CPSF3

Gene Name		cleavage and polyadenylation specific factor 3, 73kDa
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Gene Ontology Annotations	Cellular Component	Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex Ribonucleoprotein Complex
	Molecular Function	RNA Binding Endoribonuclease Activity Protein Binding 5'-3' Exonuclease Activity Metal Ion Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Polyadenylation MRNA Cleavage Histone MRNA 3'-end Processing MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing Transport of Mature mRNA Derived from an Intronless Transcript RNA Polymerase II Transcription Transport of Mature mRNAs Derived from Intronless Transcripts Cleavage of Growing Transcript in the Termination Region mRNA Splicing - Major Pathway mRNA 3'-end processing Processing of Intronless Pre-mRNAs Processing of Capped Intronless Pre-mRNA Transport of Mature Transcript to Cytoplasm RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS
Protein-protein Interactions		4 interactors: CLP1 PAPOLA POLR2A YWHAG
Entrez ID		51692
HPRD ID		05825
Ensembl ID		ENSG00000119203
Uniprot IDs		G5E9W3 Q9UKF6
PDB IDs		2I7T 2I7V
Enriched GO Terms of Interacting Partners?		MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Polyadenylation RNA Splicing Termination Of RNA Polymerase II Transcription MRNA Processing MRNA Metabolic Process RNA Processing DNA-templated Transcription, Termination MRNA 3'-end Processing RNA 3'-end Processing Transcription From RNA Polymerase II Promoter Negative Regulation Of Protein Serine/threonine Kinase Activity SiRNA Loading Onto RISC Involved In RNA Interference Transcription, RNA-templated Carbohydrate Mediated Signaling Targeting Of MRNA For Destruction Involved In RNA Interference Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Negative Regulation Of Transferase Activity Negative Regulation Of Protein Phosphorylation Negative Regulation Of Phosphorylation NcRNA Metabolic Process RNA Interference Phagocytosis, Recognition MRNA Cleavage TRNA Splicing, Via Endonucleolytic Cleavage And Ligation Transcription, DNA-templated Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway RNA Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity MRNA Polyadenylation 7-methylguanosine MRNA Capping PiRNA Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of RNA Splicing 7-methylguanosine RNA Capping Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Posttranscriptional Gene Silencing Negative Regulation Of Cellular Protein Metabolic Process Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Viral Transcription Negative Regulation Of Protein Metabolic Process RNA Metabolic Process Positive Regulation Of Mitochondrion Organization Transcription Elongation From RNA Polymerase II Promoter Gene Silencing By RNA
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