ARHGEF4

Gene Name		Rho guanine nucleotide exchange factor (GEF) 4
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Gene Ontology Annotations	Cellular Component	Cytosol Ruffle Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Domain Specific Binding Rac Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Small GTPase Mediated Signal Transduction Lamellipodium Assembly Positive Regulation Of Rac GTPase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Filopodium Assembly Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS
Protein-protein Interactions		5 interactors: APC HLA-B KHDRBS1 RAC1 RHOA
Entrez ID		50649
HPRD ID		05559
Ensembl ID		ENSG00000136002
Uniprot IDs		Q9NR80 Q9NTG0
PDB IDs		2DX1 2PZ1 3NMX 3NMZ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cytoskeleton Organization Cell-cell Junction Organization Positive Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Signal Transduction Positive Regulation Of Actin Filament Bundle Assembly Cell Surface Receptor Signaling Pathway Positive Regulation Of Organelle Organization Regulation Of Stress Fiber Assembly Regulation Of Cell Projection Organization Regulation Of Cytoskeleton Organization Regulation Of Cell Differentiation Apical Junction Assembly Viral Process Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Migration Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Motility Cytokinesis Neuron Projection Morphogenesis Positive Regulation Of Nucleocytoplasmic Transport Mitotic Cell Cycle Process Regulation Of Locomotion Cell Activation Regulation Of Cellular Component Movement Regulation Of Cell Projection Assembly Positive Regulation Of Protein Polymerization Cell-cell Junction Assembly Cell Morphogenesis Involved In Differentiation Positive Regulation Of Cell Division Mitotic Cell Cycle Cell Cycle Arrest Neuron Projection Development Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Positive Regulation Of RNA Export From Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Cell Migration Cell Projection Morphogenesis Positive Regulation Of Cell Differentiation Cell Part Morphogenesis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Complex Assembly Cell Motility Regulation Of Organelle Organization Signal Transduction
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