SHMT2

Gene Name		serine hydroxymethyltransferase 2 (mitochondrial)
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Microtubule Cytoskeleton Mitochondrial Nucleoid Extracellular Vesicular Exosome
	Molecular Function	Chromatin Binding Glycine Hydroxymethyltransferase Activity L-allo-threonine Aldolase Activity Amino Acid Binding Pyridoxal Phosphate Binding Identical Protein Binding
	Biological Process	L-serine Biosynthetic Process One-carbon Metabolic Process Positive Regulation Of Cell Proliferation Glycine Biosynthetic Process From Serine Tetrahydrofolate Interconversion Protein Homotetramerization
Pathways
Drugs		Pyridoxal Phosphate Tetrahydrofolic acid Glycine
Diseases
GWAS
Protein-protein Interactions		6 interactors: APP ARL6IP1 CMTM5 CSNK2B NDRG1 PPARD
Entrez ID		6472
HPRD ID		00717
Ensembl ID		ENSG00000182199
Uniprot IDs		B4DJQ3 P34897 Q5BJF5 Q5HYG8
PDB IDs		3OU5
Enriched GO Terms of Interacting Partners?		Locomotion Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Chemotaxis Cellular Response To Oxygen Levels Cholesterol Metabolic Process Sterol Metabolic Process Response To External Stimulus Synaptic Growth At Neuromuscular Junction Hormone-mediated Signaling Pathway Axon Ensheathment Collateral Sprouting In Absence Of Injury Negative Regulation Of Cell Migration Intracellular Receptor Signaling Pathway Nervous System Development Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Cell Motility Positive Regulation Of Cell Cycle Process Negative Regulation Of Cellular Component Movement Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Locomotion Keratinocyte Migration Positive Regulation Of Spindle Checkpoint Axon Choice Point Recognition Steroid Metabolic Process Regulation Of Binding Response To Abiotic Stimulus Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Collagen Biosynthetic Process Adiponectin-activated Signaling Pathway Vitamin A Metabolic Process Positive Regulation Of Cell Cycle Response To Hypoxia Neuron Remodeling Negative Regulation Of Multicellular Organismal Metabolic Process Positive Regulation Of Cell Cycle Checkpoint Endothelial Tube Morphogenesis Alcohol Metabolic Process Keratinocyte Proliferation MRNA Transcription Axon Guidance Negative Regulation Of Smooth Muscle Cell Migration Movement Of Cell Or Subcellular Component Cellular Copper Ion Homeostasis Peripheral Nervous System Myelin Maintenance Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Differentiation Cell Differentiation Regulation Of Activin Receptor Signaling Pathway
Tagcloud ?		anticancer cancerogenesis capacities carbons controlling depend directs fuels glycine hot hydroxymethyltransferase importantly isoform metabolism novo nucleotides overexpressed player precursors reprogramming serine shift shmt1 starvation thymidilate towards uracil widespread