IRF8

Gene Name		interferon regulatory factor 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol
	Molecular Function	Regulatory Region DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Phagocytosis Immune Response Cytokine-mediated Signaling Pathway Myeloid Cell Differentiation Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-12 Production Defense Response To Bacterium Defense Response To Protozoan Negative Regulation Of Growth Of Symbiont In Host Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Lipopolysaccharide
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Chronic lymphocytic leukemia ( 21131588 20062064) Diabetic retinopathy ( 21441570) Inflammatory bowel disease ( 23128233) Monocyte count ( 23314186) Multiple sclerosis ( 19525953 21833088) Rheumatoid arthritis ( 22446963) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 21779181) Ulcerative colitis ( 23511034)
Protein-protein Interactions		12 interactors: COPS2 IRF1 IRF2 IRF6 NFKB1 RELA SMURF2 SPI1 TOP1 TRAF6 TRIM21 ZBTB17
Entrez ID		3394
HPRD ID		03336
Ensembl ID		ENSG00000140968
Uniprot IDs		Q02556
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Interleukin-12 Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Positive Regulation Of Interleukin-12 Biosynthetic Process Cellular Response To Cytokine Stimulus Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Response To Cytokine Regulation Of Interleukin-12 Production Cellular Response To Organic Substance Negative Regulation Of Transcription From RNA Polymerase II Promoter Innate Immune Response Cytokine-mediated Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Type I Interferon Production Negative Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Membrane Protein Intracellular Domain Proteolysis Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cytokine Biosynthetic Process RNA Biosynthetic Process Regulation Of Type I Interferon Production Response To Organic Substance Regulation Of Nitrogen Compound Metabolic Process Interferon-gamma-mediated Signaling Pathway Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cytokine Production Membrane Protein Proteolysis Cellular Response To Interferon-gamma Immune Response Positive Regulation Of Interleukin-12 Production Regulation Of Metabolic Process NIK/NF-kappaB Signaling Defense Response Response To Interferon-gamma Immune System Process RNA Metabolic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway
Tagcloud ?		allelic candidiasis cybb definition designation errors ifngr1 ifngr2 il12b il12rb1 immunological impair inborn intramacrophagic isg15 mendelian msmd mycobacteria nemo overt parasites penetrance perhaps physiologically predisposition recapitulate salmonellosis virulent weakly