XPNPEP1

Gene Name		X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
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Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Aminopeptidase Activity Manganese Ion Binding Protein Homodimerization Activity Metalloaminopeptidase Activity
	Biological Process	Proteolysis Bradykinin Catabolic Process
Pathways
Drugs
Diseases
GWAS		Biliary atresia ( 20460270)
Protein-protein Interactions		8 interactors: DISC1 GSK3B MAPK9 NUDT3 POLA2 RINT1 UBC UBE2D3
Entrez ID		7511
HPRD ID		03899
Ensembl ID		ENSG00000108039
Uniprot IDs		G8JLB2 Q9NQW7
PDB IDs		3CTZ
Enriched GO Terms of Interacting Partners?		TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Proteolysis Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Wnt Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Innate Immune Response Cellular Localization Response To Growth Factor Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Protein Ubiquitination Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Fc-epsilon Receptor Signaling Pathway Intracellular Transport Regulation Of Innate Immune Response Fc Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Type I Interferon Production Regulation Of Wnt Signaling Pathway Regulation Of Immune Response Positive Regulation Of Protein Modification Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of DNA-templated Transcription In Response To Stress Protein Localization Apoptotic Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Apoptotic Process Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Glycogen Metabolic Process Establishment Of Localization In Cell Programmed Cell Death Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Catabolic Process Cell Death Death MyD88-dependent Toll-like Receptor Signaling Pathway Response To Abiotic Stimulus
Tagcloud ?		aminopeptidase app app1 apps associate biologically causal cleave cytosolic deficiency deficient excretion imino isoforms knocking lethality link mammals microcephaly modest oligopeptide penultimate peptides peptiduria proline ps residue retardation