unblocking of NMDA receptor, glutamate binding and activation
- Ras activation uopn Ca2+ infux through NMDA receptor
- Post NMDA receptor activation events
- Transmission across Chemical Synapses
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- L-Glutamic Acid
- Glycine
- Meperidine
- Felbamate
- Memantine
- Halothane
- Tenocyclidine
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| DLG3 and GRIN2A |
discs, large homolog 3 (Drosophila) |
glutamate receptor, ionotropic, N-methyl D-aspartate 2A |
- Axon guidance
- L1CAM interactions
- NrCAM interactions
- Activation of Kainate Receptors upon glutamate binding
- Activation of Ca-permeable Kainate Receptor
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Ionotropic activity of Kainate Receptors
- Transmission across Chemical Synapses
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- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- CREB phosphorylation through the activation of CaMKII
- CREB phosphorylation through the activation of Ras
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Unblocking of NMDA receptor, glutamate binding and activation
- Ras activation uopn Ca2+ infux through NMDA receptor
- Post NMDA receptor activation events
- Transmission across Chemical Synapses
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- L-Glutamic Acid
- Glycine
- Meperidine
- Felbamate
- Memantine
- Halothane
- Tenocyclidine
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| DLG3 and KCNJ2 |
discs, large homolog 3 (Drosophila) |
potassium channel, inwardly rectifying subfamily J, member 2 |
- Axon guidance
- L1CAM interactions
- NrCAM interactions
- Activation of Kainate Receptors upon glutamate binding
- Activation of Ca-permeable Kainate Receptor
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Ionotropic activity of Kainate Receptors
- Transmission across Chemical Synapses
|
- GABA B receptor activation
- Inwardly rectifying K+ channels
- GABA receptor activation
- Activation of G protein gated Potassium channels
- Classical Kir channels
- Activation of GABAB receptors
- Potassium Channels
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- G protein gated Potassium channels
- Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
- Transmission across Chemical Synapses
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| DLG4 and GRIN2A |
discs, large homolog 4 (Drosophila) |
glutamate receptor, ionotropic, N-methyl D-aspartate 2A |
- Axon guidance
- L1CAM interactions
- Activation of Kainate Receptors upon glutamate binding
- CREB phosphorylation through the activation of Ras
- Trafficking of AMPA receptors
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- CREB phosphorylation through the activation of CaMKII
- NrCAM interactions
- Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
- Activation of Ca-permeable Kainate Receptor
- Unblocking of NMDA receptor, glutamate binding and activation
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Ionotropic activity of Kainate Receptors
- Ras activation uopn Ca2+ infux through NMDA receptor
- Post NMDA receptor activation events
- Transmission across Chemical Synapses
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- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- CREB phosphorylation through the activation of CaMKII
- CREB phosphorylation through the activation of Ras
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Unblocking of NMDA receptor, glutamate binding and activation
- Ras activation uopn Ca2+ infux through NMDA receptor
- Post NMDA receptor activation events
- Transmission across Chemical Synapses
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- L-Glutamic Acid
- Glycine
- Meperidine
- Felbamate
- Memantine
- Halothane
- Tenocyclidine
|
|
|
| DLG4 and KCNJ2 |
discs, large homolog 4 (Drosophila) |
potassium channel, inwardly rectifying subfamily J, member 2 |
- Axon guidance
- L1CAM interactions
- Activation of Kainate Receptors upon glutamate binding
- CREB phosphorylation through the activation of Ras
- Trafficking of AMPA receptors
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- CREB phosphorylation through the activation of CaMKII
- NrCAM interactions
- Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
- Activation of Ca-permeable Kainate Receptor
- Unblocking of NMDA receptor, glutamate binding and activation
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Ionotropic activity of Kainate Receptors
- Ras activation uopn Ca2+ infux through NMDA receptor
- Post NMDA receptor activation events
- Transmission across Chemical Synapses
|
- GABA B receptor activation
- Inwardly rectifying K+ channels
- GABA receptor activation
- Activation of G protein gated Potassium channels
- Classical Kir channels
- Activation of GABAB receptors
- Potassium Channels
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- G protein gated Potassium channels
- Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
- Transmission across Chemical Synapses
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| DLG4 and GRIK1 |
discs, large homolog 4 (Drosophila) |
glutamate receptor, ionotropic, kainate 1 |
- Axon guidance
- L1CAM interactions
- Activation of Kainate Receptors upon glutamate binding
- CREB phosphorylation through the activation of Ras
- Trafficking of AMPA receptors
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- CREB phosphorylation through the activation of CaMKII
- NrCAM interactions
- Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
- Activation of Ca-permeable Kainate Receptor
- Unblocking of NMDA receptor, glutamate binding and activation
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Ionotropic activity of Kainate Receptors
- Ras activation uopn Ca2+ infux through NMDA receptor
- Post NMDA receptor activation events
- Transmission across Chemical Synapses
|
- Activation of Kainate Receptors upon glutamate binding
- Activation of Ca-permeable Kainate Receptor
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Activation of Na-permeable Kainate Receptors
- Ionotropic activity of Kainate Receptors
- Transmission across Chemical Synapses
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- L-Glutamic Acid
- Topiramate
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| DMD and DISC1 |
dystrophin |
disrupted in schizophrenia 1 |
- Striated Muscle Contraction
- Non-integrin membrane-ECM interactions
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| DYNC1H1 and TNIK |
dynein, cytoplasmic 1, heavy chain 1 |
TRAF2 and NCK interacting kinase |
- Organelle biogenesis and maintenance
- Assembly of the primary cilium
- G2/M Transition
- Anchoring of the basal body to the plasma membrane
- Regulation of PLK1 Activity at G2/M Transition
- Cell Cycle, Mitotic
- Loss of proteins required for interphase microtubule organization from the centrosome
- Loss of Nlp from mitotic centrosomes
- MHC class II antigen presentation
- Centrosome maturation
- Mitotic G2-G2/M phases
- Recruitment of mitotic centrosome proteins and complexes
- Adaptive Immune System
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- Oxidative Stress Induced Senescence
- Cellular Senescence
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| DYNC1H1 and DISC1 |
dynein, cytoplasmic 1, heavy chain 1 |
disrupted in schizophrenia 1 |
- Organelle biogenesis and maintenance
- Assembly of the primary cilium
- G2/M Transition
- Anchoring of the basal body to the plasma membrane
- Regulation of PLK1 Activity at G2/M Transition
- Cell Cycle, Mitotic
- Loss of proteins required for interphase microtubule organization from the centrosome
- Loss of Nlp from mitotic centrosomes
- MHC class II antigen presentation
- Centrosome maturation
- Mitotic G2-G2/M phases
- Recruitment of mitotic centrosome proteins and complexes
- Adaptive Immune System
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| DOK1 and MAP4K4 |
docking protein 1, 62kDa (downstream of tyrosine kinase 1) |
mitogen-activated protein kinase kinase kinase kinase 4 |
- IRS-related events triggered by IGF1R
- Insulin receptor signalling cascade
- IRS activation
- IRS-mediated signalling
- Signal attenuation
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- IRS-related events
- IGF1R signaling cascade
- PI3K Cascade
- PI3K Cascade
- Signaling by Insulin receptor
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- Oxidative Stress Induced Senescence
- Cellular Senescence
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| DPP4 and CXCL12 |
dipeptidyl-peptidase 4 |
chemokine (C-X-C motif) ligand 12 |
- Peptide hormone metabolism
- Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
- Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
- Incretin synthesis, secretion, and inactivation
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- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- Class A/1 (Rhodopsin-like receptors)
- Signaling by ERBB4
- GPCR ligand binding
- Metabolic disorders of biological oxidation enzymes
- GPCR downstream signaling
- Nuclear signaling by ERBB4
- Peptide ligand-binding receptors
- Chemokine receptors bind chemokines
- G alpha (i) signalling events
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- Atorvastatin
- Sitagliptin
- 2-Amino-3-Methyl-1-Pyrrolidin-1-Yl-Butan-1-One
- 5-(Aminomethyl)-6-(2,4-Dichlorophenyl)-2-(3,5-Dimethoxyphenyl)Pyrimidin-4-Amine
- Alpha-D-Mannose
- (2s)-Pyrrolidin-2-Ylmethylamine
- Iodo-Phenylalanine
- Diisopropylphosphono Group
- 1-(1-phenylcyclopentyl)methylamine
- (S)-2-[(R)-3-amino-4-(2-fluorophenyl)butyryl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
- Vildagliptin
- Alogliptin
- Saxagliptin
- (1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-PROP-1-YN-1-YLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE
- N-(TRANS-4-{(1S,2S)-2-AMINO-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-1-METHYL-3-OXOPROPYL}CYCLOHEXYL)-N-METHYLACETAMIDE
- (2S,3S)-4-cyclopropyl-3-{(3R,5R)-3-[2-fluoro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazolidin-5-yl}-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
- (2S,3S)-3-{3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-cyclopentylidene-4-cyclopropyl-1-fluorobutan-2-amine
- (3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-(quinoxalin-2-ylcarbonyl)pyrrolidin-3-amine
- (7R,8R)-8-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydroimidazo[1,2-a:4,5-c\']dipyridin-7-amine
- (2S,3S)-3-{3-[4-(METHYLSULFONYL)PHENYL]-1,2,4-OXADIAZOL-5-YL}-1-OXO-1-PYRROLIDIN-1-YLBUTAN-2-AMINE
- (1S,2R,5S)-5-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-2-(2,4,5-TRIFLUOROPHENYL)CYCLOHEXANAMINE
- (2R)-4-[(8R)-8-METHYL-2-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[1,5-A]PYRAZIN-7(8H)-YL]-4-OXO-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE
- (2S,3S)-3-AMINO-4-(3,3-DIFLUOROPYRROLIDIN-1-YL)-N,N-DIMETHYL-4-OXO-2-(TRANS-4-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-6-YLCYCLOHEXYL)BUTANAMIDE
- (2S,3S)-3-AMINO-4-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-N,N-DIMETHYL-4-OXO-2-(TRANS-4-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-5-YLCYCLOHEXYL)BUTANAMIDE
- (3R)-4-[(3R)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOYL]-3-METHYL-1,4-DIAZEPAN-2-ONE
- 4\'-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]biphenyl-3-carboxamide
- (2R,3R)-7-(methylsulfonyl)-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine
- 7-(aminomethyl)-6-(2-chlorophenyl)-1-methyl-1H-benzimidazole-5-carbonitrile
- (3R)-4-[(3R)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOYL]-3-(2,2,2-TRIFLUOROETHYL)-1,4-DIAZEPAN-2-ONE
- METHYL 4-{[({[(2R,5S)-5-{[(2S)-2-(AMINOMETHYL)PYRROLIDIN-1-YL]CARBONYL}PYRROLIDIN-2-YL]METHYL}AMINO)CARBONYL]AMINO}BENZOATE
- (1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-ETHYNYLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE
- 1-biphenyl-2-ylmethanamine
- (1S,3S,5S)-2-{(2S)-2-amino-2-[(1R,3S,5R,7S)-3-hydroxytricyclo[3.3.1.1~3,7~]dec-1-yl]acetyl}-2-azabicyclo[3.1.0]hexane-3-carbonitrile
- (2R)-N-[(2R)-2-(DIHYDROXYBORYL)-1-L-PROLYLPYRROLIDIN-2-YL]-N-[(5R)-5-(DIHYDROXYBORYL)-1-L-PROLYLPYRROLIDIN-2-YL]-L-PROLINAMIDE
- (3R,4S)-1-{6-[3-(METHYLSULFONYL)PHENYL]PYRIMIDIN-4-YL}-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINE
- N-({(2S)-1-[(3R)-3-AMINO-4-(2-FLUOROPHENYL)BUTANOYL]PYRROLIDIN-2-YL}METHYL)BENZAMIDE
- (4R,5R)-5-AMINO-1-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-4-(2,4,5-TRIFLUOROPHENYL)PIPERIDIN-2-ONE
- (3R,4S)-1-(3,4-DIMETHOXYPHENYL)-3-(3-METHYLPHENYL)PIPERIDIN-4-AMINE
- 1-[2-(S)-AMINO-3-BIPHENYL-4-YL-PROPIONYL]-PYRROLIDINE-2-(S)-CARBONITRILE
- (1S,6R)-3-{[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]CARBONYL}-6-(2,4,5-TRIFLUOROPHENYL)CYCLOHEX-3-EN-1-AMINE
- (2R)-4-(2-BENZOYL-1,2-DIAZEPAN-1-YL)-4-OXO-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE
- (3R,4R)-1-{6-[3-(METHYLSULFONYL)PHENYL]PYRIMIDIN-4-YL}-4-(2,4,5-TRIFLUOROPHENYL)PIPERIDIN-3-AMINE
- 2-(4-{(3S,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl}piperazin-1-yl)pyrimidine
- N-({(2S)-1-[(3R)-3-amino-4-(3-chlorophenyl)butanoyl]pyrrolidin-2-yl}methyl)-3-(methylsulfonyl)benzamide
- (3R,4S)-1-[6-(6-METHOXYPYRIDIN-3-YL)PYRIMIDIN-4-YL]-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINE
- 6-(4-{(1S,2S)-2-AMINO-1-[(DIMETHYLAMINO)CARBONYL]-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-3-OXOPROPYL}PHENYL)-1H-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-4-IUM
- 7-BENZYL-1,3-DIMETHYL-8-PIPERAZIN-1-YL-3,7-DIHYDRO-PURINE-2,6-DIONE
- 2-({2-[(3R)-3-AMINOPIPERIDIN-1-YL]-4-OXOQUINAZOLIN-3(4H)-YL}METHYL)BENZONITRILE
- 4-[(3R)-3-{[2-(4-FLUOROPHENYL)-2-OXOETHYL]AMINO}BUTYL]BENZAMIDE
- 2-({8-[(3R)-3-AMINOPIPERIDIN-1-YL]-1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL}METHYL)BENZONITRILE
- Linagliptin
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| DPT and BAG6 |
dermatopontin |
BCL2-associated athanogene 6 |
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| DPYD and GOPC |
dihydropyrimidine dehydrogenase |
golgi-associated PDZ and coiled-coil motif containing |
- Pyrimidine catabolism
- Pyrimidine metabolism
- Metabolism of nucleotides
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- (5s)-5-Iododihydro-2,4(1h,3h)-Pyrimidinedione
- Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate
- 6-Carboxymethyluracil
- Flavin-Adenine Dinucleotide
- Riboflavin Monophosphate
- Uracil
- 5-Iodouracil
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| DPYD and LXN |
dihydropyrimidine dehydrogenase |
latexin |
- Pyrimidine catabolism
- Pyrimidine metabolism
- Metabolism of nucleotides
|
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- (5s)-5-Iododihydro-2,4(1h,3h)-Pyrimidinedione
- Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate
- 6-Carboxymethyluracil
- Flavin-Adenine Dinucleotide
- Riboflavin Monophosphate
- Uracil
- 5-Iodouracil
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| DPYSL2 and TNIK |
dihydropyrimidinase-like 2 |
TRAF2 and NCK interacting kinase |
- Axon guidance
- Semaphorin interactions
- L1CAM interactions
- CRMPs in Sema3A signaling
- Recycling pathway of L1
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- Oxidative Stress Induced Senescence
- Cellular Senescence
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| DPYSL2 and DISC1 |
dihydropyrimidinase-like 2 |
disrupted in schizophrenia 1 |
- Axon guidance
- Semaphorin interactions
- L1CAM interactions
- CRMPs in Sema3A signaling
- Recycling pathway of L1
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| DPYSL3 and TNIK |
dihydropyrimidinase-like 3 |
TRAF2 and NCK interacting kinase |
- Axon guidance
- Semaphorin interactions
- CRMPs in Sema3A signaling
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- Oxidative Stress Induced Senescence
- Cellular Senescence
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| DPYSL3 and DISC1 |
dihydropyrimidinase-like 3 |
disrupted in schizophrenia 1 |
- Axon guidance
- Semaphorin interactions
- CRMPs in Sema3A signaling
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