PDE5A

Gene Name		phosphodiesterase 5A, cGMP-specific
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Gene Ontology Annotations	Cellular Component	Cellular_component Cytosol
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity CGMP Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Signal Transduction Blood Coagulation Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of CGMP Metabolic Process Negative Regulation Of T Cell Proliferation Positive Regulation Of MAP Kinase Activity CGMP Catabolic Process Negative Regulation Of Cardiac Muscle Contraction Relaxation Of Cardiac Muscle Positive Regulation Of Oocyte Development
Pathways		Platelet homeostasis Nitric oxide stimulates guanylate cyclase cGMP effects
Drugs		Sildenafil Theophylline Pentoxifylline Tadalafil Vardenafil Dipyridamole Guanosine-5\'-Monophosphate Gamma-Glutamyl[S-(2-Iodobenzyl)Cysteinyl]Glycine Citric Acid Avanafil Udenafil 3-ISOBUTYL-1-METHYLXANTHINE 5-ethoxy-4-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)thiophene-2-sulfonamide
Diseases
GWAS
Protein-protein Interactions		2 interactors: CASP3 PRKG1
Entrez ID		8654
HPRD ID		04497
Ensembl ID		ENSG00000138735
Uniprot IDs		G5E9C5 O76074
PDB IDs		1RKP 1T9R 1T9S 1TBF 1UDT 1UDU 1UHO 1XOZ 1XP0 2CHM 2H40 2H42 2H44 2XSS 3B2R 3BJC 3HC8 3HDZ 3JWQ 3JWR 3LFV 3MF0 3SHY 3SHZ 3SIE 3TGE 3TGG 3TSE 3TSF 4G2W 4G2Y
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Homotypic Cell-cell Adhesion Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Cell Activation Glial Cell Apoptotic Process Regulation Of Apoptotic DNA Fragmentation Regulation Of Cell Adhesion Relaxation Of Vascular Smooth Muscle CGMP-mediated Signaling Relaxation Of Smooth Muscle Negative Regulation Of Platelet Aggregation Response To Wounding Negative Regulation Of Activated T Cell Proliferation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Negative Regulation Of Smooth Muscle Contraction Regulation Of Platelet Aggregation Negative Regulation Of B Cell Proliferation Negative Regulation Of Platelet Activation Apoptotic DNA Fragmentation Negative Regulation Of Muscle Contraction Platelet Formation Platelet Morphogenesis Relaxation Of Muscle Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Neuron Differentiation Hippo Signaling Release Of Cytochrome C From Mitochondria Cyclic-nucleotide-mediated Signaling Apoptotic Nuclear Changes Regulation Of Platelet Activation Vasodilation Regulation Of Activated T Cell Proliferation B Cell Homeostasis T Cell Homeostasis Negative Regulation Of B Cell Activation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Generation Of Neurons Regulation Of Smooth Muscle Contraction Negative Regulation Of Blood Coagulation Neuron Apoptotic Process Regulation Of B Cell Proliferation Negative Regulation Of Coagulation Neurogenesis Positive Regulation Of Neuron Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Negative Regulation Of T Cell Proliferation
Tagcloud ?		4q27 8q24 aberration breakpoint breakpoints cgmp conspicuous deregulated deregulating guanosine hl hodgkin homeobox infiltrated karyotyping monophosphate phosphodiesterase q24 q27 rational reed repress rq shortlisted sildenafil stat1 sternberg therein zhx2