DNAJB2

Gene Name		DnaJ (Hsp40) homolog, subfamily B, member 2
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Gene Ontology Annotations	Cellular Component	Proteasome Complex Nucleus Cytosol Inclusion Body
	Molecular Function	Protein Binding Hsp70 Protein Binding Polyubiquitin Binding Unfolded Protein Binding Chaperone Binding Proteasome Binding
	Biological Process	Protein Folding Response To Unfolded Protein Negative Regulation Of Cell Proliferation Negative Regulation Of Cell Growth ER-associated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Refolding Negative Regulation Of Inclusion Body Assembly Negative Regulation Of Protein Deubiquitination
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		5 interactors: FBXO25 RPS27A SMAD4 UBA52 UBQLN1
Entrez ID		3300
HPRD ID		07249
Ensembl ID		ENSG00000135924
Uniprot IDs		P25686 Q53QD7
PDB IDs		2LGW
Enriched GO Terms of Interacting Partners?		Response To Hypoxia Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Oxygen Levels Viral Protein Processing Transforming Growth Factor Beta Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Regulation Of Protein Ubiquitination Notch Receptor Processing DNA-templated Transcription, Initiation Virion Assembly Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Glycogen Biosynthetic Process Intracellular Transport Of Virus Response To Abiotic Stimulus Cellular Polysaccharide Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Polysaccharide Biosynthetic Process Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of DNA-templated Transcription In Response To Stress DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Toll-like Receptor 2 Signaling Pathway Signal Transduction Involved In DNA Damage Checkpoint Toll-like Receptor 9 Signaling Pathway Signal Transduction Involved In Cell Cycle Checkpoint Glycogen Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Cell Death
Tagcloud ?		aggregation als ameliorated amyotrophic chaperone chaperones collectively dismutase familial fatal g93a hereditary hhsj1a hsj1 hsj1a immunoreactivity improvements manipulation misfolding motor neuron neuropathy neuroprotective preferentially sod1 superoxide ubiquitin ubiquitylation uim