WHSC1

Gene Name		Wolf-Hirschhorn syndrome candidate 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm
	Molecular Function	Chromatin Binding Protein Binding Zinc Ion Binding Histone-lysine N-methyltransferase Activity Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Membranous Septum Morphogenesis Atrial Septum Primum Morphogenesis Atrial Septum Secundum Morphogenesis Chromatin Organization Transcription, DNA-templated Anatomical Structure Morphogenesis Histone H3-K36 Methylation Histone H4-K20 Methylation Positive Regulation Of Isotype Switching To IgA Isotypes Bone Development Regulation Of Establishment Of Protein Localization Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS
Protein-protein Interactions		7 interactors: APP AR ESR1 HIST1H3A HIST2H3C HIST3H3 MDC1
Entrez ID		7468
HPRD ID		04259
Ensembl ID		ENSG00000109685
Uniprot IDs		O96028
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA Methylation On Cytosine Chromatin Silencing At RDNA Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Intracellular Receptor Signaling Pathway Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Chromatin Silencing DNA Metabolic Process DNA Methylation Intracellular Steroid Hormone Receptor Signaling Pathway Prostate Gland Development Blood Coagulation Hemostasis Negative Regulation Of Gene Expression, Epigenetic DNA Modification Growth Negative Regulation Of Integrin Biosynthetic Process Steroid Hormone Mediated Signaling Pathway Gene Silencing Regulation Of Body Fluid Levels Wound Healing Synaptic Growth At Neuromuscular Junction Hormone-mediated Signaling Pathway Developmental Growth Involved In Morphogenesis Cell Growth Response To Wounding Collateral Sprouting In Absence Of Injury Positive Regulation Of Integrin Biosynthetic Process Prostate Epithelial Cord Elongation Transcription Initiation From RNA Polymerase II Promoter Gene Expression Cellular Response To Steroid Hormone Stimulus Regulation Of Integrin Biosynthetic Process Collateral Sprouting Axon Midline Choice Point Recognition Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Regulation Of Gene Expression, Epigenetic Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Branch Elongation Involved In Mammary Gland Duct Branching Antral Ovarian Follicle Growth DNA-templated Transcription, Initiation Axon Choice Point Recognition Steroid Metabolic Process Chromosome Organization Regulation Of Branching Involved In Prostate Gland Morphogenesis Mammary Gland Branching Involved In Pregnancy
Tagcloud ?		aberrantly amenable backgroundhistone chemotherapies conclusionsour ctd docked h3k27 h3k36 h3k4 h3k79 h3k9 h4k20 hmtases mer methylating methylations mmset modifiers nsd nsd1 nsd2 nsd3 nsds recognizing resultsherein transferases versatility