DAD1

Gene Name		defender against cell death 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Oligosaccharyl Transferase Activity Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity
	Biological Process	Blastocyst Development Protein Glycosylation Apoptotic Process Response To Nutrient Protein N-linked Glycosylation Via Asparagine Response To Drug Negative Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective MOGS causes MOGS-CDG (CDG-2b) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Defective ALG11 causes ALG11-CDG (CDG-1p)
Drugs
Diseases
GWAS
Protein-protein Interactions		1 interactors: MCL1
Entrez ID		1603
HPRD ID		02589
Ensembl ID		ENSG00000129562
Uniprot IDs		P61803 Q53G02
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Oxidative Stress-induced Cell Death Negative Regulation Of Anoikis Regulation Of Anoikis Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Response To Oxidative Stress Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell Fate Determination Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Protein Transmembrane Transport Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Neuron Apoptotic Process Apoptotic Mitochondrial Changes Positive Regulation Of Neuron Death Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Neuron Death Cell Fate Commitment Apoptotic Signaling Pathway Mitochondrion Organization Negative Regulation Of Intracellular Signal Transduction
Tagcloud ?		11q 18q21 18q22 3p aplp1 carcinoids casp1 casp4 casp5 chromosomes clustered gains gpr112 hierarchical il12a ileal mir133a or51e1 paid prkca profiling q21 q22 q23 ret runx1 rybp spock1 vmat1