SKI

Gene Name		SKI proto-oncogene
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Centrosome Nuclear Body PML Body Transcriptional Repressor Complex Protein Complex
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding SMAD Binding Histone Deacetylase Inhibitor Activity Repressing Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neural Tube Closure Lens Morphogenesis In Camera-type Eye Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Cell Proliferation Negative Regulation Of Cell Proliferation Anterior/posterior Axis Specification Gene Expression Negative Regulation Of Schwann Cell Proliferation Myotube Differentiation Olfactory Bulb Development Myelination In Peripheral Nervous System Positive Regulation Of Wnt Signaling Pathway Embryonic Limb Morphogenesis BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Histone Deacetylation Negative Regulation Of Activin Receptor Signaling Pathway Somatic Stem Cell Maintenance Regulation Of Apoptotic Process Camera-type Eye Development Positive Regulation Of DNA Binding Nose Morphogenesis Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Fibroblast Proliferation Camera-type Eye Morphogenesis Skeletal Muscle Fiber Development Cell Motility Palate Development Retina Development In Camera-type Eye Face Morphogenesis Bone Morphogenesis SMAD Protein Signal Transduction Protein Homotrimerization
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity TGFBR1 LBD Mutants in Cancer Signaling by BMP Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Loss of Function of TGFBR1 in Cancer Generic Transcription Pathway Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-protein Interactions		20 interactors: AKT1 GLI2 GLI3 HIPK2 JUN MECP2 MYB NCOR1 NFIX PML SIN3A SKIL SMAD1 SMAD2 SMAD3 SMAD4 SNW1 SPI1 TGFBR1 TRIM28
Entrez ID		6497
HPRD ID		01271
Ensembl ID		ENSG00000157933
Uniprot IDs		P12755
PDB IDs		1MR1 1SBX
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cell Differentiation Negative Regulation Of Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transcription, DNA-templated Organ Development RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway System Development Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Multicellular Organismal Development Regulation Of Gene Expression Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process In Utero Embryonic Development Cellular Response To Growth Factor Stimulus Developmental Process Response To Growth Factor Cellular Response To Organic Substance Embryo Development Positive Regulation Of Cell Differentiation Regulation Of Cell Differentiation Response To Organic Substance Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Biosynthetic Process Tissue Development Cellular Nitrogen Compound Metabolic Process
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