IRF5

Gene Name		interferon regulatory factor 5
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol
	Molecular Function	Regulatory Region DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Transcription, DNA-templated Cytokine-mediated Signaling Pathway Response To Peptidoglycan Response To Muramyl Dipeptide Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Primary biliary cirrhosis ( 21399635 20639880) Rheumatoid arthritis ( 20453842) Systemic lupus erythematosus ( 18204446 23273568 23053960 18204098 21408207 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 21750679 20383147 21779181) Ulcerative colitis ( 23128233 21297633)
Protein-protein Interactions		15 interactors: ALPI CREBBP EP300 HDAC1 IKBKE IRF3 MAVS MYD88 NCOR2 SGTA SIN3A TBK1 TRAF6 TRIM15 XPO1
Entrez ID		3663
HPRD ID		06240
Ensembl ID		ENSG00000128604
Uniprot IDs		Q13568
PDB IDs		3DSH
Enriched GO Terms of Interacting Partners?		Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Activation Of Innate Immune Response Regulation Of Cytokine Production Positive Regulation Of Innate Immune Response Positive Regulation Of Cytokine Production Regulation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Innate Immune Response Viral Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor 4 Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Type I Interferon Production Regulation Of Transcription From RNA Polymerase II Promoter Immune Response Negative Regulation Of Gene Expression Defense Response Positive Regulation Of Immune System Process Type I Interferon Production Regulation Of Signal Transduction Positive Regulation Of Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway Immune System Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Interferon-alpha Production Regulation Of Defense Response To Virus Regulation Of Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Transcription, DNA-templated Positive Regulation Of Interferon-beta Production Regulation Of Immune System Process Regulation Of Nucleic Acid-templated Transcription Cellular Response To Organic Substance Regulation Of RNA Biosynthetic Process Regulation Of Immune Response Negative Regulation Of Biosynthetic Process Response To Stress Regulation Of Cytokine Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Defense Response To Virus By Host
Tagcloud ?		ablation bowel ciap colitis cytokine deregulated e3 exacerbates facilitates fate greatly immunity innate ligase limits macrophages mediate proinflammatory proteasome rel signalling tlr tlrs toll traf2 traf3 tumour unexpected upstream