PLCE1

Gene Name		phospholipase C, epsilon 1
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Receptor Signaling Protein Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Ras GTPase Binding Enzyme Binding
	Biological Process	Activation Of MAPK Activity Regulation Of Cell Growth Phospholipid Metabolic Process Diacylglycerol Biosynthetic Process Regulation Of Smooth Muscle Contraction Cytoskeleton Organization Epidermal Growth Factor Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Ras Protein Signal Transduction Heart Development Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Cell Proliferation Lipid Catabolic Process Calcium-mediated Signaling Glomerulus Development Positive Regulation Of GTPase Activity Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Ras Protein Signal Transduction Inositol Phosphate-mediated Signaling
Pathways		Synthesis of IP3 and IP4 in the cytosol Inositol phosphate metabolism
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 21685187) Dengue shock syndrome ( 22001756) Diastolic blood pressure ( 21909115) Esophageal cancer ( 21642993) Esophageal cancer and gastric cancer ( 20729852) Hypertension ( 21909115) Personality dimensions ( 21368711) Sudden cardiac arrest ( 21658281) Systolic blood pressure ( 21909115)
Protein-protein Interactions		3 interactors: HRAS KIT NRAS
Entrez ID		51196
HPRD ID		07087
Ensembl ID		ENSG00000138193
Uniprot IDs		B7ZM61 Q9P212
PDB IDs		2BYE 2BYF 2C5L
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Visual Learning Visual Behavior Associative Learning Positive Regulation Of Rac Protein Signal Transduction Learning Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Synaptic Plasticity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Learning Or Memory Fc Receptor Signaling Pathway Activation Of Protein Kinase Activity Signal Transduction By Phosphorylation Cognition Regulation Of Synaptic Transmission Response To Light Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of MAPK Cascade Regulation Of Rac Protein Signal Transduction Response To Radiation Single-organism Behavior Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Epithelial Tube Branching Involved In Lung Morphogenesis Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus Positive Regulation Of Ras Protein Signal Transduction Behavior Chemotaxis Response To Growth Factor Actin Cytoskeleton Organization Regulation Of MAPK Cascade Positive Regulation Of Small GTPase Mediated Signal Transduction Actin Filament-based Process Activation Of MAPKK Activity Lung Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Tube Development Positive Regulation Of Protein Phosphorylation
Tagcloud ?		accepted adjusting allergic ca2 certain complicated conversion differentiate digestive dual encoded epsilon gtp guanylic isoenzyme make nephrotic overview phospholipase pkc played promotes questions ras rhinitis superfamily th2 transduction upstream