F3

Gene Name		coagulation factor III (thromboplastin, tissue factor)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Cell Surface Integral Component Of Membrane Extracellular Matrix Intrinsic Component Of External Side Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Cytokine Receptor Activity Protein Binding Phospholipid Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Activation Of Plasma Proteins Involved In Acute Inflammatory Response Activation Of Blood Coagulation Via Clotting Cascade Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Blood Coagulation Blood Coagulation, Extrinsic Pathway Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Positive Chemotaxis Positive Regulation Of Protein Kinase B Signaling
Pathways		Extrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)
Drugs		Coagulation factor VIIa 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE [2\'-HYDROXY-3\'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA {5-(5-AMINO-1H-PYRROLO[3,2-B]PYRIDIN-2-YL)-6-HYDROXY-3\'-NITRO-BIPHENYL-3-YL]-ACETIC ACID
Diseases
GWAS		D-dimer levels ( 21502573) End-stage coagulation ( 23381943) Type 2 diabetes ( 22238593)
Protein-protein Interactions		5 interactors: F10 F7 FANCB FLNA PLG
Entrez ID		2152
HPRD ID		00603
Ensembl ID		ENSG00000117525
Uniprot IDs		P13726
PDB IDs		1AHW 1BOY 1DAN 1FAK 1J9C 1JPS 1NL8 1O5D 1TFH 1UJ3 1W0Y 1W2K 1WQV 1WSS 1WTG 1WUN 1WV7 1Z6J 2A2Q 2AEI 2AER 2B7D 2B8O 2C4F 2CEF 2CEH 2CEZ 2CFJ 2EC9 2F9B 2FIR 2FLB 2FLR 2HFT 2PUQ 2ZP0 2ZWL 2ZZU 3ELA 3TH2 3TH3 3TH4
Enriched GO Terms of Interacting Partners?		Blood Coagulation, Extrinsic Pathway Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Peptidyl-glutamic Acid Carboxylation Response To Wounding Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Positive Regulation Of Wound Healing Response To Stress Platelet Degranulation Positive Regulation Of Protein Kinase B Signaling Regulation Of Blood Coagulation Regulation Of Protein Kinase B Signaling Regulation Of Wound Healing Positive Regulation Of Intracellular Signal Transduction Protein Activation Cascade Response To Vitamin K Mononuclear Cell Migration Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Platelet Activation Post-translational Protein Modification Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Fibrinolysis Positive Regulation Of Signal Transduction Positive Regulation Of Cell Migration Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Positive Regulation Of Cell Motility Exocytosis Positive Regulation Of Cellular Component Movement Negative Regulation Of Fibrinolysis Positive Regulation Of Locomotion Proteolysis MRNA Transcription From RNA Polymerase II Promoter Regulation Of Fibrinolysis MRNA Transcription Blood Coagulation, Intrinsic Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Protein Localization To Cell Surface Mitotic Spindle Assembly Early Endosome To Late Endosome Transport Trophoblast Giant Cell Differentiation Secretion By Cell Actin Crosslink Formation Response To Stimulus Cytoplasmic Sequestering Of Protein Labyrinthine Layer Blood Vessel Development Muscle Cell Cellular Homeostasis
Tagcloud ?		ag ba construct csf defective efficiently equivalence g gcsfr granulocyte granulopoiesis kinetics neutropenia nonsaturating r retain saturating scn stat1 stat3 stat5 transactivation transfectants triangle truncated tyrosines up715 y704 y744