NAE1

Gene Name		NEDD8 activating enzyme E1 subunit 1
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Binding NEDD8 Activating Enzyme Activity Ubiquitin Protein Ligase Binding Protein Heterodimerization Activity
	Biological Process	Signal Transduction Mitotic DNA Replication Checkpoint Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Protein Neddylation Neuron Apoptotic Process
Pathways
Drugs		Adenosine triphosphate
Diseases
GWAS
Protein-protein Interactions		11 interactors: ALG8 APP NEDD8 SREBF2 TP53BP2 TRIP12 UBA3 UBC UBE2F UBE2M UBQLN4
Entrez ID		8883
HPRD ID		04545
Ensembl ID		ENSG00000159593
Uniprot IDs		A6NCK0 A8MU28 Q13564
PDB IDs		1R4M 1R4N 1TT5 1YOV 2NVU 3DBH 3DBL 3DBR 3GZN
Enriched GO Terms of Interacting Partners?		Protein Neddylation Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cellular Protein Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Cycle Regulation Of ERBB Signaling Pathway Protein Metabolic Process Oligosaccharide-lipid Intermediate Biosynthetic Process Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Synaptic Growth At Neuromuscular Junction Negative Regulation Of Protein Ubiquitination Signal Transduction By P53 Class Mediator Cholesterol Metabolic Process Ubiquitin-dependent Protein Catabolic Process Collateral Sprouting In Absence Of Injury Negative Regulation Of Histone H2A K63-linked Ubiquitination Endomitotic Cell Cycle Modification-dependent Protein Catabolic Process Sterol Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Histone Ubiquitination Negative Regulation Of Protein K63-linked Ubiquitination Notch Signaling Pathway Cellular Protein Catabolic Process Protein Ubiquitination Cellular Response To Growth Factor Stimulus Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Cholesterol Efflux Response To Growth Factor Protein Catabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Protein K63-linked Ubiquitination Regulation Of Proteolysis Axon Choice Point Recognition Negative Regulation Of Double-strand Break Repair Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of DNA Repair Intracellular Receptor Signaling Pathway Proteolysis Regulation Of Protein Ubiquitination Neuron Remodeling Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process
Tagcloud ?		addressed app bp1 bring clonogenic constructs conversely elusive emerged hnscc hnsccs hpv16 invovled ionizing modality naturally nedd8 neddylation oropharyngeal radioresistant radiosensitive radiosensitivity radiotherapy rays scc90 sirnas sq20b subpopulation upci