PTGS2

Gene Name		prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Caveola Neuron Projection Protein Complex
	Molecular Function	Peroxidase Activity Prostaglandin-endoperoxide Synthase Activity Lipid Binding Enzyme Binding Heme Binding Protein Homodimerization Activity Metal Ion Binding Arachidonate 15-lipoxygenase Activity
	Biological Process	Prostaglandin Biosynthetic Process Angiogenesis Prostaglandin Metabolic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Nicotinamide Metabolic Process Movement Of Cell Or Subcellular Component Inflammatory Response Response To Oxidative Stress Embryo Implantation Learning Memory Regulation Of Blood Pressure Negative Regulation Of Cell Proliferation Response To Fructose Response To Manganese Ion Response To Lithium Ion Positive Regulation Vascular Endothelial Growth Factor Production Sensory Perception Of Pain Arachidonic Acid Metabolic Process Cyclooxygenase Pathway Lipoxygenase Pathway NAD Metabolic Process Bone Mineralization Ovulation Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Fever Generation Positive Regulation Of Synaptic Plasticity Negative Regulation Of Synaptic Transmission, Dopaminergic Response To Estradiol Response To Lipopolysaccharide Response To Vitamin D Response To Tumor Necrosis Factor Cellular Response To UV Maintenance Of Blood-brain Barrier Positive Regulation Of NF-kappaB Import Into Nucleus Response To Drug Hair Cycle Positive Regulation Of Apoptotic Process Small Molecule Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Cell Cycle Positive Regulation Of Vasoconstriction Negative Regulation Of Smooth Muscle Contraction Positive Regulation Of Smooth Muscle Contraction Decidualization Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Inflammatory Response Brown Fat Cell Differentiation Response To Glucocorticoid Negative Regulation Of Calcium Ion Transport Positive Regulation Of Synaptic Transmission, Glutamatergic Oxidation-reduction Process Response To Fatty Acid Cellular Response To Mechanical Stimulus Cellular Response To ATP Cellular Response To Hypoxia Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Fibroblast Growth Factor Production Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Platelet-derived Growth Factor Production
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Metabolism of lipids and lipoproteins Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Arachidonic acid metabolism Defective AMN causes hereditary megaloblastic anemia 1 Nicotinamide salvaging Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Synthesis of 15-eicosatetraenoic acid derivatives Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Metabolism of water-soluble vitamins and cofactors Defective MUT causes methylmalonic aciduria mut type Defects in biotin (Btn) metabolism Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Defective TCN2 causes hereditary megaloblastic anemia Nicotinate metabolism Defects in vitamin and cofactor metabolism
Drugs		gamma-Homolinolenic acid Icosapent Aminosalicylic Acid Mesalazine Acetaminophen Indomethacin Nabumetone Ketorolac Tenoxicam Lenalidomide Celecoxib Tolmetin Rofecoxib Piroxicam Fenoprofen Valdecoxib Diclofenac Sulindac Flurbiprofen Etodolac Mefenamic acid Naproxen Sulfasalazine Phenylbutazone Meloxicam Carprofen Diflunisal Suprofen Salicyclic acid Meclofenamic acid Acetylsalicylic acid Bromfenac Oxaprozin Ketoprofen Balsalazide Thalidomide Ibuprofen Lumiracoxib Magnesium salicylate Salicylate-sodium Salsalate Trisalicylate-choline Ginseng Antrafenine Antipyrine Tiaprofenic acid Etoricoxib Flufenamic Acid Resveratrol Heme 1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole Prostaglandin G2 Niflumic Acid Nimesulide Lornoxicam Nepafenac Pomalidomide
Diseases
GWAS		Knee osteoarthritis ( 18471798)
Protein-protein Interactions		11 interactors: ABHD16A CASK CAV1 CELF2 COPS5 COPS7A CTNNB1 ELAVL1 NUCB1 PTGIS TP53
Entrez ID		5743
HPRD ID		02599
Ensembl ID		ENSG00000073756
Uniprot IDs		P35354
PDB IDs		1V0X
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Reactive Oxygen Species Metabolic Process Cullin Deneddylation Protein Deneddylation Cellular Response To Oxygen Levels Negative Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Calcium Ion Import Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Calcium Ion Transport Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Ischemia Positive Regulation Of Cell Death Negative Regulation Of Cell Proliferation Regulation Of Neuroblast Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Epithelial Cell Proliferation Response To Hypoxia Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Lactation Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway T Cell Differentiation In Thymus Regulation Of Reactive Oxygen Species Biosynthetic Process Apoptotic Signaling Pathway Positive Regulation Of Histone Modification Regulation Of Membrane Repolarization During Action Potential Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Ion Transmembrane Transport Cell Death Protein Oligomerization Death Canonical Wnt Signaling Pathway Positive Regulation Of Calcium Ion Transport Vasculogenesis Response To Abiotic Stimulus Regulation Of Fibroblast Proliferation Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Macromitophagy Negative Regulation Of Mitotic Cell Cycle, Embryonic
Tagcloud ?		20b 34a 7e actively ccnd ccne1 compromised dysregulated enterotoxin exacerbation foxo3 infiltrating let lungs mir mirna orchestrating participating pertaining poisoning runx1 saw seb silico smad3 staphyloccocal stringent tbx21 tgfb