HNF1B

Gene Name		HNF1 homeobox B
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Endodermal Cell Fate Specification Kidney Development Inner Cell Mass Cell Differentiation Transcription From RNA Polymerase II Promoter Response To Glucose Anterior/posterior Pattern Specification Insulin Secretion Regulation Of Wnt Signaling Pathway Hindbrain Development Endocrine Pancreas Development Regulation Of Pronephros Size Pronephric Nephron Tubule Development Regulation Of Endodermal Cell Fate Specification Positive Regulation Of Transcription, DNA-templated Embryonic Digestive Tract Morphogenesis Branching Morphogenesis Of An Epithelial Tube Pronephros Development Genitalia Development Epithelial Cell Proliferation Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Ureteric Bud Elongation Hepatoblast Differentiation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Regulation Of Branch Elongation Involved In Ureteric Bud Branching Mesonephric Duct Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development
Pathways		Regulation of beta-cell development Regulation of gene expression in early pancreatic precursor cells Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
Drugs
Diseases
GWAS		Endometrial cancer ( 21499250) Ovarian cancer ( 23535730) Prostate cancer ( 20676098 18264096 18264097) Prostate-specific antigen levels ( 21160077) Type 2 diabetes ( 22961080 20581827)
Protein-protein Interactions		6 interactors: ATF1 CREB1 CREBBP HIST1H3A HNF1A PCBD1
Entrez ID		6928
HPRD ID		08926
Ensembl ID		ENSG00000108753
Uniprot IDs		E0YMJ6 P35680 Q6FHW6
PDB IDs		2DA6 2H8R
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Protein Complex Assembly Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Cellular Nitrogen Compound Metabolic Process Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Toll-like Receptor 4 Signaling Pathway RNA Metabolic Process Renal Glucose Absorption Toll-like Receptor Signaling Pathway Positive Regulation Of Metabolic Process Response To Stress Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Cellular Macromolecule Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Innate Immune Response-activating Signal Transduction Macromolecule Biosynthetic Process
Tagcloud ?		a2780 annotation bioinformatics chemicals cystadenocarcinomas drug enrichment erbb focal geo homeobox illustrate illustrated interacted microrna micrornas never omnibus oncomine online ovarian pave perform platinum regulations resistance retrieved serous