KMT2D

Gene Name		lysine (K)-specific methyltransferase 2D
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Transcription Regulatory Region DNA Binding
	Biological Process	Oocyte Growth Chromatin Organization Chromatin Silencing Transcription, DNA-templated Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Proliferation Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Estrogen Positive Regulation Of Transcription From RNA Polymerase II Promoter Oogenesis Histone H3-K4 Methylation
Pathways		Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Signaling by Wnt deactivation of the beta-catenin transactivating complex Chromatin modifying enzymes TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-protein Interactions		9 interactors: ASH2L CTNNB1 ESR1 HIST2H3C MEN1 POLR2A SMAD1 SMAD9 UBC
Entrez ID		8085
HPRD ID		03664
Ensembl ID		ENSG00000167548
Uniprot IDs		O14686 Q59FG6 Q6PIA1
PDB IDs		3UVK 4ERQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Gene Expression Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Nucleobase-containing Compound Metabolic Process Response To Transforming Growth Factor Beta Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Cellular Response To Growth Factor Stimulus DNA-templated Transcription, Initiation Response To Growth Factor Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Gene Expression Nitrogen Compound Metabolic Process Osteoblast Fate Commitment Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Ossification Response To Organic Substance Urogenital System Development Response To Organic Cyclic Compound Cellular Response To Organic Cyclic Compound Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development Regulation Of Osteoblast Differentiation Cellular Response To Organic Substance Kidney Epithelium Development
Tagcloud ?		aka belong bile circadian clock closest coactivator coactivators complexes disturbed fluctuation hepatic hepatology homolog impinges livers mechanistic metabolic methyltransferase mll3 mll4 named orphan pivotal regulators retinoid rhythmic transcriptome uncovered