SYNE2

Gene Name		spectrin repeat containing, nuclear envelope 2
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Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Cytoplasm Mitochondrion Focal Adhesion Integral Component Of Membrane Aggresome Sarcoplasmic Reticulum Z Disc Lamellipodium Membrane Filopodium Membrane Nuclear Membrane Nuclear Lumen Sarcoplasmic Reticulum Membrane LINC Complex Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Protein Binding Actin Filament Binding
	Biological Process	Nuclear Envelope Organization Nuclear Migration Establishment Or Maintenance Of Cell Polarity Fibroblast Migration Positive Regulation Of Cell Migration Nuclear Migration Along Microfilament Protein Localization To Nucleus Centrosome Localization Cytoskeletal Anchoring At Nuclear Membrane
Pathways		Meiotic synapsis
Drugs
Diseases
GWAS		Atrial fibrillation ( 22544366) Pulmonary function decline ( 22424883)
Protein-protein Interactions		7 interactors: ACTC1 BRAP CALM1 MAPK3 MAPK8IP2 PML UBC
Entrez ID		23224
HPRD ID		09763
Ensembl ID		ENSG00000054654
Uniprot IDs		Q6MZP0 Q8WXH0
PDB IDs		4DXS 4FI9
Enriched GO Terms of Interacting Partners?		MAPK Cascade Signal Transduction By Phosphorylation Intracellular Signal Transduction Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Epidermal Growth Factor Receptor Signaling Pathway Defense Response Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Phosphorus Metabolic Process Response To Fibroblast Growth Factor Phosphate-containing Compound Metabolic Process Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Signaling Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Kinase Activity Innate Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Cell Cycle Response To Stress Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Apoptotic Process Toll-like Receptor 5 Signaling Pathway Programmed Cell Death Toll-like Receptor 10 Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Cell Death
Tagcloud ?		ago1 argonaute cassette chip clusters constitutive crossing deep elongation enhancer enhancers exon explaining implication inclusion intergenic intragenic intronic microrna overlapping paradoxically prominent rather rnai rnas seq sirnas splicing unexpectedly