SUV420H2

Gene Name		suppressor of variegation 4-20 homolog 2 (Drosophila)
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Gene Ontology Annotations	Cellular Component	Condensed Nuclear Chromosome, Centromeric Region Nucleoplasm Nuclear Heterochromatin Pericentric Heterochromatin
	Molecular Function	Protein Binding Histone Methyltransferase Activity (H4-K20 Specific)
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Histone H4-K20 Trimethylation
Pathways
Drugs
Diseases
GWAS		Menopause (age at onset) ( 19448619)
Protein-protein Interactions		4 interactors: HIST1H4A RB1 RBL1 RBL2
Entrez ID		84787
HPRD ID		15454
Ensembl ID		ENSG00000133247
Uniprot IDs		Q86Y97
PDB IDs		3RQ4
Enriched GO Terms of Interacting Partners?		Regulation Of Lipid Kinase Activity Chromatin Modification Chromatin Organization Mitotic Cell Cycle Chromosome Organization Regulation Of Lipid Metabolic Process Cell Cycle Regulation Of Kinase Activity Regulation Of Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Sister Chromatid Biorientation Regulation Of Myeloid Cell Differentiation Organelle Organization Chromatin Remodeling Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of Centromere Complex Assembly Histone H4-K20 Demethylation Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Cohesin Localization To Chromatin Regulation Of Phosphorylation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Megakaryocyte Differentiation Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Phosphorus Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Glial Cell Apoptotic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Replication-dependent Nucleosome Assembly Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Protein Localization To Chromosome, Centromeric Region Attachment Of Spindle Microtubules To Kinetochore Regulation Of Gene Expression Positive Regulation Of Macrophage Differentiation Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Methylation On Cytosine Mitotic Sister Chromatid Cohesion Enucleate Erythrocyte Differentiation
Tagcloud ?		aspects breast cancerous clearly clinicopathological ectopic elucidate global goal h3k9me3 h4 h4k20 h4k20me3 importantly independently invasion invasiveness knockdown luminal lysine mammary methyltransferases modification mostly multivariate pathological trimethylation univariate