FGF4

Gene Name		fibroblast growth factor 4
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Cytosol
	Molecular Function	Fibroblast Growth Factor Receptor Binding Growth Factor Activity Heparin Binding
	Biological Process	Cartilage Condensation Positive Regulation Of Protein Phosphorylation Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Mesenchymal Cell Proliferation Stem Cell Maintenance Embryonic Hindlimb Morphogenesis Fc-epsilon Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Cell Division Cranial Suture Morphogenesis Apoptotic Process Involved In Morphogenesis Chondroblast Differentiation Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Pathways		Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease SHC-mediated cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Signaling by FGFR2 mutants DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade Signaling by activated point mutants of FGFR1 Signaling by FGFR1 mutants PI3K Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer Activated point mutants of FGFR2 PI3K events in ERBB4 signaling Signaling by ERBB2 FGFR4 ligand binding and activation Signaling by EGFR Signaling by FGFR3 mutants Downstream signal transduction Signaling by activated point mutants of FGFR3 Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Downstream signaling of activated FGFR FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation FGFR ligand binding and activation Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane FGFR3 ligand binding and activation Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR FGFR2 ligand binding and activation FRS2-mediated cascade IRS-mediated signalling FGFR1 ligand binding and activation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade
Drugs		Pentosan Polysulfate
Diseases
GWAS		Breast cancer ( 20453838)
Protein-protein Interactions		5 interactors: FGFR1 FGFR2 FGFR3 FGFR4 NRP1
Entrez ID		2249
HPRD ID		01294
Ensembl ID		ENSG00000075388
Uniprot IDs		B7U994 P08620
PDB IDs		1IJT
Enriched GO Terms of Interacting Partners?		Peptidyl-tyrosine Phosphorylation Cell Fate Commitment Positive Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Phosphatidylinositol-mediated Signaling Cellular Response To Growth Factor Stimulus Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Response To Growth Factor Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Branching Involved In Salivary Gland Morphogenesis Inner Ear Development Regulation Of ERK1 And ERK2 Cascade Tube Development Protein Autophosphorylation Alveolar Secondary Septum Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Ear Development Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation Salivary Gland Morphogenesis Lung Development Respiratory Tube Development Positive Regulation Of Phosphorylation Salivary Gland Development Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Cell-cell Signaling Lung Alveolus Development Ventricular Zone Neuroblast Division Peptidyl-amino Acid Modification Respiratory System Development Regulation Of Developmental Growth Response To Insulin Exocrine System Development Stem Cell Differentiation Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Orbitofrontal Cortex Development Epithelium Development Immune Response-regulating Cell Surface Receptor Signaling Pathway
Tagcloud ?		11q13 4nqo 7f4 amplicon amplification amplified cavity ccnd1 chr distal example fgf3 heterozygosity hras1 inbred inconsistently involving loh murine neck nitroquinoline portion predispose scc strikingly syntenic telomeric thirds twofold