PPM1B

Gene Name		protein phosphatase, Mg2+/Mn2+ dependent, 1B
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Gene Ontology Annotations	Cellular Component	Cytosol Membrane
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Phosphatase Activity Protein Binding Manganese Ion Binding
	Biological Process	Protein Dephosphorylation N-terminal Protein Myristoylation Cytokine-mediated Signaling Pathway Negative Regulation Of Interferon-beta Production Peptidyl-threonine Dephosphorylation Negative Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Defense Response To Virus
Pathways		ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes
Drugs
Diseases
GWAS		Height ( 23563607)
Protein-protein Interactions		9 interactors: CDK2 CDK6 ECHS1 IKBKB IKBKG MAP3K7 MSN PPARG VAV2
Entrez ID		5495
HPRD ID		04796
Ensembl ID		ENSG00000138032
Uniprot IDs		O75688
PDB IDs		2P8E
Enriched GO Terms of Interacting Partners?		Regulation Of Immune System Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Fc-epsilon Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Metabolic Process Immune System Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Fc Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Innate Immune Response Positive Regulation Of Gene Expression Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity I-kappaB Phosphorylation Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Innate Immune Response Regulation Of Gene Expression Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Activation Of NF-kappaB-inducing Kinase Activity Immune Response Positive Regulation Of Immune Response Defense Response Positive Regulation Of NIK/NF-kappaB Signaling B Cell Homeostasis Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Apoptotic Process NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling
Tagcloud ?		2c aging arrest attenuating cellular depletion evidenced importantly imr inactivating induces involvement mapk member negatively organismal p38 partially phosphatase possibly program progressively regulating regulator replicative rescued robust senescence thereby