EDEM2

Gene Name		ER degradation enhancer, mannosidase alpha-like 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane
	Molecular Function	Mannosyl-oligosaccharide 1,2-alpha-mannosidase Activity Calcium Ion Binding
	Biological Process	Protein Folding Response To Unfolded Protein Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 N-glycan trimming in the ER and Calnexin/Calreticulin cycle Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) ER Quality Control Compartment (ERQC) Diseases associated with N-glycosylation of proteins Calnexin/calreticulin cycle
Drugs
Diseases
GWAS		Hemostatic factors and hematological phenotypes ( 22443383) Protein C levels ( 20802025) Prothrombin time ( 22703881)
Protein-protein Interactions		1 interactors: RPS3A
Entrez ID		55741
HPRD ID		09841
Ensembl ID		ENSG00000088298
Uniprot IDs		Q9BV94
PDB IDs
Enriched GO Terms of Interacting Partners?		Cytoplasmic Translation Viral Transcription Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Protein Localization To Endoplasmic Reticulum Translational Termination Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Protein Targeting To Membrane Translational Elongation RNA Catabolic Process Cellular Protein Complex Disassembly Viral Life Cycle Protein Complex Disassembly Establishment Of Protein Localization To Membrane Translational Initiation
Tagcloud ?		catalyzes check controversy destruction edem1 edem3 edems elusive evolving glycoproteins gperad homologue homologues htm1 lectins lesser limiting man7glcnac2 man8glcnac2 man9glcnac2 mannose mannosidase mannosidases misfolded nuclease oligosaccharide possess surprisingly trimming