PROZ

Gene Name		protein Z, vitamin K-dependent plasma glycoprotein
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Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Lumen Golgi Lumen Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding
	Biological Process	Proteolysis Blood Coagulation Peptidyl-glutamic Acid Carboxylation Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Post-translational protein modification Removal of aminoterminal propeptides from gamma-carboxylated proteins Gamma-carboxylation of protein precursors Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Drugs		Menadione
Diseases
GWAS		Factor VII ( 17903294)
Protein-protein Interactions		1 interactors: F2
Entrez ID		8858
HPRD ID		07182
Ensembl ID		ENSG00000126231
Uniprot IDs		P22891
PDB IDs		3F1S 3H5C
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Fibrinolysis Peptidyl-glutamic Acid Carboxylation Regulation Of Fibrinolysis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Platelet Activation Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process Regulation Of Astrocyte Differentiation Fibrinolysis Regulation Of Platelet Activation Positive Regulation Of Blood Coagulation Negative Regulation Of Glial Cell Differentiation Regulation Of Collagen Metabolic Process Positive Regulation Of Calcium Ion Transport Into Cytosol Acute-phase Response Positive Regulation Of Coagulation Positive Regulation Of Wound Healing Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Wound Healing Acute Inflammatory Response Regulation Of Glial Cell Differentiation Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Calcium Ion Transport Regulation Of Blood Coagulation Regulation Of Gliogenesis Positive Regulation Of Cell Growth Regulation Of Wound Healing Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Cell Shape Regulation Of Ion Homeostasis Protein Activation Cascade Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Cytosolic Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Platelet Activation Positive Regulation Of Ion Transport Post-translational Protein Modification Positive Regulation Of Growth Leukocyte Migration Positive Regulation Of Intracellular Transport Negative Regulation Of Neurogenesis
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